Question 1

Which complement factor polymerizes to cause lysis of a foreign cell?

Accepted Answer

A)  C5 
B)  C6 
C)  C8 
D)  C9 
A)  C5 
B)  C6 
C)  C8 
D)  C9 D

Question 2

Which factor must be associated with factor H to inactivate complement components?

Accepted Answer

A)  C1INH 
B)  Factor I 
C)  DAF 
D)  CR1 
A)  C1INH 
B)  Factor I 
C)  DAF 
D)  CR1 B

Question 3

The target recognition molecule of the lectin pathway that initiates complement activation is:

Accepted Answer

A)  C1q. 
B)  C4. 
C)  C5b6789. 
D)  mannose-binding lectin. 
A)  C1q. 
B)  C4. 
C)  C5b6789. 
D)  mannose-binding lectin. D

Question 4

Which of the following can activate the alternative complement pathway?

Accepted Answer

A)  IgG 
B)  mannose-binding lectin 
C)  C3b 
D)  C1q 
A)  IgG 
B)  mannose-binding lectin 
C)  C3b 
D)  C1q

Question 5

Which complement protein is the key intermediate in all pathways?

Accepted Answer

A)  C4 
B)  C2 
C)  C3 
D)  C1 
A)  C4 
B)  C2 
C)  C3 
D)  C1

Question 6

Which of the following has perforin-like activity?

Accepted Answer

A)  IgG 
B)  IFN-gamma 
C)  C5b6789 
D)  C3b 
A)  IgG 
B)  IFN-gamma 
C)  C5b6789 
D)  C3b

Question 7

The alternative and classical pathway C3 convertases are destabilized as a means of downregulating complement function.One molecule that performs this function is:

Accepted Answer

A)  C1 esterase inhibitor. 
B)  membrane cofactor protein. 
C)  S protein 
D)  CD59. 
A)  C1 esterase inhibitor. 
B)  membrane cofactor protein. 
C)  S protein 
D)  CD59.

Question 8

C5a promotes which of the following actions?

Accepted Answer

A)  Phagocytosis of target cells 
B)  Inactivation of the alternative pathway 
C)  Increased vascular permeability 
D)  Beginning of the membrane attack unit 
A)  Phagocytosis of target cells 
B)  Inactivation of the alternative pathway 
C)  Increased vascular permeability 
D)  Beginning of the membrane attack unit

Question 9

Which complement component is found in both the classic and alternative pathways?

Accepted Answer

A)  C1 
B)  C2 
C)  Factor B 
D)  C3 
A)  C1 
B)  C2 
C)  Factor B 
D)  C3

Question 10

In the alternative pathway,C3 and C5 convertase are stabilized by which of the following?

Accepted Answer

A)  Properdin 
B)  Factor B 
C)  Factor I 
D)  C4 
A)  Properdin 
B)  Factor B 
C)  Factor I 
D)  C4

Question 11

What is cleaved by C3bBb?

Accepted Answer

A)  C3 
B)  C5 
C)  C6 
A)  C3 
B)  C5 
C)  C6

Question 12

Which complement receptor is found on mature B cells?

Accepted Answer

A)  CR1 
B)  CR2 
C)  CR3 
D)  CR4 
A)  CR1 
B)  CR2 
C)  CR3 
D)  CR4

Question 13

The membrane attack unit of complement is represented by which of the following?

Accepted Answer

A)  C2a4b3b 
B)  C1qrs 
C)  C3bBbP 
D)  C5b6789 
A)  C2a4b3b 
B)  C1qrs 
C)  C3bBbP 
D)  C5b6789

Question 14

C5b6789 functions in:

Accepted Answer

A)  target cell lysis. 
B)  recognition of antigen. 
C)  chemotaxis. 
D)  complement inhibition. 
A)  target cell lysis. 
B)  recognition of antigen. 
C)  chemotaxis. 
D)  complement inhibition.

Question 15

Identify the alternative pathway trigger.

Accepted Answer

A)  Fungal cell walls 
B)  Mannose-binding protein 
C)  Antigen-MHC complexes 
D)  Antigen-antibody combination 
A)  Fungal cell walls 
B)  Mannose-binding protein 
C)  Antigen-MHC complexes 
D)  Antigen-antibody combination

Question 16

A system of serum proteins that interact to enhance the immune response by producing cytolytic,chemotactic,and other effects best describes:

Accepted Answer

A)  complement. 
B)  fibrinogen. 
C)  haptoglobin. 
D)  CRP. 
A)  complement. 
B)  fibrinogen. 
C)  haptoglobin. 
D)  CRP.

Question 17

Which of the following complement components has chemotactic activity?

Accepted Answer

A)  C3b 
B)  C3a 
C)  C1qrs 
D)  C5b6789 
A)  C3b 
B)  C3a 
C)  C1qrs 
D)  C5b6789

Question 18

What is cleaved by C4b2a3b?

Accepted Answer

A)  C3 
B)  C4 
C)  C5 
D)  C6 
A)  C3 
B)  C4 
C)  C5 
D)  C6

Question 19

Dense deposits of C3 breakdown products can accumulate in the kidneys because of:

Accepted Answer

A)  properdin deficiency. 
B)  inadequate C3b-mediated opsonization. 
C)  membrane attack complex formation. 
D)  autoantibodies that bind C3bBb. 
A)  properdin deficiency. 
B)  inadequate C3b-mediated opsonization. 
C)  membrane attack complex formation. 
D)  autoantibodies that bind C3bBb.

Question 20

Which factor helps to dissociate C3b from red blood cells?

Accepted Answer

A)  Factor B 
B)  DAF 
C)  C1INH 
D)  C5 
A)  Factor B 
B)  DAF 
C)  C1INH 
D)  C5

Exam 7: Complement System

Which complement factor polymerizes to cause lysis of a foreign cell?

Which factor must be associated with factor H to inactivate complement components?

The target recognition molecule of the lectin pathway that initiates complement activation is:

Which of the following can activate the alternative complement pathway?

Which complement protein is the key intermediate in all pathways?

Which of the following has perforin-like activity?

The alternative and classical pathway C3 convertases are destabilized as a means of downregulating complement function.One molecule that performs this function is:

C5a promotes which of the following actions?

Which complement component is found in both the classic and alternative pathways?

In the alternative pathway,C3 and C5 convertase are stabilized by which of the following?

What is cleaved by C3bBb?

Which complement receptor is found on mature B cells?

The membrane attack unit of complement is represented by which of the following?

C5b6789 functions in:

Identify the alternative pathway trigger.

A system of serum proteins that interact to enhance the immune response by producing cytolytic,chemotactic,and other effects best describes:

Which of the following complement components has chemotactic activity?

What is cleaved by C4b2a3b?

Dense deposits of C3 breakdown products can accumulate in the kidneys because of:

Which factor helps to dissociate C3b from red blood cells?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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