Match between columns Premises: T-cell receptor and immunoglobulin genes are encoded on the MHC. T cells require an accessory cell called an antigen-presenting cell,which bears MHC molecules on its surface. T cells and B cells require MHC molecules for the recognition of peptide antigens. The T-cell receptor has structural similarity to an immunoglobulin Fab fragment. T cells and B cells recognize the same types of antigen.

The Answer of True and False is...

Exam 5: Antigen Recognition by T Lymphocytes

One type of bare lymphocyte syndrome is caused by a genetic defect in MHC class II transactivator (CIITA),which results in the inability to synthesize MHC class II and display it on the cell surface.The consequence of this would be that

(Multiple Choice)

4.7/5

(31)

Question 41

A. How many HLA-DR α:β combinations can be made by an individual who is heterozygous at all HLA-DRβ loci, inherits the DRβ haplotype DRB1 from their mother, the DRβ haplotype DRB1, DRB4 from their father, and also inherits different allelic forms of DRA from each parent? B. Repeat this exercise given the same information except that the maternal DRβ haplotype is DRB1, DRB3.

(Essay)

4.9/5

(37)

Question 42

T-cell receptors interact not only with peptide anchored in the peptide-binding groove of MHC molecules,but also with

(Multiple Choice)

4.9/5

(32)

Question 43

A.What is the maximum number of MHC class I and class II molecules that a heterozygous individual could theoretically express? Explain your answer.(Ignore the possibility of MHC class II molecules composed of chains from different isotypes.) B.How does this relatively small number of MHC molecules have the potential to bind the huge number of antigenic peptides encountered in the environment,and what features of a peptide determine whether it will be bound by a given MHC molecule?

(Essay)

4.8/5

(31)

Question 44

Explain how professional antigen-presenting cells optimize antigen presentation to T cells despite the relatively limited capacity of any particular MHC molecule to bind different pathogen-derived peptides.

(Essay)

4.8/5

(34)

Question 45

All of the following are included in the peptide-loading complex except

(Multiple Choice)

4.9/5

(34)

Question 46

Match the term with its description or function.

HLA-F

activated by acidification in phagolysosomes

cathepsin S

expressed only by extravillous trophoblasts

HLA-G

internalization of immunoglobulin:antigen complexes by B cells

Correct Answer:

Verified

HLA-F

cathepsin S

HLA-G

endoplasmic reticulum aminopeptidase (ERAP)

receptor-mediated endocytosis

HLA-DM

ERp57

(Matching)

4.9/5

(38)

Question 47

the following HLA α-chain loci,which one exhibits the highest degree of polymorphism?

(Multiple Choice)

5.0/5

(37)

Question 48

Which of the following is mismatched?

(Multiple Choice)

4.9/5

(37)

Question 49

A.Describe in chronological order the steps of the antigen-processing and antigen-presentation pathways for extracellular pathogens. B.What would be the outcome (i)if invariant chain were defective or missing,or (ii)if HLA-DM were not expressed?

(Essay)

4.8/5

(41)

Question 50

The degradation of pathogen proteins into smaller fragments called peptides is a process commonly referred to as

(Multiple Choice)

4.7/5

(33)

Question 51

Match the answer that best describes the function .More than one answer may be correct.

participate in peptide loading of MHC class II molecules

HLA-F

present antigen to CD4 T cells

HLA-DP, HLA-DQ, HLA-DR

form ligands for receptors on NK cells

HLA-A, HLA-B, HLA-C

Correct Answer:

Verified

participate in peptide loading of MHC class II molecules

present antigen to CD4 T cells

form ligands for receptors on NK cells

an intracellular, monomorphic MHC class I isotype whose function is unknown

present antigen to CD8 T cells

(Matching)

4.8/5

(40)

Question 52

Which of the following best describes the function of tapasin?

(Multiple Choice)

4.9/5

(28)

Question 53

Match the term with its complement.

T-cell receptor β-chain gene

positioned in the T-cell receptor α-chain locus between Vα and Jα gene segments

CD3 complex

located on chromosome 7

CD4

four extracellular domains

Correct Answer:

Verified

T-cell receptor β-chain gene

CD3 complex

CD4

T-cell receptor γ-chain gene

T-cell receptor δ-chain gene

(Matching)

4.8/5

(29)

Question 54

All of the following are oligomorphic except

(Multiple Choice)

4.8/5

(33)

Question 55

The most variable parts of the T-cell receptor are

(Multiple Choice)

4.8/5

(22)

Question 56

Describe (A)five ways in which T-cell receptors are similar to immunoglobulins,and (B)five ways in which they are different (other than the way in which they recognize antigen).

(Essay)

4.8/5

(31)

Question 57

T-cell receptors do not undergo isotype switching.Suggest a possible reason for this.

(Essay)

4.9/5

(25)

Question 58

MHC class II molecules are made up of two chains called _,whose function is to bind peptides and present them to _ T cells:

(Multiple Choice)

4.9/5

(25)

Question 59

Indicate whether each of the following statements regarding T cells is true (T)or false (F).

T-cell receptor and immunoglobulin genes are encoded on the MHC.

True

T cells require an accessory cell called an antigen-presenting cell,which bears MHC molecules on its surface.

False

T cells and B cells require MHC molecules for the recognition of peptide antigens.

Correct Answer:

Verified

T-cell receptor and immunoglobulin genes are encoded on the MHC.

T cells require an accessory cell called an antigen-presenting cell,which bears MHC molecules on its surface.

(Matching)

4.8/5

(37)

Question 60

One type of bare lymphocyte syndrome is caused by a genetic defect in MHC class II transactivator (CIITA),which results in the inability to synthesize MHC class II and display it on the cell surface.The consequence of this would be that

T-cell receptors interact not only with peptide anchored in the peptide-binding groove of MHC molecules,but also with

Explain how professional antigen-presenting cells optimize antigen presentation to T cells despite the relatively limited capacity of any particular MHC molecule to bind different pathogen-derived peptides.

All of the following are included in the peptide-loading complex except

the following HLA α-chain loci,which one exhibits the highest degree of polymorphism?

Which of the following is mismatched?

A.Describe in chronological order the steps of the antigen-processing and antigen-presentation pathways for extracellular pathogens. B.What would be the outcome (i)if invariant chain were defective or missing,or (ii)if HLA-DM were not expressed?

The degradation of pathogen proteins into smaller fragments called peptides is a process commonly referred to as

Which of the following best describes the function of tapasin?

All of the following are oligomorphic except

The most variable parts of the T-cell receptor are

Describe (A)five ways in which T-cell receptors are similar to immunoglobulins,and (B)five ways in which they are different (other than the way in which they recognize antigen).

T-cell receptors do not undergo isotype switching.Suggest a possible reason for this.

MHC class II molecules are made up of two chains called _,whose function is to bind peptides and present them to _ T cells:

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 5: Antigen Recognition by T Lymphocytes

One type of bare lymphocyte syndrome is caused by a genetic defect in MHC class II transactivator (CIITA),which results in the inability to synthesize MHC class II and display it on the cell surface.The consequence of this would be that

T-cell receptors interact not only with peptide anchored in the peptide-binding groove of MHC molecules,but also with

Explain how professional antigen-presenting cells optimize antigen presentation to T cells despite the relatively limited capacity of any particular MHC molecule to bind different pathogen-derived peptides.

All of the following are included in the peptide-loading complex except

the following HLA α-chain loci,which one exhibits the highest degree of polymorphism?

Which of the following is mismatched?

A.Describe in chronological order the steps of the antigen-processing and antigen-presentation pathways for extracellular pathogens. B.What would be the outcome (i)if invariant chain were defective or missing,or (ii)if HLA-DM were not expressed?

The degradation of pathogen proteins into smaller fragments called peptides is a process commonly referred to as

Which of the following best describes the function of tapasin?

All of the following are oligomorphic except

The most variable parts of the T-cell receptor are

Describe (A)five ways in which T-cell receptors are similar to immunoglobulins,and (B)five ways in which they are different (other than the way in which they recognize antigen).

T-cell receptors do not undergo isotype switching.Suggest a possible reason for this.

MHC class II molecules are made up of two chains called _______,whose function is to bind peptides and present them to _______ T cells:

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

MHC class II molecules are made up of two chains called _,whose function is to bind peptides and present them to _ T cells: