Exam 15: Transplantation of Tissues and Organs

Explain why,in principle,an organ transplanted from any donor other than an identical twin is almost certain to be rejected in the absence of any other treatment.

A.Identify three general classes of drug that are used to suppress acute transplant rejection,and provide examples of each class. B.What side-effects and toxic effects are associated with each class of drug?

(A)What is a cross-match test? (B)Why is it carried out? (C)How is it carried out?

What is the probability that a sibling will be able to provide a HLA-haploidentical kidney for transplantation?

We learned in Chapter 5 that the benefit of having and expressing multiple MHC class I and class II genes is that it increases the number and variety of pathogen-derived peptide antigens that can potentially be presented to T cells.If more is better,then why has natural selection not favored the evolution of more than three genes each for MHC class I and MHC class II?

Which of the following exerts its effect by inhibiting the activation of calcineurin by calcium and thereby interferes with nuclear translocation of NFAT? (Select all that apply.)

The risk of _____ is the primary complication in bone marrow transplants.

How do the clinical objectives of transplantation differ from those of vaccination?