Question 1

The world's first synthetic organism is known as Syntheticum venterii.

Accepted Answer

A) True 
 B)False

Question 2

Which of these would be most useful in building a genetically encoded toggle switch?

Accepted Answer

A)  two genes encoding transcription factors 
B)  two genes encoding repressors 
C)  one gene encoding a repressor,and one gene encoding a protease 
D)  three genes encoding proteases 
E)  three genes encoding transcription factors 
A)  two genes encoding transcription factors 
B)  two genes encoding repressors 
C)  one gene encoding a repressor,and one gene encoding a protease 
D)  three genes encoding proteases 
E)  three genes encoding transcription factors

Question 3

The stimulus-response graph shown is characteristic of

Accepted Answer

A)  hysteresis. 
B)  feed forward motifs. 
C)  random switching. 
D)  saturation. 
E)  futile cycling. 
A)  hysteresis. 
B)  feed forward motifs. 
C)  random switching. 
D)  saturation. 
E)  futile cycling.

Question 4

The synthetic killer microbes that have been created to treat Pseudomonas aeruginosa infections

Accepted Answer

A)  respond to the quorum-sensing molecules produced by P.aeruginosa. 
B)  encode bacteriophage that lyse the pathogenic bacteria. 
C)  constitutively produce a compound that is toxic to P.aeruginosa. 
D)  secrete an antibiotic through membrane transporters. 
E)  have been engineered to produce a stronger toxin than is naturally produced. 
A)  respond to the quorum-sensing molecules produced by P.aeruginosa. 
B)  encode bacteriophage that lyse the pathogenic bacteria. 
C)  constitutively produce a compound that is toxic to P.aeruginosa. 
D)  secrete an antibiotic through membrane transporters. 
E)  have been engineered to produce a stronger toxin than is naturally produced.

Question 5

What type of logic gate is represented by this table? $$\begin{array} { | l | l | l | } 
\hline \text { Input A } & \text { Input B } & \text { Output } \
\hline 0 & 0 & 0 \
\hline 0 & 1 & 1 \
\hline 1 & 0 & 1 \
\hline 1 & 1 & 1 \
\hline
\end{array}$$

Accepted Answer

A)  NOT 
B)  NAND 
C)  XOR 
D)  OR 
E)  AND 
A)  NOT 
B)  NAND 
C)  XOR 
D)  OR 
E)  AND

Question 6

Dozens of biomarkers have been identified that can predict risk of metastasis in breast cancer.

Accepted Answer

A) True 
 B)False

Question 7

Which of the following is not a characteristic of synthetic biology?

Accepted Answer

A)  well-defined parts 
B)  modularity 
C)  ethics 
D)  reusable parts 
E)  random mutagenesis by chemicals 
A)  well-defined parts 
B)  modularity 
C)  ethics 
D)  reusable parts 
E)  random mutagenesis by chemicals

Question 8

mRNA abundance can be accounted for almost entirely by considering mRNA production rates and degradation rates.

Accepted Answer

A) True 
 B)False

Question 9

The steady state level of mRNA is

Accepted Answer

A)  invariant across transcripts within a species. 
B)  invariant across transcripts within a cell type. 
C)  production rate divided by degradation rate. 
D)  emergent and cannot be predicted. 
E)  independent of the rate of transcription. 
A)  invariant across transcripts within a species. 
B)  invariant across transcripts within a cell type. 
C)  production rate divided by degradation rate. 
D)  emergent and cannot be predicted. 
E)  independent of the rate of transcription.

Question 10

In Mycobacterium tuberculosis,the ethA gene product confers

Accepted Answer

A)  resistance to phage therapy. 
B)  the ability to colonize a host. 
C)  antibiotic resistance. 
D)  rapid growth. 
E)  sensitivity to ethionamide. 
A)  resistance to phage therapy. 
B)  the ability to colonize a host. 
C)  antibiotic resistance. 
D)  rapid growth. 
E)  sensitivity to ethionamide.

Question 11

Synthetic biology is best described as the combination of molecular biology with principles of synthetic chemistry.

Accepted Answer

A) True 
 B)False

Question 12

Artemisinin is a natural compound that is an important antimalarial drug.

Accepted Answer

A) True 
 B)False

Question 13

The watermarks in a synthetic genome could be used to distinguish it from a natural genome.

Accepted Answer

A) True 
 B)False

Question 14

The first successfully transplanted genome was assembled from synthetic ssDNA oligonucleotides.

Accepted Answer

A) True 
 B)False

Question 15

What is represented in the stimulus-response graph shown?

Accepted Answer

A)  hysteresis 
B)  bistability 
C)  feed back 
D)  instability 
E)  incomplete data 
A)  hysteresis 
B)  bistability 
C)  feed back 
D)  instability 
E)  incomplete data

Question 16

The leader of the team that created the first synthetic genome also led one of the two major human genome sequence projects.

Accepted Answer

A) True 
 B)False

Question 17

Which system is most likely to produce the stimulus-response curve shown here?  
In the systems shown below,the concentration of molecule 3 represents the stimulus,and the concentration of molecule 2 is the response.Molecule 1 is a substrate of molecule 3.Molecule 4 is an inactive form of molecule 3.Molecule 2 activates molecule 5.

Accepted Answer

A) 
  
B) 
  
C) 
  
D) 
  
E) 
  
A) 
  
B) 
  
C) 
  
D) 
  
E)

Question 18

A toggle switch is a necessary component of a cellular clock.

Accepted Answer

A) True 
 B)False

Question 19

Systems biology is discovery-driven,rather than hypothesis-driven.

Accepted Answer

A) True 
 B)False

Question 20

Explain the advantages of modularity in synthetic biology.

Accepted Answer

Modularity allows parts to be reused in

Exam 22: Exploring Synthetic Biology: Concepts, Techniques, and Applications

The world's first synthetic organism is known as Syntheticum venterii.

Which of these would be most useful in building a genetically encoded toggle switch?

The stimulus-response graph shown is characteristic of

The synthetic killer microbes that have been created to treat Pseudomonas aeruginosa infections

What type of logic gate is represented by this table? Input A Input B Output 0 0 0 0 1 1 1 0 1 1 1 1

Dozens of biomarkers have been identified that can predict risk of metastasis in breast cancer.

Which of the following is not a characteristic of synthetic biology?

mRNA abundance can be accounted for almost entirely by considering mRNA production rates and degradation rates.

The steady state level of mRNA is

In Mycobacterium tuberculosis,the ethA gene product confers

Synthetic biology is best described as the combination of molecular biology with principles of synthetic chemistry.

Artemisinin is a natural compound that is an important antimalarial drug.

The watermarks in a synthetic genome could be used to distinguish it from a natural genome.

The first successfully transplanted genome was assembled from synthetic ssDNA oligonucleotides.

What is represented in the stimulus-response graph shown?

The leader of the team that created the first synthetic genome also led one of the two major human genome sequence projects.

A toggle switch is a necessary component of a cellular clock.

Systems biology is discovery-driven,rather than hypothesis-driven.

Explain the advantages of modularity in synthetic biology.

Mendels Principles of Heredity

Extensions to Mendels Laws

The Chromosome Theory of Inheritance

Linkage, Recombination, and the Mapping of Genes on Chromosomes

Dna Structure, Replication, and Recombination

Anatomy and Function of a Gene: Dissection Through Mutation

Gene Expression: the Flow of Information From Dna to Rna to Protein

Digital Analysis of Genomes

Genome Annotation

Analyzing Genomic Variation

The Eukaryotic Chromosome

Chromosomal Rearrangements and Changes in Chromosome Number

Bacterial Genetics

Organellar Inheritance

Gene Regulation in Prokaryotes

Gene Regulation in Eukaryotes

Manipulating the Genomes of Eukaryotes

The Genetic Analysis of Development

The Genetics of Cancer

Variation and Selection in Populations

Genetics of Complex Traits

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