Question 1

Identify the statement about monoclonal antibodies that is true.

Accepted Answer

A)  They all recognize numerous antigens. 
B)  They arise from a single B cell. 
C)  They are used for testing only and not as therapeutic agents. 
D)  They are found only in cancerous states. 
A)  They all recognize numerous antigens. 
B)  They arise from a single B cell. 
C)  They are used for testing only and not as therapeutic agents. 
D)  They are found only in cancerous states. B

Question 2

Which immunoglobulin can cross the placenta?

Accepted Answer

A)  IgM 
B)  IgE 
C)  IgA 
D)  IgG 
A)  IgM 
B)  IgE 
C)  IgA 
D)  IgG D

Question 3

The valence of an IgG antibody molecule is:

Accepted Answer

A)  1. 
B)  2. 
C)  4. 
D)  10. 
A)  1. 
B)  2. 
C)  4. 
D)  10. B

Question 4

Which is a characteristic of IgM?

Accepted Answer

A)  It can cross the placenta. 
B)  It is able to fix complement. 
C)  It increases greatly in the secondary response. 
D)  It can bind only two antigens. 
A)  It can cross the placenta. 
B)  It is able to fix complement. 
C)  It increases greatly in the secondary response. 
D)  It can bind only two antigens.

Question 5

Where on an antibody molecule does combination with antigen take place?

Accepted Answer

A)  Variable region 
B)  Constant region 
C)  Hinge region 
D)  Fc region 
A)  Variable region 
B)  Constant region 
C)  Hinge region 
D)  Fc region

Question 6

What is the main function of IgD?

Accepted Answer

A)  It helps in class switching. 
B)  It is a primary response antibody. 
C)  It protects mucous membranes. 
D)  It offers protection to newborns. 
A)  It helps in class switching. 
B)  It is a primary response antibody. 
C)  It protects mucous membranes. 
D)  It offers protection to newborns.

Question 7

Identify the main purpose of the secretory component of IgA.

Accepted Answer

A)  Transports across endothelial cells 
B)  Combines with antigen 
C)  Joins the two monomers 
D)  Involved in class switching 
A)  Transports across endothelial cells 
B)  Combines with antigen 
C)  Joins the two monomers 
D)  Involved in class switching

Question 8

Which option represents an isotype of a heavy chain?

Accepted Answer

A)  Kappa 
B)  Beta 
C)  Epsilon 
D)  Lambda 
A)  Kappa 
B)  Beta 
C)  Epsilon 
D)  Lambda

Question 9

Which antibody is best able to agglutinate and fix complement?

Accepted Answer

A)  IgA 
B)  IgM 
C)  IgG 
D)  IgE 
A)  IgA 
B)  IgM 
C)  IgG 
D)  IgE

Question 10

Which of the following pairs represents light chains of antibody molecules?

Accepted Answer

A)  Kappa and epsilon 
B)  Gamma and lambda 
C)  Lambda and kappa 
D)  Alpha and beta 
A)  Kappa and epsilon 
B)  Gamma and lambda 
C)  Lambda and kappa 
D)  Alpha and beta

Question 11

Which option best describes monoclonal antibody?

Accepted Answer

A)  Antibody made against multiple epitopes 
B)  Antibody made by a variety of B cells 
C)  Antibody made from a single antibody-producing cell 
D)  All antibody of any one particular class 
A)  Antibody made against multiple epitopes 
B)  Antibody made by a variety of B cells 
C)  Antibody made from a single antibody-producing cell 
D)  All antibody of any one particular class

Question 12

The combination of a plasma cell fused to a myeloma cell is called a:

Accepted Answer

A)  melanoma. 
B)  hybridoma. 
C)  mycetoma. 
D)  myeloma. 
A)  melanoma. 
B)  hybridoma. 
C)  mycetoma. 
D)  myeloma.

Question 13

The antigen specificity of a B cell is determined:

Accepted Answer

A)  after interaction with antigen. 
B)  by H- and L-chain variable-region sequences. 
C)  only by the L chain. 
D)  after isotype switching. 
A)  after interaction with antigen. 
B)  by H- and L-chain variable-region sequences. 
C)  only by the L chain. 
D)  after isotype switching.

Question 14

Kappa or lambda light chains:

Accepted Answer

A)  are encoded on the same chromosome. 
B)  associate with only one type of heavy chain at a time. 
C)  can be expressed by the same B cell. 
D)  are expressed by a pre-B cell. 
A)  are encoded on the same chromosome. 
B)  associate with only one type of heavy chain at a time. 
C)  can be expressed by the same B cell. 
D)  are expressed by a pre-B cell.

Question 15

In serum electrophoresis conducted at pH 8.6,which protein group migrates the fastest?

Accepted Answer

A)  Albumin 
B)  Alpha-1 globulin 
C)  Alpha-2 globulin 
D)  Gamma globulin 
A)  Albumin 
B)  Alpha-1 globulin 
C)  Alpha-2 globulin 
D)  Gamma globulin

Question 16

The theory that lymphocytes are preprogrammed to respond to a particular type of antigen best describes:

Accepted Answer

A)  the clonal selection theory. 
B)  Ehrlich's side-chain theory. 
C)  the spontaneous generation theory. 
D)  Edelman's antibody-formation theory. 
A)  the clonal selection theory. 
B)  Ehrlich's side-chain theory. 
C)  the spontaneous generation theory. 
D)  Edelman's antibody-formation theory.

Question 17

In serum protein electrophoresis,which band contains the immunoglobulins?

Accepted Answer

A)  Alpha-1 
B)  Alpha-2 
C)  Beta 
D)  Gamma 
A)  Alpha-1 
B)  Alpha-2 
C)  Beta 
D)  Gamma

Question 18

The antibody that appears first in an immune response and is a pentamer with a molecular weight of 900,000 Da best describes:

Accepted Answer

A)  IgM. 
B)  IgD. 
C)  IgA. 
D)  IgG. 
A)  IgM. 
B)  IgD. 
C)  IgA. 
D)  IgG.

Question 19

Which immunoglobulin is found in only trace amounts in the serum?

Accepted Answer

A)  IgM 
B)  IgG 
C)  IgD 
D)  IgA 
A)  IgM 
B)  IgG 
C)  IgD 
D)  IgA

Question 20

Which class makes up 70% to 80% of total serum immunoglobulins?

Accepted Answer

A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE 
A)  IgA 
B)  IgG 
C)  IgM 
D)  IgE

Exam 5: Antibody Structure and Function

Identify the statement about monoclonal antibodies that is true.

Which immunoglobulin can cross the placenta?

The valence of an IgG antibody molecule is:

Which is a characteristic of IgM?

Where on an antibody molecule does combination with antigen take place?

What is the main function of IgD?

Identify the main purpose of the secretory component of IgA.

Which option represents an isotype of a heavy chain?

Which antibody is best able to agglutinate and fix complement?

Which of the following pairs represents light chains of antibody molecules?

Which option best describes monoclonal antibody?

The combination of a plasma cell fused to a myeloma cell is called a:

The antigen specificity of a B cell is determined:

Kappa or lambda light chains:

In serum electrophoresis conducted at pH 8.6,which protein group migrates the fastest?

The theory that lymphocytes are preprogrammed to respond to a particular type of antigen best describes:

In serum protein electrophoresis,which band contains the immunoglobulins?

The antibody that appears first in an immune response and is a pentamer with a molecular weight of 900,000 Da best describes:

Which immunoglobulin is found in only trace amounts in the serum?

Which class makes up 70% to 80% of total serum immunoglobulins?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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