Question 1

An example of a tumor-specific antigen is the BCR/ABL protein for chronic myelogenous leukemia.

Accepted Answer

A) True 
 B)False  True

Question 2

A proto-oncogene is a normal gene that has a positive influence on cell proliferation.

Accepted Answer

A) True 
 B)False  True

Question 3

Match the tumor marker to its associated disease.

-Alpha-fetoprotein

Accepted Answer

A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers 
A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers A

Question 4

Match the tumor marker to its associated disease.

-Carcinoembryonic antigen

Accepted Answer

A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers 
A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers

Question 5

Tumor-associated antigens are expressed only in tumor cells.

Accepted Answer

A) True 
 B)False

Question 6

A tumor-specific antigen is:

Accepted Answer

A)  a general marker for all known human tumors. 
B)  a specific marker for leukemias. 
C)  unique to the tumor of an individual patient. 
D)  nonspecific to all patient populations. 
A)  a general marker for all known human tumors. 
B)  a specific marker for leukemias. 
C)  unique to the tumor of an individual patient. 
D)  nonspecific to all patient populations.

Question 7

Carcinogenesis is thought to be initiated by the exposure of the host to factors such as bacteria.

Accepted Answer

A) True 
 B)False

Question 8

In which of the following conditions would you not see an increase in alpha-fetoprotein?

Accepted Answer

A)  Pregnancy 
B)  Hepatocellular carcinoma 
C)  Hepatitis 
D)  Hypercholesteremia 
A)  Pregnancy 
B)  Hepatocellular carcinoma 
C)  Hepatitis 
D)  Hypercholesteremia

Question 9

Match the tumor marker to its associated disease.

-Cancer antigen 125

Accepted Answer

A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers 
A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers

Question 10

Which of the following is a clinical application for tumor markers?

Accepted Answer

A)  Screening 
B)  Diagnosis 
C)  Monitoring 
D)  All of the above 
A)  Screening 
B)  Diagnosis 
C)  Monitoring 
D)  All of the above

Question 11

A tumor that is classified as malignant is described as:

Accepted Answer

A)  a disorganized mass that is not encapsulated and can invade nearby organs. 
B)  a slow-growing, organized mass of encapsulated cells. 
C)  usually confined to the skin. 
D)  an area of swelling that shows no abnormal growth of cells. 
A)  a disorganized mass that is not encapsulated and can invade nearby organs. 
B)  a slow-growing, organized mass of encapsulated cells. 
C)  usually confined to the skin. 
D)  an area of swelling that shows no abnormal growth of cells.

Question 12

What is the definition of a carcinoma?

Accepted Answer

A)  A cancer that is derived from skin or epithelial linings of internal organs or glands 
B)  A cancer that is derived from muscle, fat, and soft tissues 
C)  A cancer that is derived from blood and lymphatic systems 
D)  A cancer that is derived from brain and spinal tissue 
A)  A cancer that is derived from skin or epithelial linings of internal organs or glands 
B)  A cancer that is derived from muscle, fat, and soft tissues 
C)  A cancer that is derived from blood and lymphatic systems 
D)  A cancer that is derived from brain and spinal tissue

Question 13

Match the tumor marker to its associated disease.

-Cancer antigen 19-9

Accepted Answer

A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers 
A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers

Question 14

What is the definition of a sarcoma?

Accepted Answer

A)  A cancer that is derived from skin or epithelial linings of internal organs or glands 
B)  A cancer that is derived from muscle, bone, fat or soft tissues 
C)  A cancer that is derived from blood and lymphatic systems 
D)  A cancer that is derived from brain and spinal tissue 
A)  A cancer that is derived from skin or epithelial linings of internal organs or glands 
B)  A cancer that is derived from muscle, bone, fat or soft tissues 
C)  A cancer that is derived from blood and lymphatic systems 
D)  A cancer that is derived from brain and spinal tissue

Question 15

A woman who has a history of ovarian cancer in her family goes to her physician for a "cancer test." What is the test that is most likely to be positive if the woman has ovarian cancer?

Accepted Answer

A)  Carcinoembryonic antigen 
B)  Alpha-fetoprotein 
C)  Cancer antigen 125 
D)  Human chorionic gonadotropin 
A)  Carcinoembryonic antigen 
B)  Alpha-fetoprotein 
C)  Cancer antigen 125 
D)  Human chorionic gonadotropin

Question 16

Match the tumor marker to its associated disease.

-HER-2

Accepted Answer

A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers 
A) Hepatocellular carcinoma 
B) Ovarian cancer 
C) Colorectal, breast, or lung cancer 
D) Breast cancer only 
E) Pancreatic and gastrointestinal cancers

Exam 17: Tumor Immunology

An example of a tumor-specific antigen is the BCR/ABL protein for chronic myelogenous leukemia.

A proto-oncogene is a normal gene that has a positive influence on cell proliferation.

Match the tumor marker to its associated disease. -Alpha-fetoprotein

Match the tumor marker to its associated disease. -Carcinoembryonic antigen

Tumor-associated antigens are expressed only in tumor cells.

A tumor-specific antigen is:

Carcinogenesis is thought to be initiated by the exposure of the host to factors such as bacteria.

In which of the following conditions would you not see an increase in alpha-fetoprotein?

Match the tumor marker to its associated disease. -Cancer antigen 125

Which of the following is a clinical application for tumor markers?

A tumor that is classified as malignant is described as:

What is the definition of a carcinoma?

Match the tumor marker to its associated disease. -Cancer antigen 19-9

What is the definition of a sarcoma?

A woman who has a history of ovarian cancer in her family goes to her physician for a "cancer test." What is the test that is most likely to be positive if the woman has ovarian cancer?

Match the tumor marker to its associated disease. -HER-2

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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