Question 1

Proteins from _______________ genes combine with RNase to form the viral reverse transcriptase complex?

Accepted Answer

A)  Tat and rev 
B)  Pol and vpr 
C)  Vpu and nef 
D)  Gag and env 
A)  Tat and rev 
B)  Pol and vpr 
C)  Vpu and nef 
D)  Gag and env B

Question 2

Which of the following agents is/are entry/fusion inhibitor(s) administered to treat HIV infection? 
I. Maraviroc
II. Enfuvirtide
III. Zidovudine

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III C

Question 3

After the human immunodeficiency virus (HIV) binds to CD4 on a T cell, what other molecule does it need to bind for entry into the host cell?

Accepted Answer

A)  H-1 
B)  H-2 
C)  CCR5 
D)  CXCR4 
A)  H-1 
B)  H-2 
C)  CCR5 
D)  CXCR4 D

Question 4

What is the mechanism of HIV-induced death of follicular dendritic cells (FDCs)?

Accepted Answer

A)  TNF released by CD8 cells 
B)  Lysis following virus production 
C)  Fas expression upregulated on FDCs 
D)  Perforin/granzyme-induced apoptosis 
A)  TNF released by CD8 cells 
B)  Lysis following virus production 
C)  Fas expression upregulated on FDCs 
D)  Perforin/granzyme-induced apoptosis

Question 5

Which of the following drugs binds directly to HIV reverse transcriptase to inhibit activity?

Accepted Answer

A)  Nevirapine 
B)  Zalcitabine 
C)  Raltegravir 
D)  Didanosine 
A)  Nevirapine 
B)  Zalcitabine 
C)  Raltegravir 
D)  Didanosine

Question 6

The most important enzyme involved in transcription of HIV RNA into DNA is:

Accepted Answer

A)  Integrase 
B)  RNA polymerase 
C)  Late phase protease 
D)  Reverse transcriptase 
A)  Integrase 
B)  RNA polymerase 
C)  Late phase protease 
D)  Reverse transcriptase

Question 7

While the exact mechanism of CD4 T cell destruction in HIV infection is not completely known, what is the cause of the ultimate depletion of CD4 T cells?

Accepted Answer

A)  Stem cell depletion 
B)  Virus damaged cells are phagocytosed 
C)  Drugs used to treat HIV deplete CD4 T cells 
D)  CD8 T cells and NK cells kill all infected cells 
A)  Stem cell depletion 
B)  Virus damaged cells are phagocytosed 
C)  Drugs used to treat HIV deplete CD4 T cells 
D)  CD8 T cells and NK cells kill all infected cells

Question 8

What protein protects viral RNA from degradation by host cell cytoplasmic enzymes?

Accepted Answer

A)  gp120 
B)  RNase 
C)  Vif protein 
D)  Rev protein 
A)  gp120 
B)  RNase 
C)  Vif protein 
D)  Rev protein

Question 9

During the initial infection with HIV, the virus is concentrated in the:

Accepted Answer

A)  Thymus 
B)  Bone marrow 
C)  Lymph nodes 
D)  Site of exposure 
A)  Thymus 
B)  Bone marrow 
C)  Lymph nodes 
D)  Site of exposure

Question 10

Which class of drug results in the formation of disorganized viral capsids that form noninfectious viral progeny?

Accepted Answer

A)  Fusion inhibitors 
B)  Protease inhibitors 
C)  Integrase inhibitors 
D)  Reverse transcriptase inhibitors 
A)  Fusion inhibitors 
B)  Protease inhibitors 
C)  Integrase inhibitors 
D)  Reverse transcriptase inhibitors

Proteins from _______________ genes combine with RNase to form the viral reverse transcriptase complex?

Which of the following agents is/are entry/fusion inhibitor(s) administered to treat HIV infection? I. Maraviroc II. Enfuvirtide III. Zidovudine

After the human immunodeficiency virus (HIV) binds to CD4 on a T cell, what other molecule does it need to bind for entry into the host cell?

What is the mechanism of HIV-induced death of follicular dendritic cells (FDCs)?

Which of the following drugs binds directly to HIV reverse transcriptase to inhibit activity?

The most important enzyme involved in transcription of HIV RNA into DNA is:

While the exact mechanism of CD4 T cell destruction in HIV infection is not completely known, what is the cause of the ultimate depletion of CD4 T cells?

What protein protects viral RNA from degradation by host cell cytoplasmic enzymes?

During the initial infection with HIV, the virus is concentrated in the:

Which class of drug results in the formation of disorganized viral capsids that form noninfectious viral progeny?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

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Exam 26: Acquired Immune Deficiency Syndrome

Proteins from _______________ genes combine with RNase to form the viral reverse transcriptase complex?

Which of the following agents is/are entry/fusion inhibitor(s) administered to treat HIV infection? I. Maraviroc II. Enfuvirtide III. Zidovudine

After the human immunodeficiency virus (HIV) binds to CD4 on a T cell, what other molecule does it need to bind for entry into the host cell?

What is the mechanism of HIV-induced death of follicular dendritic cells (FDCs)?

Which of the following drugs binds directly to HIV reverse transcriptase to inhibit activity?

The most important enzyme involved in transcription of HIV RNA into DNA is:

While the exact mechanism of CD4 T cell destruction in HIV infection is not completely known, what is the cause of the ultimate depletion of CD4 T cells?

What protein protects viral RNA from degradation by host cell cytoplasmic enzymes?

During the initial infection with HIV, the virus is concentrated in the:

Which class of drug results in the formation of disorganized viral capsids that form noninfectious viral progeny?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Filters