Exam 8: Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

What recognizes ubiquitinated signaling receptors and sorts them into the membranes that give rise to the internal vesicles of the late endosomes?

What can be used to distinguish RER from SER?

Which endosomes are typically located in the more interior part of the cell, near the nucleus?

Which of the differences between early and late endosomes outlined below is NOT correct?

What is the effect on a yeast cell of the presence of a mutant gene involved in vesicle fusion?

What kind of molecules prepare polypeptides for mitochondrial uptake, including those that specifically direct mitochondrial proteins to the cytosolic surface of the outer mitochondrial membrane?

Which is a limitation of using extracellular vesicles for drug delivery?

Most proteins destined for the chloroplast are synthesized with a removable ________ called the ______.

Which of the following are enzymes involved in detoxification of organic compounds in the SER of liver cells? (Select all correct choices)

What is the primary adaptor protein of the COPII coat that interacts specifically with the ER export signals in the cytosolic tails of membrane proteins that are destined to traffic on to the Golgi complex?

What would happen if the enzyme that adds phosphate groups to the appropriate mannose residues on the carbohydrate chains of lysosomal enzymes were defective?

The inner leaflet of the plasma membrane contains elevated levels of _____, which plays an important role in the recruitment of proteins involved in clathrin-mediated endocytosis, like dynamin and AP2.

Which of the following is a function associated with the smooth endoplasmic reticulum in at least some cells?

Studies of cell physiology that occur in test tubes that do not contain whole cells are called:

Blobel, Sabatini and Dobberstein proposed that the site of protein synthesis is determined by information contained in the N-terminal portion of the protein, the first part to emerge from the ribosome. What did they call their proposal?

What is responsible for recognizing lysosomal enzymes and localizing them to the lysosomes? (Select all correct choices)

The targeting sequence of a mitochondrial-matrix protein is found at the molecule's N-terminus and includes a number of positively charged residues. What is this targeting sequence called?

How many mitochondrial subcompartments exist into which proteins can be delivered?

The coat of vesicles that transport materials around the cell interior ___________.

What removes the stroma-targeting domain and where does the removal occur?