Question 1

The KM is

Accepted Answer

A)  equal to the product concentration at initial reaction conditions. 
B)  equal to the substrate concentration when the reaction rate is half its maximal value. 
C)  proportional to the standard free energy. 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  equal to the product concentration at initial reaction conditions. 
B)  equal to the substrate concentration when the reaction rate is half its maximal value. 
C)  proportional to the standard free energy. 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 2

. What is the upper limit of kcat / KM?

Accepted Answer

The diffusion-controlled interaction of

Question 3

How are the types of inhibition kinetically distinguishable?

Accepted Answer

Competitive inhibition can be overcome b

Question 4

Riboflavin is a water-soluble organic substance that is not synthesized by humans. Metabolically, it is chemically converted into a substance called flavin adenine dinucleotide, which is required by succinate dehydrogenase. Which of the following statements is most correct?

Accepted Answer

A)  Riboflavin is a coenzyme. 
B)  Flavin adenine dinucleotide is a vitamin. 
C)  Succinate dehydrogenase is a coenzyme. 
D)  Flavin adenine dinucleotide is a coenzyme. Succinate dehydrogenase is a vitamin. 
A)  Riboflavin is a coenzyme. 
B)  Flavin adenine dinucleotide is a vitamin. 
C)  Succinate dehydrogenase is a coenzyme. 
D)  Flavin adenine dinucleotide is a coenzyme. Succinate dehydrogenase is a vitamin.

Question 5

When ΔG for a system is zero, the system is at ______________________.

Accepted Answer

The answer of When ΔG for a system is zero,...

Question 6

A __________________ inhibitor often has a structure similar to the substrate and often reversibly binds to the active site of the enzyme but can be displaced by substrate.

Accepted Answer

The answer of A __________________ inhibitor often has a structure...

Question 7

What type(s) of inhibition can be reversed?

Accepted Answer

A)  competitive 
B)  noncompetitive 
C)  mixed 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  competitive 
B)  noncompetitive 
C)  mixed 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 8

What term describes the substance that is bound by an enzyme and converted to product?

Accepted Answer

A)  inhibitor 
B)  substrate 
C)  coenzyme 
D)  prosthetic group 
E)  cofactor 
A)  inhibitor 
B)  substrate 
C)  coenzyme 
D)  prosthetic group 
E)  cofactor

Question 9

How is the substrate bound to the active site?

Accepted Answer

The active site is a small part of the t

Question 10

. Enzyme populations are studied with the use of ensemble methods. How would the data differ from a single-enzyme study?

Accepted Answer

In the ensemble method study, you would

Question 11

The formula K'eq = 10 - $\Delta$ G ° ' /1.36 indicates the relationship between

Accepted Answer

A)  the free energy and the equilibrium constant. 
B)  the reaction equilibrium and the isomerization rate. 
C)  the equilibrium constant and standard free energy. 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  the free energy and the equilibrium constant. 
B)  the reaction equilibrium and the isomerization rate. 
C)  the equilibrium constant and standard free energy. 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 12

Examples of cofactors include

Accepted Answer

A)  Zn2+, Mg2+, and Ni2+. 
B)  biotin and thiamine pyrophosphate. 
C)  pyridoxal phosphate and coenzyme A. 
D)  biotin and thiamine pyrophosphate and pyridoxal phosphate and coenzyme A 
E)  All of the answers are correct. 
A)  Zn2+, Mg2+, and Ni2+. 
B)  biotin and thiamine pyrophosphate. 
C)  pyridoxal phosphate and coenzyme A. 
D)  biotin and thiamine pyrophosphate and pyridoxal phosphate and coenzyme A 
E)  All of the answers are correct.

Question 13

What are transition-state analogs?

Accepted Answer

These potent inhibitors mimic the struct

Question 14

A reaction can occur spontaneously only if ΔG is __________________.

Accepted Answer

The answer of A reaction can occur spontaneously only if...

Question 15

The straight-line kinetic plot of 1/ V0 versus 1/S is called a ________________________.

Accepted Answer

Lineweaver

Question 16

When the kcat / KM ratio is at its upper limit, it is referred to as

Accepted Answer

A)  Circe limits. 
B)  Michaelis rate. 
C)  kinetic perfection. 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  Circe limits. 
B)  Michaelis rate. 
C)  kinetic perfection. 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 17

When substrate concentration is much greater than KM, the rate of catalysis is almost equal to

Accepted Answer

A)  Kd. 
B)  kcat / KM.  
C)  Vmax. 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  Kd. 
B)  kcat / KM.  
C)  Vmax. 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 18

Enzymes accelerate the rate of a chemical reaction by __________________ the activation energy of the reaction.

Accepted Answer

The answer of Enzymes accelerate the rate of a chemical...

Question 19

The site on an enzyme where the reaction that is catalyzed by the enzyme occurs is the _____.

Accepted Answer

A)  binding site 
B)  substrate site 
C)  allosteric site 
D)  regulatory site 
E)  active site 
A)  binding site 
B)  substrate site 
C)  allosteric site 
D)  regulatory site 
E)  active site

Question 20

Which of the following is true?

Accepted Answer

A)  Enzymes force reactions to proceed in only one direction. 
B)  Enzymes alter the equilibrium of the reaction. 
C)  Enzymes alter the standard free energy of the reaction. 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  Enzymes force reactions to proceed in only one direction. 
B)  Enzymes alter the equilibrium of the reaction. 
C)  Enzymes alter the standard free energy of the reaction. 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Exam 8: Enzymes: Basic Concepts and Kinetics

The KM is

. What is the upper limit of kcat / KM?

How are the types of inhibition kinetically distinguishable?

Riboflavin is a water-soluble organic substance that is not synthesized by humans. Metabolically, it is chemically converted into a substance called flavin adenine dinucleotide, which is required by succinate dehydrogenase. Which of the following statements is most correct?

When ΔG for a system is zero, the system is at ______________________.

A __________________ inhibitor often has a structure similar to the substrate and often reversibly binds to the active site of the enzyme but can be displaced by substrate.

What type(s) of inhibition can be reversed?

What term describes the substance that is bound by an enzyme and converted to product?

How is the substrate bound to the active site?

. Enzyme populations are studied with the use of ensemble methods. How would the data differ from a single-enzyme study?

The formula K'eq = 10 - Δ\DeltaΔ G ° ' /1.36 indicates the relationship between

Examples of cofactors include

What are transition-state analogs?

A reaction can occur spontaneously only if ΔG is __________________.

The straight-line kinetic plot of 1/ V0 versus 1/S is called a ________________________.

When the kcat / KM ratio is at its upper limit, it is referred to as

When substrate concentration is much greater than KM, the rate of catalysis is almost equal to

Enzymes accelerate the rate of a chemical reaction by __________________ the activation energy of the reaction.

The site on an enzyme where the reaction that is catalyzed by the enzyme occurs is the _____.

Which of the following is true?

Biochemistry: an Evolving Science

Protein Composition and Structure

Exploring Proteins and Proteomes

DNA, RNA, and the Flow of Genetic Information

Exploring Genes and Genomes

Exploring Evolution and Bioinformatics

Hemoglobin: a Portrait of a Protein in Action

Oxidative Phosphorylation

Catalytic Strategies

Regulatory Strategies

Carbohydrates

Lipids and Cell Membranes

Membrane Channels and Pumps

Signal-Transduction Pathways

Metabolism: Basic Concepts and Design

Glycolysis and Gluconeogenesis

The Citric Acid Cycle

The Light Reactions of Photosynthesis

The Calvin Cycle and the Pentose Phosphate Pathway

Glycogen Metabolism

Fatty Acid Metabolism

Protein Turnover and Amino Acid Catabolism

The Biosynthesis of Amino Acids

Nucleotide Biosynthesis

Biosynthesis of Membrane Lipids and Steroids

The Integration of Metabolism

DNA Replication, Repair, and Recombination

Rna Synthesis and Processing

Protein Synthesis

The Control of Gene Expression in Prokaryotes

The Control of Gene Expression in Eukaryotes

Sensory Systems

The Immune System

Molecular Motors

Drug Development

Filters

The K_M is

. What is the upper limit of k_cat / K_M?

The formula K'_eq = 10 ^- ^$\Delta$ ^G ^° ^' ^/1.36 indicates the relationship between

The straight-line kinetic plot of 1/ V₀ versus 1/S is called a ________________________.

When the k_cat / K_M ratio is at its upper limit, it is referred to as

When substrate concentration is much greater than K_M, the rate of catalysis is almost equal to