Question 1

The purpose of negative selection of B cells is to:

Accepted Answer

A)  eliminate B cells that don't express mu. 
B)  prevent activation of B cells in the bone marrow. 
C)  direct more B cells to become plasma cells. 
D)  eliminate B cells that are specific for self-antigens. 
A)  eliminate B cells that don't express mu. 
B)  prevent activation of B cells in the bone marrow. 
C)  direct more B cells to become plasma cells. 
D)  eliminate B cells that are specific for self-antigens. D

Question 2

A cell that can recall previous contact with a particular antigen so that subsequent exposure leads to a more rapid and more effective immune response than the first encounter is which type of cell?

Accepted Answer

A)  Memory lymphocyte 
B)  Effector lymphocyte 
C)  Plasma cell 
D)  Stem cell 
A)  Memory lymphocyte 
B)  Effector lymphocyte 
C)  Plasma cell 
D)  Stem cell A

Question 3

Perforin and granzymes are used by which cells to kill target cells?

Accepted Answer

A)  CD8 T cells and CD4 T cells 
B)  CD4 T cells and natural killer cells 
C)  Natural killer cells and B cells 
D)  CD8 T cells and natural killer cells 
A)  CD8 T cells and CD4 T cells 
B)  CD4 T cells and natural killer cells 
C)  Natural killer cells and B cells 
D)  CD8 T cells and natural killer cells D

Question 4

Which type of helper T cell promotes cytotoxic activity?

Accepted Answer

A)  Th1 
B)  Th2 
C)  Treg 
D)  Th9 
A)  Th1 
B)  Th2 
C)  Treg 
D)  Th9

Question 5

Which cells are responsible for killing virally infected host cells and tumor cells?

Accepted Answer

A)  CD4 T cells 
B)  CD8 T cells 
C)  B cells 
D)  Plasma cells 
A)  CD4 T cells 
B)  CD8 T cells 
C)  B cells 
D)  Plasma cells

Question 6

A critical receptor involved in the second signal for T-dependent B-cell activation is:

Accepted Answer

A)  CD3. 
B)  CD19. 
C)  CD40. 
D)  surface IgM. 
A)  CD3. 
B)  CD19. 
C)  CD40. 
D)  surface IgM.

Question 7

Which of the following cells that participate in cell-mediated immunity are antigen specific and directly cytotoxic for target cells?

Accepted Answer

A)  Macrophages 
B)  Th1 cells 
C)  Cytotoxic T cells 
D)  Natural killer cells 
A)  Macrophages 
B)  Th1 cells 
C)  Cytotoxic T cells 
D)  Natural killer cells

Question 8

The cells that primarily function by secreting large amounts of cytokines are:

Accepted Answer

A)  plasma cells. 
B)  B cells. 
C)  T helper cells. 
D)  cytotoxic T cells. 
A)  plasma cells. 
B)  B cells. 
C)  T helper cells. 
D)  cytotoxic T cells.

Question 9

Which cell is capable of producing antibody?

Accepted Answer

A)  Plasma cell 
B)  CD4+ T cell 
C)  Macrophage 
D)  Neutrophil 
A)  Plasma cell 
B)  CD4+ T cell 
C)  Macrophage 
D)  Neutrophil

Question 10

T helper cells recognize which of the following?

Accepted Answer

A)  Exogenous peptide bound to class II MHC 
B)  Native extracellular viral proteins 
C)  Endogenous peptides bound to class I MHC 
D)  Microbe-specific structures 
A)  Exogenous peptide bound to class II MHC 
B)  Native extracellular viral proteins 
C)  Endogenous peptides bound to class I MHC 
D)  Microbe-specific structures

Question 11

T lymphocytes undergo antigen-independent maturation in the:

Accepted Answer

A)  thymus. 
B)  bone marrow. 
C)  lymph node. 
D)  spleen. 
A)  thymus. 
B)  bone marrow. 
C)  lymph node. 
D)  spleen.

Question 12

Immunoglobulin gene rearrangements occur in which stage of B-cell development?

Accepted Answer

A)  Pro-B cell 
B)  Pre-B cell 
C)  Immature B cell 
D)  Mature B cell 
A)  Pro-B cell 
B)  Pre-B cell 
C)  Immature B cell 
D)  Mature B cell

Question 13

Identification of T-cell subsets is best accomplished with the use of:

Accepted Answer

A)  antigen-induced proliferation assays. 
B)  cytotoxicity assays. 
C)  flow cytometry. 
D)  serum electrophoresis. 
A)  antigen-induced proliferation assays. 
B)  cytotoxicity assays. 
C)  flow cytometry. 
D)  serum electrophoresis.

Question 14

T cells differ from B cells in which of the following ways?

Accepted Answer

A)  T cells express surface immunoglobulin. 
B)  B cells express CD19 but not CD3. 
C)  T cells express CD19, CD3, and CD4. 
D)  B cells express surface immunoglobulin and CD3. 
A)  T cells express surface immunoglobulin. 
B)  B cells express CD19 but not CD3. 
C)  T cells express CD19, CD3, and CD4. 
D)  B cells express surface immunoglobulin and CD3.

Question 15

Helper T cells that promote a humoral immune response include which of the following?

Accepted Answer

A)  Th1 
B)  Th2 
C)  Th17 
D)  All of the above 
A)  Th1 
B)  Th2 
C)  Th17 
D)  All of the above

Question 16

Predominant cell types involved in the humoral immune response are:

Accepted Answer

A)  eosinophils. 
B)  macrophages. 
C)  neutrophils. 
D)  B cells. 
A)  eosinophils. 
B)  macrophages. 
C)  neutrophils. 
D)  B cells.

Question 17

The T-cell receptor for antigen comprises which of the following molecules?

Accepted Answer

A)  Alpha and beta chains 
B)  Two gamma and two delta chains 
C)  Epsilon and gamma chains 
D)  Alpha chain and beta-2 microglobulin 
A)  Alpha and beta chains 
B)  Two gamma and two delta chains 
C)  Epsilon and gamma chains 
D)  Alpha chain and beta-2 microglobulin

Question 18

Which marker would be found on pre-B cells?

Accepted Answer

A)  CD3 
B)  Mu heavy chains 
C)  CD16 
D)  IgD 
A)  CD3 
B)  Mu heavy chains 
C)  CD16 
D)  IgD

Question 19

Antigen-independent differentiation of B cells occurs in the:

Accepted Answer

A)  bone marrow. 
B)  spleen. 
C)  lymph node. 
D)  Peyer's patches. 
A)  bone marrow. 
B)  spleen. 
C)  lymph node. 
D)  Peyer's patches.

Question 20

Cytotoxic T cells are the primary immune response against which type of pathogen?

Accepted Answer

A)  Viruses 
B)  Parasites 
C)  Bacteria 
D)  Fungi 
A)  Viruses 
B)  Parasites 
C)  Bacteria 
D)  Fungi

Exam 4: Adaptive Immunity

The purpose of negative selection of B cells is to:

A cell that can recall previous contact with a particular antigen so that subsequent exposure leads to a more rapid and more effective immune response than the first encounter is which type of cell?

Perforin and granzymes are used by which cells to kill target cells?

Which type of helper T cell promotes cytotoxic activity?

Which cells are responsible for killing virally infected host cells and tumor cells?

A critical receptor involved in the second signal for T-dependent B-cell activation is:

Which of the following cells that participate in cell-mediated immunity are antigen specific and directly cytotoxic for target cells?

The cells that primarily function by secreting large amounts of cytokines are:

Which cell is capable of producing antibody?

T helper cells recognize which of the following?

T lymphocytes undergo antigen-independent maturation in the:

Immunoglobulin gene rearrangements occur in which stage of B-cell development?

Identification of T-cell subsets is best accomplished with the use of:

T cells differ from B cells in which of the following ways?

Helper T cells that promote a humoral immune response include which of the following?

Predominant cell types involved in the humoral immune response are:

The T-cell receptor for antigen comprises which of the following molecules?

Which marker would be found on pre-B cells?

Antigen-independent differentiation of B cells occurs in the:

Cytotoxic T cells are the primary immune response against which type of pathogen?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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