Exam 8: Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

Which GTP-binding protein is associated with clathrin-coated vesicles and helps to initiate the formation of the coat?

What is responsible for degrading misfolded proteins in the cytoplasm?

What sugar is usually removed from the N-linked core oligosaccharide chains on proteins in the Golgi complex as opposed to the glucose residues trimmed off in the ER?

Late endosomes are also referred to as _______.

Why does targeting glucocerebrosidase to lysosomes in macrophages serve as a treatment for Gaucher's disease?

What information does the use of siRNAs provide?

Which type of cells below is not known for its extensively developed SER?

Most vesicles budding from the Golgi body have a fuzzy,electron-dense coat on their ______ surface.The coat appears to be made of _______.

The two separate (basic)categories of uptake of extracellular materials into cytoplasmic vesicles are ______ and ______.

Which of the following has not been identified as a phosphoinositide?

Most proteins destined for the chloroplast are synthesized with a removable ________ called the ______.

Typically,receptors for hormones or growth factors are destroyed during endocytosis,leading to a reduction in the cell's sensitivity to further stimulation by that particular hormone or growth factor.This is a mechanism by which cells regulate their ability to respond to extracellular messengers.What is it called?

TB 8.066 The ER reportedly contains sensors that monitor the concentration of unfolded or misfolded proteins in the lumen.One proposal suggests that the sensors are normally kept in an inactive state by ______,particularly ______.

TB 8.034 Blöbel,Sabatini and Dobberstein proposed that the site of protein synthesis is determined by information contained in the N-terminal portion of the protein,the first part to emerge from the ribosome.What did they call their proposal?

Which phosphoinositide is localized at the late endosome boundary membrane?

Which model of Golgi complex formation suggests that the cisternae of a Golgi stack remain in place as stable compartments held together by a protein scaffold,while the cargo is shuttled through the Golgi via vesicles that bud from one compartment and fuse with a neighboring one?

Where are v-SNAREs and t-SNARES found,respectively?

In general,diseases that result from a deficiency of a single lysosomal enzyme are called ________.

How do Rabs appear to associate with membranes?

TB 8.014 You incubate liposomes with a series of purified proteins normally found in the coats of cell transport vesicles.After adding one of them to the liposome mixture,budding of vesicles from the liposomes began.What does this mean?