Question 1

Which methods of antigen administration elicit a vigorous immune response? 
I. Intravenous
II. Intramuscular
III. Subcutaneous

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III D

Question 2

Immune responses to idiotypes located outside the complementarity-determining regions (CDRs) result in:

Accepted Answer

A)  Increases in autoantibody production 
B)  Downregulation of autoreactive B cells 
C)  Increases in activated regulatory T cells 
D)  Downregulation of MHC class II molecules on APCs 
A)  Increases in autoantibody production 
B)  Downregulation of autoreactive B cells 
C)  Increases in activated regulatory T cells 
D)  Downregulation of MHC class II molecules on APCs B

Question 3

What is the outcome of matrilysin cleaving FasL from an activated T cell?

Accepted Answer

A)  Soluble FasL is degraded and the activated T cell survives. 
B)  Soluble FasL binds to Fas and triggers the death of the activated T cell. 
C)  Soluble FasL binds to Fas and triggers the death of the regulatory T cell. 
D)  Soluble FasL is disseminated and causes widespread cell death in both immune cells and infected host cells. 
A)  Soluble FasL is degraded and the activated T cell survives. 
B)  Soluble FasL binds to Fas and triggers the death of the activated T cell. 
C)  Soluble FasL binds to Fas and triggers the death of the regulatory T cell. 
D)  Soluble FasL is disseminated and causes widespread cell death in both immune cells and infected host cells. B

Question 4

What is the difference between an idiotype and an idiotope?

Accepted Answer

A)  Idiotopes are on the antibody and idiotypes are on the antigen. 
B)  Idiotopes can only react with T cells and idiotypes can only react with B cells. 
C)  Idiotopes are an amino acid sequence, and idiotypes are groups of idiotopes. 
D)  Idiotopes and idiotypes have the same sequence but in different locations on the antibody. 
A)  Idiotopes are on the antibody and idiotypes are on the antigen. 
B)  Idiotopes can only react with T cells and idiotypes can only react with B cells. 
C)  Idiotopes are an amino acid sequence, and idiotypes are groups of idiotopes. 
D)  Idiotopes and idiotypes have the same sequence but in different locations on the antibody.

Question 5

What is the immune response to high doses of antigen?

Accepted Answer

A)  T cells are inactivated. 
B)  B cells are inactivated. 
C)  NK cells are inactivated. 
D)  Macrophages are inactivated. 
A)  T cells are inactivated. 
B)  B cells are inactivated. 
C)  NK cells are inactivated. 
D)  Macrophages are inactivated.

Question 6

Antigen-induced cell death (AICD) is mediated by:
I- Fas:FasL interactions
II- Perforin and granzymes
III- TNF-mediated cell death

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Question 7

Which of the following is the outcome of T cell interaction with immature dendritic cells that do not express costimulatory molecules?

Accepted Answer

A)  Anergic T cell response 
B)  Only CD8 T cells respond 
C)  Only CD4 T cells respond 
D)  Uncontrolled T cell response 
A)  Anergic T cell response 
B)  Only CD8 T cells respond 
C)  Only CD4 T cells respond 
D)  Uncontrolled T cell response

Question 8

How do CD8 regulatory T cells identify CD4 cells that should be killed?

Accepted Answer

A)  FasL is cleaved from CD4 T cell. 
B)  Qa-1 is present on CD4 T cell surface. 
C)  The high affinity IL-2 receptor is stimulated. 
D)  Antigen expression is required on MHC class II molecules. 
A)  FasL is cleaved from CD4 T cell. 
B)  Qa-1 is present on CD4 T cell surface. 
C)  The high affinity IL-2 receptor is stimulated. 
D)  Antigen expression is required on MHC class II molecules.

Question 9

How does the "hole in the T cell repertoire" model explain why some individuals may fail to respond to an antigen?

Accepted Answer

A)  MHC class II molecules differ in their ability to bind and process antigen. 
B)  The TCR is lacking appropriate accessory molecules to fully transduce signals. 
C)  Some individuals lack a lymphocyte with a TCR that recognizes a specific antigen. 
D)  Antigen is inappropriately presented on MHC class I molecules rather than class II molecules. 
A)  MHC class II molecules differ in their ability to bind and process antigen. 
B)  The TCR is lacking appropriate accessory molecules to fully transduce signals. 
C)  Some individuals lack a lymphocyte with a TCR that recognizes a specific antigen. 
D)  Antigen is inappropriately presented on MHC class I molecules rather than class II molecules.

Question 10

Defects in Fas:FasL engagement and signaling may contribute to which disease?

Accepted Answer

A)  Graves' disease 
B)  Rheumatoid arthritis 
C)  Type II diabetes mellitus 
D)  Systemic lupus erythematosus (SL
E)  
A)  Graves' disease 
B)  Rheumatoid arthritis 
C)  Type II diabetes mellitus 
D)  Systemic lupus erythematosus (SL
E)

Which methods of antigen administration elicit a vigorous immune response? I. Intravenous II. Intramuscular III. Subcutaneous

Immune responses to idiotypes located outside the complementarity-determining regions (CDRs) result in:

What is the outcome of matrilysin cleaving FasL from an activated T cell?

What is the difference between an idiotype and an idiotope?

What is the immune response to high doses of antigen?

Antigen-induced cell death (AICD) is mediated by: I- Fas:FasL interactions II- Perforin and granzymes III- TNF-mediated cell death

Which of the following is the outcome of T cell interaction with immature dendritic cells that do not express costimulatory molecules?

How do CD8 regulatory T cells identify CD4 cells that should be killed?

How does the "hole in the T cell repertoire" model explain why some individuals may fail to respond to an antigen?

Defects in Fas:FasL engagement and signaling may contribute to which disease?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 22: Factors That Influence the Immune Response

Which methods of antigen administration elicit a vigorous immune response? I. Intravenous II. Intramuscular III. Subcutaneous

Immune responses to idiotypes located outside the complementarity-determining regions (CDRs) result in:

What is the outcome of matrilysin cleaving FasL from an activated T cell?

What is the difference between an idiotype and an idiotope?

What is the immune response to high doses of antigen?

Antigen-induced cell death (AICD) is mediated by: I- Fas:FasL interactions II- Perforin and granzymes III- TNF-mediated cell death

Which of the following is the outcome of T cell interaction with immature dendritic cells that do not express costimulatory molecules?

How do CD8 regulatory T cells identify CD4 cells that should be killed?

How does the "hole in the T cell repertoire" model explain why some individuals may fail to respond to an antigen?

Defects in Fas:FasL engagement and signaling may contribute to which disease?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters