Question 1

Metagenomics refers to the molecular analysis of the entire genome of a species.

Accepted Answer

A) True 
 B)False  False

Question 2

To map a gene by chromosome walking, the sequence of the gene to be mapped is required.

Accepted Answer

A) True 
 B)False  False

Question 3

A ________ is a combination of a plasmid vector and phage λ.

Accepted Answer

A)  contig 
B)  artificial chromosome 
C)  cosmid 
D)  positional clone 
E)  transposable element 
A)  contig 
B)  artificial chromosome 
C)  cosmid 
D)  positional clone 
E)  transposable element C

Question 4

In a FISH procedure, the probe being used is labeled with a fluorescent tag.

Accepted Answer

A) True 
 B)False

Question 5

Which of the following acronyms describes a technique used in chromosome painting?

Accepted Answer

A)  RFLP 
B)  VNTR 
C)  STR 
D)  FISH 
E)  STS 
A)  RFLP 
B)  VNTR 
C)  STR 
D)  FISH 
E)  STS

Question 6

For this question, match each molecular marker with its correct description. Each answer is used only once.
A) RFLP
B) SNP
C) STR
D) STS
-Variations in the distance between restriction sites in individuals

Accepted Answer

The answer of For this question, match each molecular marker...

Question 7

________ uses the unique banding patterns of a chromosome to determine the general location of a gene.

Accepted Answer

A)  Physical mapping 
B)  Cytogenetic mapping 
C)  Linkage mapping 
A)  Physical mapping 
B)  Cytogenetic mapping 
C)  Linkage mapping

Question 8

In shotgun sequencing, how is a complete sequence of a genome reconstructed?

Accepted Answer

A)  The entire genome is directly sequenced chromosome by chromosome. 
B)  The genome is fragmented and sequences of each fragment are arranged so that overlapping regions are identified. 
C)  The sequences of a large number of individuals is obtained and "averaged" to obtain the complete sequence. 
D)  The position of each marker and gene are first mapped relative to regions for which the genomic sequence is not known. 
A)  The entire genome is directly sequenced chromosome by chromosome. 
B)  The genome is fragmented and sequences of each fragment are arranged so that overlapping regions are identified. 
C)  The sequences of a large number of individuals is obtained and "averaged" to obtain the complete sequence. 
D)  The position of each marker and gene are first mapped relative to regions for which the genomic sequence is not known.

Question 9

For this question, match each molecular marker with its correct description. Each answer is used only once.
A) RFLP
B) SNP
C) STR
D) STS
-A marker that is found at only one site within the genome

Accepted Answer

The answer of For this question, match each molecular marker...

Question 10

Which of the following samples would NOT be suitable for a metagenomics-based approach?

Accepted Answer

A)  Water samples from different bodies of water with different temperatures, salinities, and acidities 
B)  A soil sample from a farm where a new planting schedule has been implemented 
C)  A water sample from an industrial site that has been contaminated with pollutants 
D)  A fecal sample from a patient with irritable bowel syndrome 
E)  A homogeneous population of skin cancer cells collected from a patient biopsy 
A)  Water samples from different bodies of water with different temperatures, salinities, and acidities 
B)  A soil sample from a farm where a new planting schedule has been implemented 
C)  A water sample from an industrial site that has been contaminated with pollutants 
D)  A fecal sample from a patient with irritable bowel syndrome 
E)  A homogeneous population of skin cancer cells collected from a patient biopsy

Question 11

Match each type of chromosome mapping with the units used to measure the distance between loci.
A) Number of base pairs (bp)
B) Map units (mu)
C) Distance between bands
-Linkage mapping

Accepted Answer

The answer of Match each type of chromosome mapping with...

Question 12

A site that has variation within the members of the population is said to be ________.

Accepted Answer

A)  Monomorphic 
B)  Polymorphic 
C)  Trimorphic 
A)  Monomorphic 
B)  Polymorphic 
C)  Trimorphic

Question 13

The experimental process of determining the relative location of genes or other segments of DNA along individual chromosomes is called

Accepted Answer

A)  mapping. 
B)  metagenomics. 
C)  DNA sequencing. 
D)  proteomics. 
A)  mapping. 
B)  metagenomics. 
C)  DNA sequencing. 
D)  proteomics.

Question 14

BAC stands for bacterial artificial chromosome.

Accepted Answer

A) True 
 B)False

Question 15

What does physical mapping provide that the other types of genetic mapping do not?

Accepted Answer

A)  Recombination distances between genes 
B)  Number of nucleotide base-pairs between genes 
C)  Relationship of the gene to specific chromosomal banding patterns 
A)  Recombination distances between genes 
B)  Number of nucleotide base-pairs between genes 
C)  Relationship of the gene to specific chromosomal banding patterns

Question 16

An RFLP marker may be used to predict the likelihood that an individual carries a trait for a specific disease.

Accepted Answer

A) True 
 B)False

Question 17

The most common microsatellite in humans is ________.

Accepted Answer

A)  (AT)100 
B)  (C
A) n 
C)  (TG)n 
D)  (CAT)n 
A)  (AT)100 
B)  (C
A) n 
C)  (TG)n 
D)  (CAT)n

Question 18

Comparative genomics attempts to define evolutionary relationships.

Accepted Answer

A) True 
 B)False

Question 19

An amplified restriction fragment length polymorphism is a combination of the procedures for producing RFLP and STS markers.

Accepted Answer

A) True 
 B)False

Question 20

Match each type of chromosome mapping with the units used to measure the distance between loci.
A) Number of base pairs (bp)
B) Map units (mu)
C) Distance between bands
-Physical mapping

Accepted Answer

The answer of Match each type of chromosome mapping with...

Exam 23: Genomics I: Analysis of Dna

Metagenomics refers to the molecular analysis of the entire genome of a species.

To map a gene by chromosome walking, the sequence of the gene to be mapped is required.

A ________ is a combination of a plasmid vector and phage λ.

In a FISH procedure, the probe being used is labeled with a fluorescent tag.

Which of the following acronyms describes a technique used in chromosome painting?

For this question, match each molecular marker with its correct description. Each answer is used only once. A) RFLP B) SNP C) STR D) STS -Variations in the distance between restriction sites in individuals

________ uses the unique banding patterns of a chromosome to determine the general location of a gene.

In shotgun sequencing, how is a complete sequence of a genome reconstructed?

For this question, match each molecular marker with its correct description. Each answer is used only once. A) RFLP B) SNP C) STR D) STS -A marker that is found at only one site within the genome

Which of the following samples would NOT be suitable for a metagenomics-based approach?

Match each type of chromosome mapping with the units used to measure the distance between loci. A) Number of base pairs (bp) B) Map units (mu) C) Distance between bands -Linkage mapping

A site that has variation within the members of the population is said to be ________.

The experimental process of determining the relative location of genes or other segments of DNA along individual chromosomes is called

BAC stands for bacterial artificial chromosome.

What does physical mapping provide that the other types of genetic mapping do not?

An RFLP marker may be used to predict the likelihood that an individual carries a trait for a specific disease.

The most common microsatellite in humans is ________.

Comparative genomics attempts to define evolutionary relationships.

An amplified restriction fragment length polymorphism is a combination of the procedures for producing RFLP and STS markers.

Match each type of chromosome mapping with the units used to measure the distance between loci. A) Number of base pairs (bp) B) Map units (mu) C) Distance between bands -Physical mapping

Overview of Genetics

Mendelian Inheritance

Chromosome Transmission During Cell Division and Sexual Reproduction

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Gene Transcription and Rna Modification

Translation of Mrna

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes I: Transcriptional and Translation Regulation

Gene Regulation in Eukaryotes Ii: Epigenetics

Non-Coding Rnas

Genetics of Viruses

Gene Mutation and Dna Repair

Recombination, Immunogenetics, and Transposition

Molecular Technologies

Biotechnology

Genomics Ii: Functional Genomics, Proteomics, and Bioinformatics

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Complex and Quantitative Traits

Evolutionary Genetics

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