Question 1

Which of the following is a mechanism by which tumors can evade immune detection? (Select all that apply.)

Accepted Answer

A) reduction in levels of HLA class I 
B) recruitment of regulatory T cells 
C) enhancement of inflammatory responses 
D) lowering of levels of MIC on the cell surface 
E) increase in levels of CT antigens. 
A) reduction in levels of HLA class I 
B) recruitment of regulatory T cells 
C) enhancement of inflammatory responses 
D) lowering of levels of MIC on the cell surface 
E) increase in levels of CT antigens.

Question 2

Mutagens that increase one's predisposition to developing cancer are called _____.

Accepted Answer

A) carcinogens 
B) tumor antigens 
C) neoplastic mutagens 
D) oncogenes 
E) proto-oncogenes. 
A) carcinogens 
B) tumor antigens 
C) neoplastic mutagens 
D) oncogenes 
E) proto-oncogenes.

Question 3

Which of the following is mismatched?

Accepted Answer

A) tumor suppressor genes: mutated in over 50% of human cancer cases 
B) HTLV-1: an RNA retrovirus associated with adult T-cell leukemia 
C) Helicobacter pylori: bacterial infection associated with colon cancer 
D) sipuleucel-T cell vaccine: treatment for late-stage metastatic prostate cancer 
E) cancer immunosurveillance: recognition and elimination of cancer cells by defense mechanisms. 
A) tumor suppressor genes: mutated in over 50% of human cancer cases 
B) HTLV-1: an RNA retrovirus associated with adult T-cell leukemia 
C) Helicobacter pylori: bacterial infection associated with colon cancer 
D) sipuleucel-T cell vaccine: treatment for late-stage metastatic prostate cancer 
E) cancer immunosurveillance: recognition and elimination of cancer cells by defense mechanisms.

Question 4

_____ is/are commonly associated with the fusion between the BCR gene and the ABL proto-oncogene.

Accepted Answer

A) Non-small cell lung carcinoma 
B) Bladder tumors 
C) Melanoma 
D) Head and neck squamous cell carcinoma 
E) Chronic myelogenous leukemia. 
A) Non-small cell lung carcinoma 
B) Bladder tumors 
C) Melanoma 
D) Head and neck squamous cell carcinoma 
E) Chronic myelogenous leukemia.

Question 5

In domestic dogs and Tasmanian devils,successful passage and growth of tumors through copulation and biting,respectively,are attributed to _____.

Accepted Answer

A) absence of quiescent cancer stem cells in the tumor 
B) limited MHC diversity between animals 
C) repression of tumor-specific antigen expression 
D) repression of tumor-associated antigen expression 
E) lack of regulatory T cells. 
A) absence of quiescent cancer stem cells in the tumor 
B) limited MHC diversity between animals 
C) repression of tumor-specific antigen expression 
D) repression of tumor-associated antigen expression 
E) lack of regulatory T cells.

Question 6

Which of the following pairs are matched correctly? (Select all that apply.)

Accepted Answer

A) myeloma: bone marrow 
B) benign tumor: encapsulation 
C) lymphoma: bone marrow 
D) tumor-associated antigens: proteins expressed only by tumor cells 
E) sarcoma: epithelial cell. 
A) myeloma: bone marrow 
B) benign tumor: encapsulation 
C) lymphoma: bone marrow 
D) tumor-associated antigens: proteins expressed only by tumor cells 
E) sarcoma: epithelial cell.

Question 7

One of the side effects of treating tumor patients with anti-CTLA4 monoclonal antibodies is _____.

Accepted Answer

A) the development of autoimmune disease 
B) lymphoproliferative disorder 
C) increased levels of mutation in tumor cells 
D) upregulation of CT antigens 
E) reactivation of embryonic genes. 
A) the development of autoimmune disease 
B) lymphoproliferative disorder 
C) increased levels of mutation in tumor cells 
D) upregulation of CT antigens 
E) reactivation of embryonic genes.

Question 8

Which of the following is mismatched?

Accepted Answer

A) oncology: diagnosis and treatment of tumors 
B) carcinoma: characteristic cell types found in benign tumors 
C) mutation: changes in DNA involving substitutions,deletions,insertions,recombinations,and translocations 
D) leukemia: cancer of the immune system affecting circulating cells 
E) malignant transformation: gain of ability to form a cancer. 
A) oncology: diagnosis and treatment of tumors 
B) carcinoma: characteristic cell types found in benign tumors 
C) mutation: changes in DNA involving substitutions,deletions,insertions,recombinations,and translocations 
D) leukemia: cancer of the immune system affecting circulating cells 
E) malignant transformation: gain of ability to form a cancer.

Question 9

Bortezomib has all of the following effects except _____.

Accepted Answer

A) reducing the supply of peptides needed for MHC class I transport to the cell surface 
B) inhibiting tumor-cell proliferation 
C) inducing tumor-cell apoptosis 
D) inhibiting proteasome activity 
E) blocking inhibitory KIRs. 
A) reducing the supply of peptides needed for MHC class I transport to the cell surface 
B) inhibiting tumor-cell proliferation 
C) inducing tumor-cell apoptosis 
D) inhibiting proteasome activity 
E) blocking inhibitory KIRs.

Which of the following is a mechanism by which tumors can evade immune detection? (Select all that apply.)

Mutagens that increase one's predisposition to developing cancer are called _____.

Which of the following is mismatched?

_____ is/are commonly associated with the fusion between the BCR gene and the ABL proto-oncogene.

In domestic dogs and Tasmanian devils,successful passage and growth of tumors through copulation and biting,respectively,are attributed to _____.

Which of the following pairs are matched correctly? (Select all that apply.)

One of the side effects of treating tumor patients with anti-CTLA4 monoclonal antibodies is _____.

Which of the following is mismatched?

Bortezomib has all of the following effects except _____.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

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Exam 17: Cancer and Its Interactions With the Immune System

Which of the following is a mechanism by which tumors can evade immune detection? (Select all that apply.)

Mutagens that increase one's predisposition to developing cancer are called _____.

Which of the following is mismatched?

_____ is/are commonly associated with the fusion between the BCR gene and the ABL proto-oncogene.

In domestic dogs and Tasmanian devils,successful passage and growth of tumors through copulation and biting,respectively,are attributed to _____.

Which of the following pairs are matched correctly? (Select all that apply.)

One of the side effects of treating tumor patients with anti-CTLA4 monoclonal antibodies is _____.

Which of the following is mismatched?

Bortezomib has all of the following effects except _____.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Filters