Exam 6: Consolidating Ltp: Specific Mechanisms

What is the basic signal cascade that produces local protein synthesis?

mRNA depend on _______ and motor proteins for delivery to the dendritic spine region

Blocking protein synthesis has no effect on mRNA distribution produced by glutamate release onto a spine.

Clustered spines can capture protein synthesized in their vicinity.

The "protein on demand system" offers which advantage(s)? (Select all that apply.)

The _______ methodology could be used to prevent the translation of a specific protein.

What is the critical contribution of the mTOR complex in local protein synthesis?

Proteasomes tag proteins for degradation.

According to the synaptic tag and capture hypothesis, _______. (Select all that apply.)

Polyribosomes _______ mRNA into protein

What are some advantages of LTP being induced in clusters of spines?

Briefly describe the role of microtubules.

Interfering with BDNF activating _______ receptors prevent the translation of TOP mRNAs and development of long-lasting LTP.

What is an antisense oligonucleotide? How is it used to study LTP?

The induction of LTP is accompanied by local movement of polyribosomes into the spine.

The antisense methodology allows researchers to directly prevent transcription.

Only untagged synapses can capture plasticity products produced by a strong stimulus.

All tagged synapses participate in the generation of new plasticity products.

Ubiquitin tags proteins for degradation.

According to the synaptic clustered plasticity model, synapses capture protein that is _______ in the local region