Question 1

Cyclosporine A binding to cyclophilin blocks T cell activation by:

Accepted Answer

A)  Inhibiting calcineurin and NFAT 
B)  Inhibiting RAP by binding to FKBP-12 
C)  Inhibiting IL-2 binding to the IL-2 receptor 
D)  Inhibiting calcineurin and protein kinase C (PK
C)  
A)  Inhibiting calcineurin and NFAT 
B)  Inhibiting RAP by binding to FKBP-12 
C)  Inhibiting IL-2 binding to the IL-2 receptor 
D)  Inhibiting calcineurin and protein kinase C (PK
C)  A

Question 2

The Rac/JNK pathway activates which signaling component?

Accepted Answer

A)  Fos 
B)  Jun 
C)  AP-1 
D)  NF-kB 
A)  Fos 
B)  Jun 
C)  AP-1 
D)  NF-kB B

Question 3

The activation of the TCR through interaction with either MHC class I or class II molecules leads to signaling pathways that activate protein synthesis of:

Accepted Answer

A)  IL-1 
B)  IL-2 
C)  TNF 
D)  ZAP-70 
A)  IL-1 
B)  IL-2 
C)  TNF 
D)  ZAP-70 B

Question 4

The major defect in X-linked severe combined immunodeficiency (SCID) is:

Accepted Answer

A)  Inability to produce IL-2 
B)  Lack of ZAP-70 protein kinase 
C)  Inability to produce B or T cells 
D)  Lack of g-chain in interleukin receptors 
A)  Inability to produce IL-2 
B)  Lack of ZAP-70 protein kinase 
C)  Inability to produce B or T cells 
D)  Lack of g-chain in interleukin receptors

Question 5

What is one reason that basiliximab or daclizumab would be a better option for renal transplant patients than cyclosporine A?

Accepted Answer

A)  Cyclosporine causes renal toxicity. 
B)  Cyclosporine stimulates the immune system. 
C)  Basiliximab and daclizumab increase renal function. 
D)  Basiliximab and daclizumab inhibit the whole immune system, not just T cells. 
A)  Cyclosporine causes renal toxicity. 
B)  Cyclosporine stimulates the immune system. 
C)  Basiliximab and daclizumab increase renal function. 
D)  Basiliximab and daclizumab inhibit the whole immune system, not just T cells.

Question 6

Which of the following is an example of autocrine signaling?

Accepted Answer

A)  An NK cell responding to IL-12 produced by a macrophage. 
B)  A macrophage responding to TNF made by the same macrophage. 
C)  A T helper cell responding to IL-2 produced by a neighboring T cell. 
D)  A neutrophil responding to IL-1 produced by vascular endothelial cell. 
A)  An NK cell responding to IL-12 produced by a macrophage. 
B)  A macrophage responding to TNF made by the same macrophage. 
C)  A T helper cell responding to IL-2 produced by a neighboring T cell. 
D)  A neutrophil responding to IL-1 produced by vascular endothelial cell.

Question 7

What is the purpose of adaptor proteins in signal transduction?

Accepted Answer

A)  Activate transcription 
B)  Facilitate dimerization of receptors 
C)  Anchor the receptor to the membrane 
D)  Carry the signal from the membrane into the cytoplasm 
A)  Activate transcription 
B)  Facilitate dimerization of receptors 
C)  Anchor the receptor to the membrane 
D)  Carry the signal from the membrane into the cytoplasm

Question 8

The downstream signaling target of CD28/B7 activation is:

Accepted Answer

A)  NF-kB 
B)  PIP2/IP3 
C)  Rac/JNK 
D)  PLCg1/DAG/PKC 
A)  NF-kB 
B)  PIP2/IP3 
C)  Rac/JNK 
D)  PLCg1/DAG/PKC

Question 9

The activation of inositol-1,4,5-triphosphate (IP₃) signaling results in:

Accepted Answer

A)  Activation of NF-kB signaling 
B)  Release of intracellular calcium 
C)  Phosphorylation of downstream targets 
D)  Formation of the immunological synapse 
A)  Activation of NF-kB signaling 
B)  Release of intracellular calcium 
C)  Phosphorylation of downstream targets 
D)  Formation of the immunological synapse

Question 10

Which of the following is/are part of the high affinity IL-2 receptor? 
I. a-Chains
II. b-Chains
III. g-Chains

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Cyclosporine A binding to cyclophilin blocks T cell activation by:

The Rac/JNK pathway activates which signaling component?

The activation of the TCR through interaction with either MHC class I or class II molecules leads to signaling pathways that activate protein synthesis of:

The major defect in X-linked severe combined immunodeficiency (SCID) is:

What is one reason that basiliximab or daclizumab would be a better option for renal transplant patients than cyclosporine A?

Which of the following is an example of autocrine signaling?

What is the purpose of adaptor proteins in signal transduction?

The downstream signaling target of CD28/B7 activation is:

The activation of inositol-1,4,5-triphosphate (IP₃) signaling results in:

Which of the following is/are part of the high affinity IL-2 receptor? I. a-Chains II. b-Chains III. g-Chains

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 7: Intracellular Signaling and T Cell Activation

Cyclosporine A binding to cyclophilin blocks T cell activation by:

The Rac/JNK pathway activates which signaling component?

The activation of the TCR through interaction with either MHC class I or class II molecules leads to signaling pathways that activate protein synthesis of:

The major defect in X-linked severe combined immunodeficiency (SCID) is:

What is one reason that basiliximab or daclizumab would be a better option for renal transplant patients than cyclosporine A?

Which of the following is an example of autocrine signaling?

What is the purpose of adaptor proteins in signal transduction?

The downstream signaling target of CD28/B7 activation is:

The activation of inositol-1,4,5-triphosphate (IP₃) signaling results in:

Which of the following is/are part of the high affinity IL-2 receptor? I. a-Chains II. b-Chains III. g-Chains

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters