Question 1

Match the antifungal agent with its mode of action.
-Binds microtubular proteins

Accepted Answer

A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole 
A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole B

Question 2

The Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi;Approved Standard (M38-A2)describes the guidelines for antifungal susceptibility testing for molds.The suspension must be standardized with a spectrophotometer.Susceptibility testing is determined by which method?

Accepted Answer

A) Disk diffusion 
B) Microdilution 
C) Broth dilution 
D) Immunodiffusion 
A) Disk diffusion 
B) Microdilution 
C) Broth dilution 
D) Immunodiffusion B

Question 3

A patient who is positive for the human immunodeficiency virus (HIV)is diagnosed with a Cryptococcus neoformans infection.The attending resident prescribed Griseofulvin;however,the patient's condition did not seem to improve.Which one of the following statements explains this discrepancy?

Accepted Answer

A) The dose should be increased to penetrate the blood-brain barrier. 
B) Nystatin,which would have been more effective,should have been prescribed. 
C) Griseofulvin is not effective against C.neoformans;therefore the therapy should be changed. 
D) Potassium iodide is the therapy of choice,not griseofulvin. 
A) The dose should be increased to penetrate the blood-brain barrier. 
B) Nystatin,which would have been more effective,should have been prescribed. 
C) Griseofulvin is not effective against C.neoformans;therefore the therapy should be changed. 
D) Potassium iodide is the therapy of choice,not griseofulvin. C

Question 4

Match the antifungal agent with its mode of action.
-Is a glucan synthesis inhibitor

Accepted Answer

A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole 
A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole

Question 5

The agency that provides documents and sets standards for antifungal susceptibility testing is the:

Accepted Answer

A) National Accrediting Agency for Clinical Library Sciences (NAACLS). 
B) Association of Specialized and Cooperative Library Agencies (ASCLS). 
C) College of American Pathologists (CAP). 
D) Clinical Laboratory Standards Institute (CLSI). 
A) National Accrediting Agency for Clinical Library Sciences (NAACLS). 
B) Association of Specialized and Cooperative Library Agencies (ASCLS). 
C) College of American Pathologists (CAP). 
D) Clinical Laboratory Standards Institute (CLSI).

Question 6

A patient is diagnosed with an invasive Aspergillosis infection.The antifungal therapy that should be administered is:

Accepted Answer

A) nystatin. 
B) griseofulvin. 
C) amphotericin B. 
D) fluconazole. 
A) nystatin. 
B) griseofulvin. 
C) amphotericin B. 
D) fluconazole.

Question 7

Match the antifungal agent with its mode of action.
-Inhibits protein synthesis

Accepted Answer

A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole 
A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole

Question 8

Match the antifungal agent with its mode of action.
-Interferes with ergosterol synthesis

Accepted Answer

A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole 
A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole

Question 9

Match the antifungal agent with its mode of action.
-Alters membrane permeability

Accepted Answer

A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole 
A) Amphotericin B 
B) Griseofulvin 
C) 5-Fluorocytosine 
D) Echinocandin 
E) Azole

Exam 62: Anti-fungal Susceptibility Testing, therapy, and Prevention

Match the antifungal agent with its mode of action. -Binds microtubular proteins

A patient who is positive for the human immunodeficiency virus (HIV)is diagnosed with a Cryptococcus neoformans infection.The attending resident prescribed Griseofulvin;however,the patient's condition did not seem to improve.Which one of the following statements explains this discrepancy?

Match the antifungal agent with its mode of action. -Is a glucan synthesis inhibitor

The agency that provides documents and sets standards for antifungal susceptibility testing is the:

A patient is diagnosed with an invasive Aspergillosis infection.The antifungal therapy that should be administered is:

Match the antifungal agent with its mode of action. -Inhibits protein synthesis

Match the antifungal agent with its mode of action. -Interferes with ergosterol synthesis

Match the antifungal agent with its mode of action. -Alters membrane permeability

Microbial Taxonomy

Bacterial Genetics, metabolism, and Structure

Host-Microorganism Interactions

Laboratory Safety

Specimen Management

Role of Microscopy

Traditional Cultivation and Identification

Nucleic Acid-Based Analytic Methods for Microbial Identification and Characterization

Overview of Immunochemical Methods Used for Organism Detection

Principles of Antimicrobial Action Resistance

Laboratory Methods and Strategies for Antimicrobial Susceptibility Testing

Staphylococcus, Micrococcus, and Similar Organisms

Streptococcus, Enterococcus, and Similar Organisms

Bacillus and Similar Organisms

Listeria Corynebacterium and Similar Organisms

Erysipelothrix, Lactobacillus, and Similar Organisms

Nocardia, Streptomyces, Rhodococcus, Oerskovia, and Similar Organisms

Enterobacteriaceae

Acinetobacter, Stenotrophomonas, and Other Organisms

Pseudomonas, Burkholderia, and Similar Organisms

Achromobacter, Rhizobium, Ochrobactrum, and Similar Organisms

Chryseobacterium, Sphingobacterium, and Similar Organisms

Alcaligenes, Bordetella Nonpertussis, Comamonas, and Similar Organisms

Vibrio, aeromonas, Plesiomonas Shigelloides, and Chromobacterium Violaceum

Sphingomonas Paucimobilis and Similar Organisms

Moraxella

Eikenella Corrodens and Similar Organisms

Pasteurella and Similar Organisms

Actinobacillus, Kingella, Cardiobacterium, Capnocytophaga, and Similar Organisms

Haemophilus

Bartonella and Afipia

Campylobacter, Arcobacter, and Helicobacter

Legionella

Brucella

Bordetella Pertussis and Bordetella Parapertussis

Francisella

Streptobacillus Moniliformis and Spirillum Minus

Neisseria and Moraxella Catarrhalis

Overview and General Considerations

Laboratory Considerations

Mycobacteria

Obligate Intracellular and Non-culturable Bacterial Agents

Cell Walldeficient Bacteria: Mycoplasma and Ureaplasma

The Spirochetes

Overview of the Methods and Strategies in Parasitology

Intestinal Protozoa

Blood and Tissue Protozoa

Protozoa From Other Body Sites

Intestinal Nematodes

Tissue Nematodes

Blood Nematodes

Intestinal Cestodes

Tissue Cestodes

Intestinal Trematodes

Liver and Lung Trematodes

Blood Trematodes

Overview of Fungal Identification Methods and Strategies

Hyaline Molds, Zygomycetes, Dermatophytes, and Opportunistic and Systemic Mycoses

Dematiaceious Molds

Opportunistic Atypical Fungus: Pjirovecii

The Yeasts

Overview of the Methods and Strategies in Virology

Viruses in Human Disease

Antiviral Therapy Susceptibility Testing and Prevention

Bloodstream Infections

Infections of the Lower Respiratory Tract

Upper Respiratory Tract Infections and Other Infections of the Oral Cavity and Neck

Meningitis and Other Infections of the Central Nervous Systems

Infections of the Eyes ears and Sinuses

Infections of the Urinary Tract

Genital Tract Infections