Exam 13: Cytoskeletal Systems

Cancer is a disease in which cells exhibit uncontrolled cell division.Drugs used in the study of microtubules are also used in the treatment of cancer.Why are drugs that disrupt microtubules more useful in the treatment of cancer than are drugs used to disrupt microfilaments? What is the name of the category of these drugs that describes their function?

A microtubule-organizing center (MTOC)

Which of the following proteins is associated with the precise control of where microtubules depolymerize during mitosis?

Cancer cells retain the IF proteins from the tissue of origin even after metastasizing to other tissues.How is this important in the diagnosis and treatment of cancer?

Cytochalasins prevent addition of monomers to preexisting ________.

You have discovered a new cytoskeletal element and need to identify and characterize it for further work.How would you go about examining this protein to ultimately classify it as a cytoskeletal element?

What are some of the drugs used to study microtubules?

Explain how the discovery of cytoskeletal elements in prokaryotes contributed to the current understanding of the endosymbiont theory.

Microfilaments function in

The Mitchison and Kirschner ________ model of how microtubules transition between periods of growth and catastrophe proposes that ________ bound to β-tubulin subunits at a microtubule plus end stabilizes the end and promotes growth,but if the rate of hydrolysis to ________ exceeds the rate of tubulin addition,the end becomes unstable and loses subunits.

________ is a drug that blocks cell division by stabilizing microtubules; as a result,it is used in the treatment of ________.

CapZ

Intermediate filaments

Which of the following is true about the structure of the microtubule wall?

A unique feature of ________ is that they are tissue-specific.

A network of ________,a "fourth cytoskeleton" is involved in pinching off yeast daughter cells.

Actin filaments may form each of the following except

The ________ is a dense network of microfilaments just beneath the plasma membrane.

All of the following are components associated with bacterial cytoskeletons except

Which of the following microtubule-interacting proteins would you target to disrupt cell division in actively replicating tumor cells?