Question 1

Endocannabinoids contribute to retrograde signaling in the hippocampus by

Accepted Answer

A)  blocking the reuptake transporters. 
B)  blocking CB1 autoreceptors on the presynaptic terminals. 
C)  inhibiting Ca2+-mediated GABA release. 
D)  activating the CB1 receptors and increasing GABA release. 
A)  blocking the reuptake transporters. 
B)  blocking CB1 autoreceptors on the presynaptic terminals. 
C)  inhibiting Ca2+-mediated GABA release. 
D)  activating the CB1 receptors and increasing GABA release. C

Question 2

Which health effect of chronic marijuana use is least substantiated?

Accepted Answer

A)  Increased risk of bronchitis 
B)  Decreased resistance to viral infections 
C)  Reduction in reproductive function 
D)  Increased development of precancerous lung conditions 
A)  Increased risk of bronchitis 
B)  Decreased resistance to viral infections 
C)  Reduction in reproductive function 
D)  Increased development of precancerous lung conditions B

Question 3

Which statement about the endocannabinoids is false?

Accepted Answer

A)  They are synthesized by FAAH. 
B)  They include arachidonic derivatives such as 2-AG and anandamide. 
C)  They are not stored in vesicles. 
D)  They are synthesized and released when needed, probably in response to Ca2+. 
A)  They are synthesized by FAAH. 
B)  They include arachidonic derivatives such as 2-AG and anandamide. 
C)  They are not stored in vesicles. 
D)  They are synthesized and released when needed, probably in response to Ca2+. A

Question 4

Recent imaging studies have demonstrated some evidence of abnormalities or alterations in several brain structures, including the _______ and the _______.

Accepted Answer

A)  amygdala; nucleus accumbens 
B)  hippocampus; prefrontal cortex 
C)  hypothalamus; prefrontal cortex 
D)  VTA; limbic system 
A)  amygdala; nucleus accumbens 
B)  hippocampus; prefrontal cortex 
C)  hypothalamus; prefrontal cortex 
D)  VTA; limbic system

Question 5

Identify several factors that may increase an adolescent's likelihood of using marijuana in the first place, or progressing from initial to regular use.

Accepted Answer

Risk factors in the development of heavy

Question 6

To study the role of the endogenous cannabinoids, scientists have used mice genetically engineered to _______ and _______.

Accepted Answer

A)  lack these compounds; drugs that block CB1 receptors 
B)  lack CB1 and CB2 receptors; drugs that block CB1 receptors 
C)  overexpress CB1 receptors; drugs that prevent metabolism of these compounds 
D)  overexpress these compounds; drugs that enhance synthesis of these compounds 
A)  lack these compounds; drugs that block CB1 receptors 
B)  lack CB1 and CB2 receptors; drugs that block CB1 receptors 
C)  overexpress CB1 receptors; drugs that prevent metabolism of these compounds 
D)  overexpress these compounds; drugs that enhance synthesis of these compounds

Question 7

Describe the historical use of marijuana as agricultural commodity, medicine, and recreational drug in the United States. What role did Anslinger and various regulatory policies have on this use?

Accepted Answer

Hemp use may go back at least 8000 years

Question 8

Which of the following is not an adverse reaction to marijuana?

Accepted Answer

A)  Anxiety or panic, especially in first time users 
B)  Feelings of paranoia, with high doses 
C)  Nausea and gastrointestinal upset 
D)  Depression or dysphoria 
A)  Anxiety or panic, especially in first time users 
B)  Feelings of paranoia, with high doses 
C)  Nausea and gastrointestinal upset 
D)  Depression or dysphoria

Question 9

Which statement about the uses of marijuana is false?

Accepted Answer

A)  Hemp was originally grown in colonial America for its psychoactive properties. 
B)  Hemp has important non-drug purposes, and is used in rope, cloth, and paper. 
C)  Cannabis plants contain more than 60 cannabinoids, some with psychoactive properties that make the plant attractive as a drug. 
D)  Religious use of marijuana dates back to ancient China and India. 
A)  Hemp was originally grown in colonial America for its psychoactive properties. 
B)  Hemp has important non-drug purposes, and is used in rope, cloth, and paper. 
C)  Cannabis plants contain more than 60 cannabinoids, some with psychoactive properties that make the plant attractive as a drug. 
D)  Religious use of marijuana dates back to ancient China and India.

Question 10

Describe the evidence, from animal studies, that the endocannabinoids are involved in the extinction of learned fear responses.

Accepted Answer

In rats and mice, an auditory stimulus p

Question 11

What happens during precipitated withdrawal from cannabinoids in animal studies?

Accepted Answer

A)  The THC being administered is withdrawn. 
B)  The CB1 antagonist SR 141716A is administered. 
C)  The CB1 drugs WIN 55,212-2 and SR 141716A are administered at the same time to precipitate withdrawal. 
D)  THC is stopped and SR 141716A is administered. 
A)  The THC being administered is withdrawn. 
B)  The CB1 antagonist SR 141716A is administered. 
C)  The CB1 drugs WIN 55,212-2 and SR 141716A are administered at the same time to precipitate withdrawal. 
D)  THC is stopped and SR 141716A is administered.

Question 12

Moreau is sometimes referred to as the "father of psychopharmacology," mainly because he

Accepted Answer

A)  introduced hashish to high society in nineteenth-century Paris. 
B)  was responsible for founding the "club of hashish eaters." 
C)  was one of the first to study the possible relationship between hashish use and mental illness. 
D)  was a researcher who studied drugs and personally experimented with hashish. 
A)  introduced hashish to high society in nineteenth-century Paris. 
B)  was responsible for founding the "club of hashish eaters." 
C)  was one of the first to study the possible relationship between hashish use and mental illness. 
D)  was a researcher who studied drugs and personally experimented with hashish.

Question 13

Which statement regarding treatment of cannabis dependence is false?

Accepted Answer

A)  It may include outpatient programs offering cognitive behavior therapy and relapse prevention therapy. 
B)  It is much more successful than treatment of other drug dependence problems, with very little relapse. 
C)  It can include pharmacotherapy with antidepressants and mood stabilizers. 
D)  It could someday include the use of oral THC to moderate marijuana cravings. 
A)  It may include outpatient programs offering cognitive behavior therapy and relapse prevention therapy. 
B)  It is much more successful than treatment of other drug dependence problems, with very little relapse. 
C)  It can include pharmacotherapy with antidepressants and mood stabilizers. 
D)  It could someday include the use of oral THC to moderate marijuana cravings.

Question 14

Marijuana appears to stimulate dopamine release in the nucleus accumbens via inhibition of _______ release in the _______.

Accepted Answer

A)  glutamate; VTA 
B)  GABA; VTA 
C)  glutamate; substantia nigra 
D)  GABA; substantia nigra 
A)  glutamate; VTA 
B)  GABA; VTA 
C)  glutamate; substantia nigra 
D)  GABA; substantia nigra

Question 15

According to research, which factor is most likely to encourage an individual to progress from occasional to heavy marijuana use?

Accepted Answer

A)  The person is a risk-taker. 
B)  The person has nagging, over-involved parents. 
C)  The person's first experiences with marijuana were positive. 
D)  The person has too many adult responsibilities. 
A)  The person is a risk-taker. 
B)  The person has nagging, over-involved parents. 
C)  The person's first experiences with marijuana were positive. 
D)  The person has too many adult responsibilities.

Question 16

The major psychoactive ingredient of the marijuana plant is

Accepted Answer

A)  cannabinol. 
B)  $\Delta$9-tetrahydrocannabinol. 
C)  anandamide. 
D)  $\Delta$6-tetrahydrocannabinol. 
A)  cannabinol. 
B)  $\Delta$9-tetrahydrocannabinol. 
C)  anandamide. 
D)  $\Delta$6-tetrahydrocannabinol.

Question 17

Cannabinoids could be used therapeutically to treat all of the following except

Accepted Answer

A)  neuropathic pain. 
B)  mood disorders. 
C)  nausea. 
D)  obesity. 
A)  neuropathic pain. 
B)  mood disorders. 
C)  nausea. 
D)  obesity.

Question 18

Which statement regarding the most prevalent CNS cannabinoid receptor is false?

Accepted Answer

A)  It was discovered in 1988 by two independent groups of researchers. 
B)  It is an ionotropic receptor, currently designated CB1. 
C)  It plays a role in locomotor activity, coordination, and memory. 
D)  It is expressed in the basal ganglia, cerebellum, hippocampus, and cortex. 
A)  It was discovered in 1988 by two independent groups of researchers. 
B)  It is an ionotropic receptor, currently designated CB1. 
C)  It plays a role in locomotor activity, coordination, and memory. 
D)  It is expressed in the basal ganglia, cerebellum, hippocampus, and cortex.

Question 19

Which of the following is not a characteristic of amotivational syndrome?

Accepted Answer

A)  Anxiety 
B)  Lack of planning 
C)  Decreased productivity 
D)  Apathy 
A)  Anxiety 
B)  Lack of planning 
C)  Decreased productivity 
D)  Apathy

Question 20

Marijuana-induced deficits in memory can be reduced by administration of

Accepted Answer

A)  cannabidiol (CB
D) . 
B)  alcohol. 
C)  2-AG. 
D)  anandamide. 
A)  cannabidiol (CB
D) . 
B)  alcohol. 
C)  2-AG. 
D)  anandamide.

Endocannabinoids contribute to retrograde signaling in the hippocampus by

Which health effect of chronic marijuana use is least substantiated?

Which statement about the endocannabinoids is false?

Recent imaging studies have demonstrated some evidence of abnormalities or alterations in several brain structures, including the _ and the _.

Identify several factors that may increase an adolescent's likelihood of using marijuana in the first place, or progressing from initial to regular use.

To study the role of the endogenous cannabinoids, scientists have used mice genetically engineered to _ and _.

Describe the historical use of marijuana as agricultural commodity, medicine, and recreational drug in the United States. What role did Anslinger and various regulatory policies have on this use?

Which of the following is not an adverse reaction to marijuana?

Which statement about the uses of marijuana is false?

Describe the evidence, from animal studies, that the endocannabinoids are involved in the extinction of learned fear responses.

What happens during precipitated withdrawal from cannabinoids in animal studies?

Moreau is sometimes referred to as the "father of psychopharmacology," mainly because he

Which statement regarding treatment of cannabis dependence is false?

Marijuana appears to stimulate dopamine release in the nucleus accumbens via inhibition of _ release in the _.

According to research, which factor is most likely to encourage an individual to progress from occasional to heavy marijuana use?

The major psychoactive ingredient of the marijuana plant is

Cannabinoids could be used therapeutically to treat all of the following except

Which statement regarding the most prevalent CNS cannabinoid receptor is false?

Which of the following is not a characteristic of amotivational syndrome?

Marijuana-induced deficits in memory can be reduced by administration of

Principles of Pharmacology, Structure and Function of the Nervous System

Chemical Signaling by Neurotransmitters and Hormones

Methods of Research in Psychopharmacology

Catecholamines

Serotonin

Acetylcholine

Glutamate and GABA

Drug Abuse and Addiction

Alcohol

The Opioids

Psychomotor Stimulants:

Nicotine and Caffeine

Hallucinogens, PCP, and Ketamine

Inhalants, GHB, and Anabolicandrogenic Steroids

Disorders of Anxiety and Impulsivity and the Drugs Used to Treat These Disorders

Affective Disorders: Antidepressants and Mood Stabilizers

Schizophrenia: Antipsychotic Drugs

Neurodegenerative Disorders

Filters

Exam 13: Marijuana and the Cannabinoids

Endocannabinoids contribute to retrograde signaling in the hippocampus by

Which health effect of chronic marijuana use is least substantiated?

Which statement about the endocannabinoids is false?

Recent imaging studies have demonstrated some evidence of abnormalities or alterations in several brain structures, including the _______ and the _______.

Identify several factors that may increase an adolescent's likelihood of using marijuana in the first place, or progressing from initial to regular use.

To study the role of the endogenous cannabinoids, scientists have used mice genetically engineered to _______ and _______.

Describe the historical use of marijuana as agricultural commodity, medicine, and recreational drug in the United States. What role did Anslinger and various regulatory policies have on this use?

Which of the following is not an adverse reaction to marijuana?

Which statement about the uses of marijuana is false?

Describe the evidence, from animal studies, that the endocannabinoids are involved in the extinction of learned fear responses.

What happens during precipitated withdrawal from cannabinoids in animal studies?

Moreau is sometimes referred to as the "father of psychopharmacology," mainly because he

Which statement regarding treatment of cannabis dependence is false?

Marijuana appears to stimulate dopamine release in the nucleus accumbens via inhibition of _______ release in the _______.

According to research, which factor is most likely to encourage an individual to progress from occasional to heavy marijuana use?

The major psychoactive ingredient of the marijuana plant is

Cannabinoids could be used therapeutically to treat all of the following except

Which statement regarding the most prevalent CNS cannabinoid receptor is false?

Which of the following is not a characteristic of amotivational syndrome?

Marijuana-induced deficits in memory can be reduced by administration of

Principles of Pharmacology, Structure and Function of the Nervous System

Chemical Signaling by Neurotransmitters and Hormones

Methods of Research in Psychopharmacology

Catecholamines

Serotonin

Acetylcholine

Glutamate and GABA

Drug Abuse and Addiction

Alcohol

The Opioids

Psychomotor Stimulants:

Nicotine and Caffeine

Hallucinogens, PCP, and Ketamine

Inhalants, GHB, and Anabolicandrogenic Steroids

Disorders of Anxiety and Impulsivity and the Drugs Used to Treat These Disorders

Affective Disorders: Antidepressants and Mood Stabilizers

Schizophrenia: Antipsychotic Drugs

Neurodegenerative Disorders

Filters

Recent imaging studies have demonstrated some evidence of abnormalities or alterations in several brain structures, including the _ and the _.

To study the role of the endogenous cannabinoids, scientists have used mice genetically engineered to _ and _.

Marijuana appears to stimulate dopamine release in the nucleus accumbens via inhibition of _ release in the _.