Question 1

A mechanism by which cancer cells can evade an immune response involves an alteration in the amount of MIC on the cell surface by

Accepted Answer

A) decreasing the level of MIC transcription 
B) cleavage of MIC at the cell surface by a protease 
C) switching from a transmembrane form of MIC to a secreted form 
D) cytosolic degradation of MIC in proteasomes 
E) alternative mRNA splicing resulting in a truncated form of MIC that is no longer able to bind to NKG2D. 
A) decreasing the level of MIC transcription 
B) cleavage of MIC at the cell surface by a protease 
C) switching from a transmembrane form of MIC to a secreted form 
D) cytosolic degradation of MIC in proteasomes 
E) alternative mRNA splicing resulting in a truncated form of MIC that is no longer able to bind to NKG2D.

Question 2

Match between columns
                        Premises: dexamethasone
lenalidomide
phosphoantigen
elotuzumab
bortezomib
ADAM33 metalloproteinase

Accepted Answer

The Answer of proteasome inhibitor and opsonizes tumor cells and is...

Question 3

A.What are the two main classes of gene that,if not expressed correctly,can lead to malignant transformation?
B.What are the gene products made by each class?

Accepted Answer

A.Proto-oncogenes and tumor suppressor g

Question 4

Which cytokines are associated with tumor-induced suppression of the immune response? (Select all that apply.)

Accepted Answer

A) IL-12 
B) IL-2 
C) TGF-β 
D) IL-4 
E) IL-10. 
A) IL-12 
B) IL-2 
C) TGF-β 
D) IL-4 
E) IL-10.

Question 5

Which of the following are true for cancer stem cells? (Select all that apply.)

Accepted Answer

A) They are self-renewing. 
B) They are highly susceptible to radiation. 
C) They are resistant to toxins used in chemotherapy. 
D) They may be present in low numbers without causing relapse. 
E) They may cause cancer if donated in organ transplants. 
A) They are self-renewing. 
B) They are highly susceptible to radiation. 
C) They are resistant to toxins used in chemotherapy. 
D) They may be present in low numbers without causing relapse. 
E) They may cause cancer if donated in organ transplants.

Question 6

When the immune system is involved in _____,an appraisal for cancer cells is occurring.

Accepted Answer

A) malignant transformation 
B) apoptosis 
C) antineoplasia 
D) immunosurveillance 
E) immunosuppression. 
A) malignant transformation 
B) apoptosis 
C) antineoplasia 
D) immunosurveillance 
E) immunosuppression.

Question 7

Explain how the immune mechanisms for the detection of cancer cells are (A)similar to and (B)different from those that detect virus-infected cells.

Accepted Answer

A.NK cells and cytotoxic T cells detect

Question 8

Burkitt's lymphoma is a tumor associated with _____ infection,which causes _____ to divide uncontrollably.

Accepted Answer

A) Epstein-Barr virus; B cells 
B) hepatitis B virus; epithelial 
C) human T-cell leukemia; hepatocytes 
D) human herpesvirus; T cells 
E) papillomavirus; uterine cells. 
A) Epstein-Barr virus; B cells 
B) hepatitis B virus; epithelial 
C) human T-cell leukemia; hepatocytes 
D) human herpesvirus; T cells 
E) papillomavirus; uterine cells.

Question 9

DNA viruses associated with cancer development include _____.(Select all that apply.)

Accepted Answer

A) human papillomavirus (HPV) 
B) human immunodeficiency virus (HIV-1) 
C) human herpesvirus 8 (HHV8) 
D) Epstein-Barr virus (EBV) 
E) malignant transformation. 
A) human papillomavirus (HPV) 
B) human immunodeficiency virus (HIV-1) 
C) human herpesvirus 8 (HHV8) 
D) Epstein-Barr virus (EBV) 
E) malignant transformation.

Question 10

Explain how decreased levels of HLA class I on variant cancer cells can (A)enhance or (B)reduce tumor growth.

Accepted Answer

A.Enhancement of tumor growth occurs whe

Question 11

Match between columns
                        Premises: Helicobacter pylori
hepatitis B or C viruses
human papillomavirus
Epstein–Barr virus
human T-cell leukemia virus 1 (HTLV-1)
human immunodeficiency virus (HIV-1)

Accepted Answer

The Answer of Burkitt’s lymphoma and stomach cancers arising from is...

Question 12

Epithelial tumors express MIC proteins on their cell surfaces.
A.Why does this make the tumor cells susceptible to attack by NK cells,γ:δ T cells,and cytotoxic CD8 T cells?
B.How do the tumor cells evade such attack?

Accepted Answer

A.MIC proteins are ligands for the activ

Question 13

A.What are tumor-associated antigens?
B.How do they originate?
C.Give two examples together with the type of tumor they come from.

Accepted Answer

A.Tumor-associated antigens are antigens

Question 14

Chemical and physical agents that increase mutation rates by damaging DNA and increase the likelihood of developing cancer are known as _____.

Accepted Answer

A) oncogens 
B) malignant transformers 
C) antitumor suppressor agents 
D) carcinogens 
E) tumor-associated agents. 
A) oncogens 
B) malignant transformers 
C) antitumor suppressor agents 
D) carcinogens 
E) tumor-associated agents.

Question 15

Which of the following describe types of tumor-associated antigens? (Select all that apply.)

Accepted Answer

A) They are derived from self proteins to which the immune system is not tolerant. 
B) They are derived from proteins encoded by mRNAs that have undergone abnormal post-transcriptional splicing. 
C) They are proteins normally expressed in immunologically privileged sites. 
D) They are proteins expressed at unusually high levels. 
E) They are derived from viral proteins to which the immune system is not tolerant. 
A) They are derived from self proteins to which the immune system is not tolerant. 
B) They are derived from proteins encoded by mRNAs that have undergone abnormal post-transcriptional splicing. 
C) They are proteins normally expressed in immunologically privileged sites. 
D) They are proteins expressed at unusually high levels. 
E) They are derived from viral proteins to which the immune system is not tolerant.

Question 16

Which of the following is not a human monoclonal antibody that is directed at a cell-surface component?

Accepted Answer

A) rituximab 
B) alemtuzumab 
C) ibritumomab 
D) bevacizumab 
E) ipilimumab. 
A) rituximab 
B) alemtuzumab 
C) ibritumomab 
D) bevacizumab 
E) ipilimumab.

Question 17

Cancers develop their own blood supply and become vascularized through _____.

Accepted Answer

A) apoptosis 
B) neoplasia 
C) angiogenesis 
D) metastasis 
E) malignant transformation. 
A) apoptosis 
B) neoplasia 
C) angiogenesis 
D) metastasis 
E) malignant transformation.

Question 18

The efficacy of treating bladder cancer is increased by introducing the BCG vaccine.The vaccine component attributing this antitumor effect is _____,which induces a state of chronic inflammation.

Accepted Answer

A) mycolic acid 
B) unmethylated CpG-containing DNA 
C) lipopolysaccharide 
D) teichoic acid 
E) peptidoglycan. 
A) mycolic acid 
B) unmethylated CpG-containing DNA 
C) lipopolysaccharide 
D) teichoic acid 
E) peptidoglycan.

Question 19

A.What are tumor-specific antigens?
B.How do they originate?
C.Give two examples,together with the type of tumor they come from.

Accepted Answer

A.Tumor-specific antigens are antigens f

Question 20

Examples of tumor suppressor genes include _____.(Select all that apply.)

Accepted Answer

A) APC 
B) RAS 
C) p53 
D) ABL 
E) DCC. 
A) APC 
B) RAS 
C) p53 
D) ABL 
E) DCC.

A mechanism by which cancer cells can evade an immune response involves an alteration in the amount of MIC on the cell surface by

A.What are the two main classes of gene that,if not expressed correctly,can lead to malignant transformation? B.What are the gene products made by each class?

Which cytokines are associated with tumor-induced suppression of the immune response? (Select all that apply.)

Which of the following are true for cancer stem cells? (Select all that apply.)

When the immune system is involved in _____,an appraisal for cancer cells is occurring.

Explain how the immune mechanisms for the detection of cancer cells are (A)similar to and (B)different from those that detect virus-infected cells.

Burkitt's lymphoma is a tumor associated with _ infection,which causes _ to divide uncontrollably.

DNA viruses associated with cancer development include _____.(Select all that apply.)

Explain how decreased levels of HLA class I on variant cancer cells can (A)enhance or (B)reduce tumor growth.

Epithelial tumors express MIC proteins on their cell surfaces. A.Why does this make the tumor cells susceptible to attack by NK cells,γ:δ T cells,and cytotoxic CD8 T cells? B.How do the tumor cells evade such attack?

A.What are tumor-associated antigens? B.How do they originate? C.Give two examples together with the type of tumor they come from.

Chemical and physical agents that increase mutation rates by damaging DNA and increase the likelihood of developing cancer are known as _____.

Which of the following describe types of tumor-associated antigens? (Select all that apply.)

Which of the following is not a human monoclonal antibody that is directed at a cell-surface component?

Cancers develop their own blood supply and become vascularized through _____.

The efficacy of treating bladder cancer is increased by introducing the BCG vaccine.The vaccine component attributing this antitumor effect is _____,which induces a state of chronic inflammation.

A.What are tumor-specific antigens? B.How do they originate? C.Give two examples,together with the type of tumor they come from.

Examples of tumor suppressor genes include _____.(Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Filters

Exam 17: Cancer and Its Interactions With the Immune System

A mechanism by which cancer cells can evade an immune response involves an alteration in the amount of MIC on the cell surface by

A.What are the two main classes of gene that,if not expressed correctly,can lead to malignant transformation? B.What are the gene products made by each class?

Which cytokines are associated with tumor-induced suppression of the immune response? (Select all that apply.)

Which of the following are true for cancer stem cells? (Select all that apply.)

When the immune system is involved in _____,an appraisal for cancer cells is occurring.

Explain how the immune mechanisms for the detection of cancer cells are (A)similar to and (B)different from those that detect virus-infected cells.

Burkitt's lymphoma is a tumor associated with _____ infection,which causes _____ to divide uncontrollably.

DNA viruses associated with cancer development include _____.(Select all that apply.)

Explain how decreased levels of HLA class I on variant cancer cells can (A)enhance or (B)reduce tumor growth.

Epithelial tumors express MIC proteins on their cell surfaces. A.Why does this make the tumor cells susceptible to attack by NK cells,γ:δ T cells,and cytotoxic CD8 T cells? B.How do the tumor cells evade such attack?

A.What are tumor-associated antigens? B.How do they originate? C.Give two examples together with the type of tumor they come from.

Chemical and physical agents that increase mutation rates by damaging DNA and increase the likelihood of developing cancer are known as _____.

Which of the following describe types of tumor-associated antigens? (Select all that apply.)

Which of the following is not a human monoclonal antibody that is directed at a cell-surface component?

Cancers develop their own blood supply and become vascularized through _____.

The efficacy of treating bladder cancer is increased by introducing the BCG vaccine.The vaccine component attributing this antitumor effect is _____,which induces a state of chronic inflammation.

A.What are tumor-specific antigens? B.How do they originate? C.Give two examples,together with the type of tumor they come from.

Examples of tumor suppressor genes include _____.(Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Filters

Burkitt's lymphoma is a tumor associated with _ infection,which causes _ to divide uncontrollably.