Question 1

Each of the following is involved in regulating mitotic Cdk activity except

Accepted Answer

A) cyclin synthesis and degradation. 
B) Cdk synthesis and degradation. 
C) Cdk phosphorylation. 
D) Cdk dephosphorylation. 
E) All are involved in regulating mitotic Cdk activity. 
A) cyclin synthesis and degradation. 
B) Cdk synthesis and degradation. 
C) Cdk phosphorylation. 
D) Cdk dephosphorylation. 
E) All are involved in regulating mitotic Cdk activity. B

Question 2

The appearance that the spindle and sister chromatids are inactive at metaphase is misleading because

Accepted Answer

A) the sister chromatids are completing replication at numerous replicons. 
B) the sister chromatids are signaling reformation of the nuclear envelope. 
C) each sister chromatid is assembling a kinetochore. 
D) each sister chromatid is being pulled toward its respective pole. 
E) the sister chromatids are decondensing. 
A) the sister chromatids are completing replication at numerous replicons. 
B) the sister chromatids are signaling reformation of the nuclear envelope. 
C) each sister chromatid is assembling a kinetochore. 
D) each sister chromatid is being pulled toward its respective pole. 
E) the sister chromatids are decondensing. D

Question 3

A population of T cells was stimulated to proliferate in response to a particular antigen.A sample of 1000 stimulated cells was analyzed by fluorescence-activated cell sorting (FACS)for total DNA content.Of the 1000 cells,400 had a 2n amount of DNA,200 had a 4n amount of DNA,and the remaining 400 cells had between a 2n and 4n amount of DNA.Additional immunofluorescence analysis revealed that 200 of the cells were in various stages of M phase and that M phase lasted 2 hours.What is the total length of the cell cycle?

Accepted Answer

A) 8 hours 
B) 12 hours 
C) 18 hours 
D) 20 hours 
E) 24 hours 
A) 8 hours 
B) 12 hours 
C) 18 hours 
D) 20 hours 
E) 24 hours D

Question 4

Which of the following is the correct order of the pathway by which activation of PI3-kinase stimulates cell division?

Accepted Answer

A) PIP3 formation-Akt phosphorylation-TOR activation-Rheb activation 
B) PIP3 formation-TOR activation-Rheb activation-Akt phosphorylation 
C) Akt phosphorylation-TOR activation-Rheb activation-PIP3 formation 
D) PIP3 formation-Akt phosphorylation-Rheb activation-TOR activation 
E) Akt phosphorylation-PIP3 formation-TOR activation-Rheb activation 
A) PIP3 formation-Akt phosphorylation-TOR activation-Rheb activation 
B) PIP3 formation-TOR activation-Rheb activation-Akt phosphorylation 
C) Akt phosphorylation-TOR activation-Rheb activation-PIP3 formation 
D) PIP3 formation-Akt phosphorylation-Rheb activation-TOR activation 
E) Akt phosphorylation-PIP3 formation-TOR activation-Rheb activation

Question 5

The epidermal growth factor-Ras signaling pathway stimulates increased expression of each of the following except

Accepted Answer

A) MAPK. 
B) Jun. 
C) Fos. 
D) Myc. 
E) The pathway turns on expression of all of the above. 
A) MAPK. 
B) Jun. 
C) Fos. 
D) Myc. 
E) The pathway turns on expression of all of the above.

Question 6

What type of protein is PTEN,which is mutated in 50% of prostate cancers?

Accepted Answer

A) kinase 
B) phosphatase 
C) growth factor receptor 
D) G protein 
E) ubiquitin ligase 
A) kinase 
B) phosphatase 
C) growth factor receptor 
D) G protein 
E) ubiquitin ligase

Question 7

When early G1 phase cells are fused with S-phase cells using polyethylene glycol (PEG),which of the following events would you expect to be induced?

Accepted Answer

A) cytokinesis in the S-phase cells 
B) condensation of chromosomes in the S-phase cells 
C) DNA replication in the G1 cells 
D) transition to G0 in the G1 cells 
E) spindle fiber formation in the G1 cells 
A) cytokinesis in the S-phase cells 
B) condensation of chromosomes in the S-phase cells 
C) DNA replication in the G1 cells 
D) transition to G0 in the G1 cells 
E) spindle fiber formation in the G1 cells

Question 8

As the most junior member of a lab,you are tasked with generating cell lines that accumulate DNA damage to investigate how random mutations affect transformation of cells into cancer cells.You decide to mutate proteins in the p53 pathway.Which three proteins would you mutate? Explain your reasoning.

Accepted Answer

p53-Destroying the activity of p53 block

Question 9

Raf is to MEK,as MEK is to

Accepted Answer

A) Ras. 
B) PI3K. 
C) MAPK. 
D) Cdk. 
E) Akt. 
A) Ras. 
B) PI3K. 
C) MAPK. 
D) Cdk. 
E) Akt.

Question 10

The generation time for a particular cell type is the time it takes a cell to

Accepted Answer

A) grow to twice its original size. 
B) replicate DNA during S phase. 
C) progress through M phase. 
D) progress through a complete cell cycle. 
E) transition from G0 to G1. 
A) grow to twice its original size. 
B) replicate DNA during S phase. 
C) progress through M phase. 
D) progress through a complete cell cycle. 
E) transition from G0 to G1.

Question 11

Each of the following is involved in plants cell cytokinesis except

Accepted Answer

A) phragmoplast alignment of Golgi-derived vesicles in the center of the dividing cell. 
B) fusion of Golgi-derived vesicles to form the cell plate. 
C) assembly of vesicle noncellulose components to form the primary cell wall. 
D) abscission of the cell into two cells. 
E) All are involved in plant cytokinesis. 
A) phragmoplast alignment of Golgi-derived vesicles in the center of the dividing cell. 
B) fusion of Golgi-derived vesicles to form the cell plate. 
C) assembly of vesicle noncellulose components to form the primary cell wall. 
D) abscission of the cell into two cells. 
E) All are involved in plant cytokinesis.

Question 12

Each of the following is true about anaphase except

Accepted Answer

A) anaphase is the shortest stage of the mitosis. 
B) during anaphase A,each chromosome is pulled to its respective pole as its kinetochore microtubules shorten. 
C) during anaphase B,the spindle poles are pushed further apart as interpolar microtubules lengthen. 
D) anaphase B may be coincident with or follow anaphase A,depending on the cell type. 
E) All of the above are true. 
A) anaphase is the shortest stage of the mitosis. 
B) during anaphase A,each chromosome is pulled to its respective pole as its kinetochore microtubules shorten. 
C) during anaphase B,the spindle poles are pushed further apart as interpolar microtubules lengthen. 
D) anaphase B may be coincident with or follow anaphase A,depending on the cell type. 
E) All of the above are true.

Question 13

Terminally differentiated cells such as neurons are in the phase of the cell cycle known as ________.

Accepted Answer

The answer of Terminally differentiated cells such as neurons are...

Question 14

DNA replication of linear chromosomes is initiated at multiple sites known as ________.

Accepted Answer

The answer of DNA replication of linear chromosomes is initiated...

Question 15

Mitotic Cdk phosphorylates DNA repair proteins to prevent joining of ________ during mitosis.

Accepted Answer

The answer of Mitotic Cdk phosphorylates DNA repair proteins to...

Question 16

M phase involves two overlapping events known as ________ and ________.

Accepted Answer

mitosis; c

Question 17

Which of the following occurs during prometaphase (late prophase)?

Accepted Answer

A) continuous kinetochore microtubule shortening 
B) Rho-stimulated formation of a contractile ring 
C) centrosome duplication 
D) APC targeting of securin destruction 
E) nuclear envelope fragmentation 
A) continuous kinetochore microtubule shortening 
B) Rho-stimulated formation of a contractile ring 
C) centrosome duplication 
D) APC targeting of securin destruction 
E) nuclear envelope fragmentation

Question 18

Cell growth is linked to the cell cycle by a protein kinase known as ________,so that cells can divide without getting progressively smaller.

Accepted Answer

TOR or tar

Question 19

Mitotic Cdk-cyclin is active when it is

Accepted Answer

A) singly phosphorylated. 
B) acetylated. 
C) doubly phosphorylated. 
D) doubly methylated. 
E) cleaved by proteases. 
A) singly phosphorylated. 
B) acetylated. 
C) doubly phosphorylated. 
D) doubly methylated. 
E) cleaved by proteases.

Question 20

Which of the following is eliminated in rapidly dividing embryonic cells that get smaller with each cell division?

Accepted Answer

A) G1 phase 
B) S phase 
C) G2 phase 
D) M-phase chromosome separation 
E) M-phase cytokinesis 
A) G1 phase 
B) S phase 
C) G2 phase 
D) M-phase chromosome separation 
E) M-phase cytokinesis

Exam 24: The Cell Cycle and Mitosis

Each of the following is involved in regulating mitotic Cdk activity except

The appearance that the spindle and sister chromatids are inactive at metaphase is misleading because

Which of the following is the correct order of the pathway by which activation of PI3-kinase stimulates cell division?

The epidermal growth factor-Ras signaling pathway stimulates increased expression of each of the following except

What type of protein is PTEN,which is mutated in 50% of prostate cancers?

When early G1 phase cells are fused with S-phase cells using polyethylene glycol (PEG),which of the following events would you expect to be induced?

Raf is to MEK,as MEK is to

The generation time for a particular cell type is the time it takes a cell to

Each of the following is involved in plants cell cytokinesis except

Each of the following is true about anaphase except

Terminally differentiated cells such as neurons are in the phase of the cell cycle known as ________.

DNA replication of linear chromosomes is initiated at multiple sites known as ________.

Mitotic Cdk phosphorylates DNA repair proteins to prevent joining of ________ during mitosis.

M phase involves two overlapping events known as ________ and ________.

Which of the following occurs during prometaphase (late prophase)?

Cell growth is linked to the cell cycle by a protein kinase known as ________,so that cells can divide without getting progressively smaller.

Mitotic Cdk-cyclin is active when it is

Which of the following is eliminated in rapidly dividing embryonic cells that get smaller with each cell division?

A Preview of Cell Biology

The Chemistry of the Cell

The Macromolecules of the Cell

Cells and Organelles

Bioenergetics: the Flow of Energy in the Cell

Enzymes: the Catalysts of Life

Membranes: Their Structure,function,and Chemistry

Transport Across Membranes: Overcoming the Permeability Barrier

Chemotrophic Energy Metabolism: Glycolysis and Fermentation

Chemotrophic Energy Metabolism: Aerobic Respiration

Phototrophic Energy Metabolism: Photosynthesis

The Endomembrane System

Cytoskeletal Systems

Cellular Movement: Motility and Contractility

Beyond the Cell: Cell Adhesions, cell Junctions, and Extracellular Structures

The Structural Basis of Cellular Information: Dna, chromosomes, and the Nucleus

DNA Replication, repair, and Recombination

Gene Expression: Ithe Genetic Code and Transcription

Gene Expression: Iiprotein Synthesis and Sorting

The Regulation of Gene Expression

Molecular Biology Techniques for Cell Biology

Signal Transduction Mechanisms: Ielectrical and Synaptic Signaling in Neurons

Signal Transduction Mechanisms: Iimessengers and Receptors

Sexual Reproduction,meiosis,and Genetic Recombination

Filters

M phase involves two overlapping events known as and .