Exam 5: Antigen Recognition by T Lymphocytes

Peptides that bind to a particular MHC isoform usually have either the same or chemically similar amino acids at two to three key positions that hold the peptide tightly in the peptide-binding groove of the MHC molecule.These amino acids are called _____ and the combination of these key residues is known as its _____.

Antigen processing involves the breakdown of protein antigens and the subsequent association of peptide fragments on the surface of antigen-presenting cells with

Which of the following statements regarding T-cell receptor recognition of antigen is correct?

The primary reason for transplant rejections is due to differences in _____ between donor and recipient.

A.What is the difference between MHC variation due to multigene families and that due to allelic polymorphism? B.How does MHC variation due to multigene families and allelic polymorphism influence the antigens that a person's T cells can recognize?

What is meant by the terms (A)antigen processing and (B)antigen presentation? (C)Why are these processes required before T cells can be activated?

In reference to the interaction between T-cell receptors and their corresponding ligands,which of the following statements is correct?

To which domain of MHC class II does CD4 bind?

In terms of V,D,and J segment arrangement,the T-cell receptor α-chain locus resembles the immunoglobulin _______ locus,whereas the T-cell receptor β-chain locus resembles the immunoglobulin _______ locus:

To which domain of MHC class I does CD8 bind?

During T-cell receptor _____-gene rearrangement,two D segments may be used in the final rearranged gene sequence,thereby increasing overall variability of this chain.

Which of the following describes the sequence of events involved in processing of peptides that will be presented as antigen with MHC class I?

If viewing the three-dimensional structure of a T-cell receptor from the side,with the T-cell membrane at the bottom and the receptor pointing upwards,which of the following is inconsistent with experimental data?

In the context of MHC isoforms,what is the difference between balancing selection and directional selection?

Provide an explanation of why it is believed that MHC class I genes are the evolutionary ancestors of MHC class II genes.

IgG possesses _______ binding sites for antigen,and the T-cell receptor possesses _______ binding sites for antigen:

The CDR3 loops of the T-cell receptor contact the _______:

Identify which of the following statements is true regarding the transporter associated with antigen processing (TAP).

All of the following are primarily associated with CD4 T-cell function except

T-cell subpopulations are specialized to combat _______ pathogens,whereas CD4 T-cell subpopulations are specialized to combat _______ pathogens: