Question 1

Vγ9:Vδ2 T cells differ from α:β T cells in that they _____.(Select all that apply.)

Accepted Answer

A) respond to phosphorylated metabolic intermediates (phosphoantigens)of isoprenoid biosynthesis pathways 
B) bind to lipid antigens presented by CD1 
C) do not carry out gene rearrangement 
D) are not subject to positive and negative selection in the thymus 
E) have limited diversity of V gene rearrangement. 
A) respond to phosphorylated metabolic intermediates (phosphoantigens)of isoprenoid biosynthesis pathways 
B) bind to lipid antigens presented by CD1 
C) do not carry out gene rearrangement 
D) are not subject to positive and negative selection in the thymus 
E) have limited diversity of V gene rearrangement.

Question 2

_____ has/have tyrosine phosphatase activity that interrupts the signaling pathways required for the activation of NK cells.

Accepted Answer

A) SHP-1 
B) MIC proteins 
C) KIR ligands 
D) phosphoantigens 
E) lipid-transfer proteins. 
A) SHP-1 
B) MIC proteins 
C) KIR ligands 
D) phosphoantigens 
E) lipid-transfer proteins.

Question 3

All NK cells express _____.(Select all that apply.)

Accepted Answer

A) CD3 
B) MIC 
C) NKG2D 
D) KIR2DL1 
E) CD56. 
A) CD3 
B) MIC 
C) NKG2D 
D) KIR2DL1 
E) CD56.

Question 4

If,during development,none of the KIRs expressed by a NK cell are able to interact with self-MHC class I molecules,then the NK cell retains expression of _____.

Accepted Answer

A) LILRBI 
B) KIR2DL1 
C) KIR2DL2/3 
D) KIR3DL1 
E) CD94:NKG2A. 
A) LILRBI 
B) KIR2DL1 
C) KIR2DL2/3 
D) KIR3DL1 
E) CD94:NKG2A.

Question 5

Match between columns
                        Premises: Vα24–Jα18:Vβ11
Vγ:Vδ1
Vγ4:Vδ5
Vα7.2–Jα33:Vβ2, -13, or -22.
Vγ9:Vδ2

Accepted Answer

The Answer of phosphoantigens presented by BTN3A1 and lipid antigens is...

Question 6

_____ binds to MIC-A and MIC-B,which are synthesized in response to infection in gut epithelium.(Select all that apply.)

Accepted Answer

A) MHC class I 
B) NKG2D 
C) Vγ:Vδ1 
D) fibroblast growth factor 
E) CD1. 
A) MHC class I 
B) NKG2D 
C) Vγ:Vδ1 
D) fibroblast growth factor 
E) CD1.

Question 7

_____ express a limited range of diversity in their antigen receptors yet can still bind to large groups of pathogens expressing common chemical entities.(Select all that apply.)

Accepted Answer

A) α:βT cells 
B) γ:δT cells 
C) NK cells 
D) NKT cells 
E) B-1 cells. 
A) α:βT cells 
B) γ:δT cells 
C) NK cells 
D) NKT cells 
E) B-1 cells.

Question 8

All of the following describe Vav1 except _____.

Accepted Answer

A) guanine-nucleotide exchange factor 
B) regulated by SHP-1 
C) active when phosphorylated 
D) found on the surface of NK cells 
E) mediates signaling that promotes NK cells' release of cytotoxic granules. 
A) guanine-nucleotide exchange factor 
B) regulated by SHP-1 
C) active when phosphorylated 
D) found on the surface of NK cells 
E) mediates signaling that promotes NK cells' release of cytotoxic granules.

Question 9

Which of the following describe the characteristics of CD94:NKG2A? (Select all that apply.)

Accepted Answer

A) It is an activating receptor of NK cells. 
B) It is an inhibitory receptor of NK cells. 
C) It binds to specific allotypes of HLA-A,-B,and -C heavy chains. 
D) It binds to complexes of leader sequences of HLA-A,-B,and -C heavy chains bound to HLA-E. 
E) It is a member of the killer-cell immunoglobulin-like receptor (KIR)family. 
A) It is an activating receptor of NK cells. 
B) It is an inhibitory receptor of NK cells. 
C) It binds to specific allotypes of HLA-A,-B,and -C heavy chains. 
D) It binds to complexes of leader sequences of HLA-A,-B,and -C heavy chains bound to HLA-E. 
E) It is a member of the killer-cell immunoglobulin-like receptor (KIR)family.

Question 10

CD1a,CD1b,and CD1c _____.(Select all that apply.)

Accepted Answer

A) are highly polymorphic and bind to a variety of pathogen-specific lipids 
B) are encoded within the MHC on chromosome 6 
C) express antigen-binding sites distinct from classical MHC class I molecules 
D) are associated with β2-microglobulin at the surface of antigen-presenting cells 
E) can bind to lipids in the endoplasmic reticulum or in endocytic vesicles. 
A) are highly polymorphic and bind to a variety of pathogen-specific lipids 
B) are encoded within the MHC on chromosome 6 
C) express antigen-binding sites distinct from classical MHC class I molecules 
D) are associated with β2-microglobulin at the surface of antigen-presenting cells 
E) can bind to lipids in the endoplasmic reticulum or in endocytic vesicles.

Question 11

In contrast to CD1d,CD1a,b,and c are not expressed by _____.

Accepted Answer

A) professional antigen-presenting cells 
B) epithelial cells 
C) developing thymocytes. 
A) professional antigen-presenting cells 
B) epithelial cells 
C) developing thymocytes.

Question 12

CD1d differs from CD1a,CD1b,and CD1c in that _____.(Select all that apply.)

Accepted Answer

A) CD1d does not present lipid antigens 
B) CD1d is expressed in a variety of epithelial tissues 
C) CD1d presents antigen to NK T cells 
D) strong memory responses are generated by CD1d 
E) CD1d has a restricted receptor repertoire. 
A) CD1d does not present lipid antigens 
B) CD1d is expressed in a variety of epithelial tissues 
C) CD1d presents antigen to NK T cells 
D) strong memory responses are generated by CD1d 
E) CD1d has a restricted receptor repertoire.

V_γ9:V_δ2 T cells differ from α:β T cells in that they _____.(Select all that apply.)

_____ has/have tyrosine phosphatase activity that interrupts the signaling pathways required for the activation of NK cells.

All NK cells express _____.(Select all that apply.)

If,during development,none of the KIRs expressed by a NK cell are able to interact with self-MHC class I molecules,then the NK cell retains expression of _____.

_____ binds to MIC-A and MIC-B,which are synthesized in response to infection in gut epithelium.(Select all that apply.)

_____ express a limited range of diversity in their antigen receptors yet can still bind to large groups of pathogens expressing common chemical entities.(Select all that apply.)

All of the following describe Vav1 except _____.

Which of the following describe the characteristics of CD94:NKG2A? (Select all that apply.)

CD1a,CD1b,and CD1c _____.(Select all that apply.)

In contrast to CD1d,CD1a,b,and c are not expressed by _____.

CD1d differs from CD1a,CD1b,and CD1c in that _____.(Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 12: Coevolution of Innate and Adaptive Immunity

Vγ9:Vδ2 T cells differ from α:β T cells in that they _____.(Select all that apply.)

_____ has/have tyrosine phosphatase activity that interrupts the signaling pathways required for the activation of NK cells.

All NK cells express _____.(Select all that apply.)

If,during development,none of the KIRs expressed by a NK cell are able to interact with self-MHC class I molecules,then the NK cell retains expression of _____.

_____ binds to MIC-A and MIC-B,which are synthesized in response to infection in gut epithelium.(Select all that apply.)

_____ express a limited range of diversity in their antigen receptors yet can still bind to large groups of pathogens expressing common chemical entities.(Select all that apply.)

All of the following describe Vav1 except _____.

Which of the following describe the characteristics of CD94:NKG2A? (Select all that apply.)

CD1a,CD1b,and CD1c _____.(Select all that apply.)

In contrast to CD1d,CD1a,b,and c are not expressed by _____.

CD1d differs from CD1a,CD1b,and CD1c in that _____.(Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

V_γ9:V_δ2 T cells differ from α:β T cells in that they _____.(Select all that apply.)