Question 1

In Arabidopsis, the FLC gene is necessary to promote flower development.

Accepted Answer

A) True 
 B)False  False

Question 2

How many Barr bodies would an individual with a XXY genotype possess?

Accepted Answer

A)  0 
B)  1 
C)  2 
D)  None of the answers are correct 
A)  0 
B)  1 
C)  2 
D)  None of the answers are correct B

Question 3

After the paramutable allele is altered, its expression is the same or similar to the paramutagenic allele.

Accepted Answer

A) True 
 B)False  True

Question 4

The trimethylation of lysine 27 in histone H3(H3k27) causes the repression of the FLC gene.

Accepted Answer

A) True 
 B)False

Question 5

It is possible that the effects of the association of the ICR and DMR regions with the CTC factors could be distance dependent. An experimental outline could be devised where the effects of the distances of these regions could be varied and the rates of transcription could be measured. Below is a graph of some possible results. Which letter represents the most likely outcome if an increase in distance between these two regions results in a diminished effect on transcription rates.

Accepted Answer

A)  A 
B)  B 
C)  C 
D)  D 
A)  A 
B)  B 
C)  C 
D)  D

Question 6

The red1' allele is said to be paramutagenic, because it can change the expression of another allele.

Accepted Answer

A) True 
 B)False

Question 7

In cancer cells there is typically under expression of oncogenes

Accepted Answer

A) True 
 B)False

Question 8

What is the molecular mechanism for imprinting a gene?

Accepted Answer

A)  Acetylation 
B)  Nitration 
C)  Phosphorylation 
D)  Methylation 
A)  Acetylation 
B)  Nitration 
C)  Phosphorylation 
D)  Methylation

Question 9

Which of the following are molecular mechanisms used in epigenetic gene regulation?

Accepted Answer

A)  DNA methylation 
B)  Covalent histone modification 
C)  Chromatin remodeling 
D)  Answers A, B, and C are correct 
A)  DNA methylation 
B)  Covalent histone modification 
C)  Chromatin remodeling 
D)  Answers A, B, and C are correct

Question 10

Royal jelly feed to bee larvae causes hyperexpression of DNA methyltransferase

Accepted Answer

A) True 
 B)False

Question 11

Which of the following is an example of epigenetic inheritance

Accepted Answer

A)  Expression of the Igf-2 gene based on methylation of the ICR and DMR regions 
B)  Inheritance of flower color as studied by Mendel 
C)  Leaf coloration based on mitochondrial inheritance 
D)  Snail shell twist patterns 
A)  Expression of the Igf-2 gene based on methylation of the ICR and DMR regions 
B)  Inheritance of flower color as studied by Mendel 
C)  Leaf coloration based on mitochondrial inheritance 
D)  Snail shell twist patterns

Question 12

Lamarck is remembered for his theory of inheritance which hypothesized that physical characteristics acquired during an individuals lifetime were passed onto their offspring. How does this differ from epigenetic inheritance where the diet of the mother affects coat color of the offspring?

Accepted Answer

A)  There is no difference between Lamarckian theories of inheritance and epigenetic inheritance 
B)  Epigenetic changes occur on a specific gene. If the mother does not carry the gene, then coat color will not be affected by diet 
C)  The change in coat color occurs in the offspring and not in the mother 
D)  Answers B and C are correct 
A)  There is no difference between Lamarckian theories of inheritance and epigenetic inheritance 
B)  Epigenetic changes occur on a specific gene. If the mother does not carry the gene, then coat color will not be affected by diet 
C)  The change in coat color occurs in the offspring and not in the mother 
D)  Answers B and C are correct

Question 13

In paramutation, the DNA sequence is changed temporarily

Accepted Answer

A) True 
 B)False

Question 14

What genes appear to be controlled by the Xic?

Accepted Answer

A)  Xist and Tsix 
B)  Xist 
C)  TsiX 
D)  Xic 
A)  Xist and Tsix 
B)  Xist 
C)  TsiX 
D)  Xic

Question 15

If a cell is fused with another cell, which of the following would be the best example of a trans-mechanism of epigenetic control?

Accepted Answer

A)  A gene that is originally silenced in one cell but expressed in the other is silenced in the hybrid 
B)  A gene that is originally silenced in one cell but expressed in the other is still expressed in the hybrid. 
C)  The methylation pattern of the same gene from either cell is not altered 
D)  There are no examples that could conform to a trans-mechanism 
A)  A gene that is originally silenced in one cell but expressed in the other is silenced in the hybrid 
B)  A gene that is originally silenced in one cell but expressed in the other is still expressed in the hybrid. 
C)  The methylation pattern of the same gene from either cell is not altered 
D)  There are no examples that could conform to a trans-mechanism

Question 16

If a human cell has two Barr bodies then the genotype of the individual could be

Accepted Answer

A)  XXXY 
B)  XXXXY 
C)  XXY 
D)  XYY 
A)  XXXY 
B)  XXXXY 
C)  XXY 
D)  XYY

Question 17

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Accepted Answer

A)  TrxG proteins methylate lysine 27 on histone H3 while PcG complexes methylate lysine 4 on H3 
B)  Methylation of lysine at position 4 on H3 results in silencing of gene expression 
C)  TrxG complex proteins activate gene expression by methylating lysine 4 on H3, while PcG complex proteins repress gene expression by methylating lysine 27 on H3. 
D)  Methylation of H3 on lysine 27 can result in activation of transcription 
A)  TrxG proteins methylate lysine 27 on histone H3 while PcG complexes methylate lysine 4 on H3 
B)  Methylation of lysine at position 4 on H3 results in silencing of gene expression 
C)  TrxG complex proteins activate gene expression by methylating lysine 4 on H3, while PcG complex proteins repress gene expression by methylating lysine 27 on H3. 
D)  Methylation of H3 on lysine 27 can result in activation of transcription

Question 18

Most imprinted genes are silenced. What is one exception to this rule?

Accepted Answer

A)  H19 
B)  Igf-2 
C)  UBE3A 
D)  SNRPN 
A)  H19 
B)  Igf-2 
C)  UBE3A 
D)  SNRPN

Question 19

In maize red1' is a strongly expressed allele that is paramutable

Accepted Answer

A) True 
 B)False

Question 20

Which of the following is part of the process of X chromosome inactivation

Accepted Answer

A)  Expression of Xist from both chromosomes at the start of the process 
B)  Binding of multiple Xist transcripts to Xic on the X chromosome that will be inactivated 
C)  Compaction of the active X chromosome into a Barr body 
D)  Binding of Tsix transcripts to the X chromosome to be inactivated after the Xist transcripts binds to Xic 
A)  Expression of Xist from both chromosomes at the start of the process 
B)  Binding of multiple Xist transcripts to Xic on the X chromosome that will be inactivated 
C)  Compaction of the active X chromosome into a Barr body 
D)  Binding of Tsix transcripts to the X chromosome to be inactivated after the Xist transcripts binds to Xic

Exam 16: Gene Regulation in Eukaryotes Ii: Epigenetics

In Arabidopsis, the FLC gene is necessary to promote flower development.

How many Barr bodies would an individual with a XXY genotype possess?

After the paramutable allele is altered, its expression is the same or similar to the paramutagenic allele.

The trimethylation of lysine 27 in histone H3(H3k27) causes the repression of the FLC gene.

The red1' allele is said to be paramutagenic, because it can change the expression of another allele.

In cancer cells there is typically under expression of oncogenes

What is the molecular mechanism for imprinting a gene?

Which of the following are molecular mechanisms used in epigenetic gene regulation?

Royal jelly feed to bee larvae causes hyperexpression of DNA methyltransferase

Which of the following is an example of epigenetic inheritance

Lamarck is remembered for his theory of inheritance which hypothesized that physical characteristics acquired during an individuals lifetime were passed onto their offspring. How does this differ from epigenetic inheritance where the diet of the mother affects coat color of the offspring?

In paramutation, the DNA sequence is changed temporarily

What genes appear to be controlled by the Xic?

If a cell is fused with another cell, which of the following would be the best example of a trans-mechanism of epigenetic control?

If a human cell has two Barr bodies then the genotype of the individual could be

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Most imprinted genes are silenced. What is one exception to this rule?

In maize red1' is a strongly expressed allele that is paramutable

Which of the following is part of the process of X chromosome inactivation

Overview of Genetics

Mendelian Inheritance

Chromosome Transmission During Cell Division and Sexual Reproduction

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes I: Transcriptional and Translation Regulation

Non-Coding Rnas

Genetics of Viruses

Gene Mutation and Dna Repair

Recombination, Immunogenetics, and Transposition

Molecular Technologies

Biotechnology

Genomics I: Analysis of Dna

Genomics Ii: Functional Genomics, Proteomics, and Bioinformatics

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Complex and Quantitative Traits

Evolutionary Genetics

Filters