Exam 13: The Cardiovascular System: Cardiac Function

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Given end- diastolic volume = 130 mL and end- systolic volume = 50 mL, what is the stroke volume and ejection fraction?

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Cardiac output is in part determined by changes in heart rate. Describe the factors that are responsible for inducing changes in heart rate.

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Heart rate is one of the determinants of cardiac output. The heart rate is determined by the pacemaker cells. Typically, heart beats originate from the sinoatrial node. However, other sites along the conduction pathway also contain pacemaker cells that, while they tend to have a slower rate of depolarization, can also cause contraction. The ability of these cells to generate an action potential involves the slow depolarization driven by the closure of K+ channels, the opening of non- selective cation channels (funny channels)and the ultimate opening of the Ca2+ channels. The autonomic nervous system is the primary modulator of heart rate. This means that activity of sympathetic and parasympathetic neurons must be able to alter the slope of the slow depolarization of the pacemaker cells. There are sympathetic and parasympathetic neurons that innervate the sinoatrial node, atrioventricular node, and other regions of the conduction pathway that can alter heart rate. Increases in sympathetic activity will increase the slope of the slow depolarization, causing heart rate to increase, whereas parasympathetic activity will decrease the slope of the slow depolarization, causing heart rate to decrease. A number of hormones like epinephrine, glucagon, thyroid hormone, and others act in a manner similar to sympathetic activity. Each of the hormones elevates heart rate by increasing the slope of the slow depolarization. Heart rate independent of the autonomic nervous system tends to be around 100 bts/min. Since normal heart rate for adults tends to be less than that, the heart is said to be under resting parasympathetic tone. However, this is not to say that the sympathetic nervous system is not active.

Although blood is a fluid, nearly half its volume is composed of cells. The most numerous cells are . The remainder of the cells are _ , which help the body defend itself against foreign particles and microorganisms.

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The second heart sound coincides with the beginning of which period in the cardiac cycle?

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The increased aortic pressure that occurs during systole reflects a(n)

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The preload is approximately the same as the pressure.

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Normal resting heart rate is around 70 beats per minute due to the SA node. If the SA node fails, what would you expect the heart beats per minute to be?

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If damage to the AV node slowed down conduction through this tissue, what would be observed on an ECG?

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Which component of an ECG represents ventricular diastole?

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The pathway by which action potentials from the sinoatrial node travel through the heart is important for the normal function of the heart. Describe the conduction pathway of the heart and how that path corresponds to electrical events in an ECG reading.

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Which statement best describes parallel flow in the circulatory system?

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The circulatory system consists of two divisions and is supplied with blood by different sides of the heart. The right heart supplies blood to the _ circuit, whereas the left heart supplies blood to the circuit.

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During isovolumetric contraction, which chamber has the greatest pressure?

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Which of the following describes second- degree heart block?

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Which of the following best describes the effect of sympathetic activity on ventricular contractile cells?

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The muscular wall of the right ventricle is thicker than that of the left ventricle because it develops a greater pressure in order to deliver blood to the organs of the body.

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The end- diastolic volume minus the end- systolic volume is the

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Under resting conditions, heart rate is primarily under the control of what control system?

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The primary site of exchange between blood and interstitial fluid occurs across what type of blood vessel?

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Which of the following components of an ECG represents ventricular depolarization?

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