Exam 6: Consolidating Ltp: Specific Mechanisms

Which statement(s) is/are benefits of strengthening synapses in clusters? (Select all that apply.)

Stimulated spines have fewer polyribosomes than unstimulated spine.

BDNF is synthesized, stored, and released from the presynaptic neuron, but it can also be released from dendrites.

What is the general advantage of local protein synthesis?

The mTOR-TOP pathway is critical for the induction of LTP.

What are TOP mRNAs? Explain how they enhance translation capacity?

What are primary steps to the initiation of local protein synthesis?

Explain how a weak stimulation can produce L-LTP?

What is rapamycin?

The application of BDNF can produce long-lasting LTP even if the translation of Arc is prevented by antisense.

Local protein synthesis can provide protein in the right places on demand.

One advantage of clustered synapses is that it is easier for the glutamate release to depolarize the neuron.

Microtubules are an essential component of mRNA delivery to the dendritic spine region.

Local protein synthesis occurs before mRNA is delivered to the dendritic spine region.

Discuss the significance of the concept of the protein-on-demand system in relation to the classic central dogma view.

Applying antisense to Arc prevents BDNF-induced _______.

Inhibiting actin polymerization has no effect on the capture of mRNA by spines.

What is the relationship between transcription repressor proteins, the UPS system, and enduring LTP?