Question 1

MHC molecules containing beta-2-microglobulin:

Accepted Answer

A)  contain alpha and beta transmembrane polypeptides. 
B)  participate in the activation of CD4 T cells. 
C)  are determined by MHC-A, MHC-B, and MHC-C genes. 
D)  are determined by MHC-DR genes. 
A)  contain alpha and beta transmembrane polypeptides. 
B)  participate in the activation of CD4 T cells. 
C)  are determined by MHC-A, MHC-B, and MHC-C genes. 
D)  are determined by MHC-DR genes. C

Question 2

If a person has a reaction to poison ivy,this is caused by:

Accepted Answer

A)  a hapten complexing with a tissue protein. 
B)  a heterophile antigen. 
C)  a T-independent antigen. 
D)  exposure to an adjuvant. 
A)  a hapten complexing with a tissue protein. 
B)  a heterophile antigen. 
C)  a T-independent antigen. 
D)  exposure to an adjuvant. A

Question 3

Which of the following would be the most effective immunogen?

Accepted Answer

A)  One that is genetically foreign and has a single epitope 
B)  One with a molecular weight of less than 10,000 Da 
C)  One with multiple epitopes with many specificities 
D)  One with multiple epitopes with a single repeated specificity 
A)  One that is genetically foreign and has a single epitope 
B)  One with a molecular weight of less than 10,000 Da 
C)  One with multiple epitopes with many specificities 
D)  One with multiple epitopes with a single repeated specificity C

Question 4

The inheritance of certain MHC antigens can result in which of the following?

Accepted Answer

A)  Increased resistance to certain infectious organisms 
B)  Predisposition to particular autoimmune diseases 
C)  Diminished immune responses to particular antigens 
D)  All of the above 
A)  Increased resistance to certain infectious organisms 
B)  Predisposition to particular autoimmune diseases 
C)  Diminished immune responses to particular antigens 
D)  All of the above

Question 5

The purpose of the invariant chain is to block the peptide-binding site of:

Accepted Answer

A)  antibody molecules. 
B)  class II MHC molecules. 
C)  class I MHC molecules. 
D)  T-cell receptors. 
A)  antibody molecules. 
B)  class II MHC molecules. 
C)  class I MHC molecules. 
D)  T-cell receptors.

Question 6

The term "human leukocyte antigen" is synonymous with:

Accepted Answer

A)  allele. 
B)  haplotype. 
C)  major histocompatibility complex. 
D)  chromosome. 
A)  allele. 
B)  haplotype. 
C)  major histocompatibility complex. 
D)  chromosome.

Question 7

A processed antigen first encounters and binds to class I MHC molecules in the:

Accepted Answer

A)  nucleus. 
B)  endoplasmic reticulum. 
C)  endosomal compartment. 
D)  membrane surface. 
A)  nucleus. 
B)  endoplasmic reticulum. 
C)  endosomal compartment. 
D)  membrane surface.

Question 8

Which of the following is NOT a characteristic shared by class I and class II MHC molecules?

Accepted Answer

A)  Expressed co-dominantly 
B)  Involved in antigen recognition 
C)  Members of the immunoglobulin superfamily 
D)  Expressed constitutively on all nucleated cells 
A)  Expressed co-dominantly 
B)  Involved in antigen recognition 
C)  Members of the immunoglobulin superfamily 
D)  Expressed constitutively on all nucleated cells

Question 9

An antigenic determinant is also called:

Accepted Answer

A)  an immunogen. 
B)  an epitope. 
C)  an antibody. 
D)  a polysaccharide. 
A)  an immunogen. 
B)  an epitope. 
C)  an antibody. 
D)  a polysaccharide.

Question 10

T cells are capable of recognizing:

Accepted Answer

A)  conformational epitopes. 
B)  native (nondegraded) peptides. 
C)  degraded peptides. 
D)  haptens. 
A)  conformational epitopes. 
B)  native (nondegraded) peptides. 
C)  degraded peptides. 
D)  haptens.

Question 11

The antigens that bind MHC class II antigens are first "processed" by:

Accepted Answer

A)  the proteasome. 
B)  the endoplasmic reticulum. 
C)  transporters associated with antigen processing. 
D)  enzymes in the endosome. 
A)  the proteasome. 
B)  the endoplasmic reticulum. 
C)  transporters associated with antigen processing. 
D)  enzymes in the endosome.

Question 12

A processed antigen first encounters and binds to MHC class II molecules in the:

Accepted Answer

A)  nucleus. 
B)  endoplasmic reticulum. 
C)  endosomal compartment. 
D)  membrane surface. 
A)  nucleus. 
B)  endoplasmic reticulum. 
C)  endosomal compartment. 
D)  membrane surface.

Question 13

If a mother is MHC A3A14/B5B15/Cw3Cw4 and her child is A3A9/B5B27/Cw4Cw7,which of the following men is the most likely candidate for the father?

Accepted Answer

A)  A5A9/B5B27/Cw3Cw7 
B)  A9A11/B15B21/Cw1Cw4 
C)  A4A15/B2B27/Cw1Cw5 
D)  A5A9/B17B27/Cw3Cw5 
A)  A5A9/B5B27/Cw3Cw7 
B)  A9A11/B15B21/Cw1Cw4 
C)  A4A15/B2B27/Cw1Cw5 
D)  A5A9/B17B27/Cw3Cw5

Question 14

In antigen processing,the function of transporters associated with antigen-processing proteins is to:

Accepted Answer

A)  help digest large proteins. 
B)  bind to MHC class II molecules in the endoplasmic reticulum. 
C)  transport digested proteins to MHC class I molecules. 
D)  recognize and digest exogenous protein. 
A)  help digest large proteins. 
B)  bind to MHC class II molecules in the endoplasmic reticulum. 
C)  transport digested proteins to MHC class I molecules. 
D)  recognize and digest exogenous protein.

Question 15

A macromolecule that is capable of eliciting an immune response in an immunocompetent host is called:

Accepted Answer

A)  an antigen. 
B)  an antibody. 
C)  a hapten. 
D)  an acute-phase reactant. 
A)  an antigen. 
B)  an antibody. 
C)  a hapten. 
D)  an acute-phase reactant.

Question 16

Which of the following is likely to be the most immunogenic?

Accepted Answer

A)  A lipid with a molecular weight of 50,000 Da 
B)  A polysaccharide with a molecular weight of 40,000 Da 
C)  A protein with a molecular weight of 45,000 Da 
D)  A nucleic acid with a molecular weight of 60,000 Da 
A)  A lipid with a molecular weight of 50,000 Da 
B)  A polysaccharide with a molecular weight of 40,000 Da 
C)  A protein with a molecular weight of 45,000 Da 
D)  A nucleic acid with a molecular weight of 60,000 Da

Question 17

Which of the following is a low-molecular-weight molecule that has one binding site for an antibody?

Accepted Answer

A)  Antigen 
B)  Hapten 
C)  Immunogen 
D)  Adjuvant 
A)  Antigen 
B)  Hapten 
C)  Immunogen 
D)  Adjuvant

Question 18

A determinant site on an antigen that is produced by the folding of the primary chain is known as a:

Accepted Answer

A)  conformational epitope. 
B)  linear epitope. 
C)  hapten. 
D)  monovalent epitope. 
A)  conformational epitope. 
B)  linear epitope. 
C)  hapten. 
D)  monovalent epitope.

Question 19

Which option best describes MHC class I antigens?

Accepted Answer

A)  They are recognized by helper T cells. 
B)  They are found on all nucleated cells. 
C)  They combine with exogenous antigen. 
D)  They are coded for on chromosome 9. 
A)  They are recognized by helper T cells. 
B)  They are found on all nucleated cells. 
C)  They combine with exogenous antigen. 
D)  They are coded for on chromosome 9.

Question 20

The ability to respond to antigen depends on which of the following factors?

Accepted Answer

A)  Age 
B)  Proper nutrition 
C)  Genetic predisposition 
D)  All of the above 
A)  Age 
B)  Proper nutrition 
C)  Genetic predisposition 
D)  All of the above

Exam 2: Nature of Antigens and the Major Histocompatibility Complex

MHC molecules containing beta-2-microglobulin:

If a person has a reaction to poison ivy,this is caused by:

Which of the following would be the most effective immunogen?

The inheritance of certain MHC antigens can result in which of the following?

The purpose of the invariant chain is to block the peptide-binding site of:

The term "human leukocyte antigen" is synonymous with:

A processed antigen first encounters and binds to class I MHC molecules in the:

Which of the following is NOT a characteristic shared by class I and class II MHC molecules?

An antigenic determinant is also called:

T cells are capable of recognizing:

The antigens that bind MHC class II antigens are first "processed" by:

A processed antigen first encounters and binds to MHC class II molecules in the:

If a mother is MHC A3A14/B5B15/Cw3Cw4 and her child is A3A9/B5B27/Cw4Cw7,which of the following men is the most likely candidate for the father?

In antigen processing,the function of transporters associated with antigen-processing proteins is to:

A macromolecule that is capable of eliciting an immune response in an immunocompetent host is called:

Which of the following is likely to be the most immunogenic?

Which of the following is a low-molecular-weight molecule that has one binding site for an antibody?

A determinant site on an antigen that is produced by the folding of the primary chain is known as a:

Which option best describes MHC class I antigens?

The ability to respond to antigen depends on which of the following factors?

Introduction to Immunity and the Immune System

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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