Question 1

Uptake of low-density lipoproteins (LDLs)occurs by

Accepted Answer

A) simple diffusion. 
B) phagocytosis. 
C) facilitated transport. 
D) receptor-mediated endocytosis. 
E) pinocytosis. 
A) simple diffusion. 
B) phagocytosis. 
C) facilitated transport. 
D) receptor-mediated endocytosis. 
E) pinocytosis. D

Question 2

The chronic use of the ________ class of drugs can increase liver detoxifying enzymes that decrease the effectiveness of antibiotics,anticoagulants,and steroids.

Accepted Answer

barbiturate

Question 3

The movement of proteins and lipids from the ER to their appropriate locations within a cell is known as ________.

Accepted Answer

endomembrane trafficking

Question 4

The low pH of lysosomes is established by

Accepted Answer

A) acid hydrolases. 
B) ATP-dependent proton pumps. 
C) β-glucuronidases. 
D) catalases. 
E) superoxide dismutases. 
A) acid hydrolases. 
B) ATP-dependent proton pumps. 
C) β-glucuronidases. 
D) catalases. 
E) superoxide dismutases.

Question 5

The vesicles that are anchored to the plasma membrane at a nerve cell presynaptic site are specialized for

Accepted Answer

A) constitutive secretion. 
B) regulated secretion. 
C) polarized secretion. 
D) lysosome secretion. 
E) endocytosis. 
A) constitutive secretion. 
B) regulated secretion. 
C) polarized secretion. 
D) lysosome secretion. 
E) endocytosis.

Question 6

When a membrane protein is radioactively labeled during synthesis and followed through the various organelles in the secretory pathway,all the radioactivity is concentrated in the cis-Golgi apparatus six hours after the protein synthesis.This suggests that the protein

Accepted Answer

A) was imported directly into the cis-Golgi posttranslationally. 
B) contains a KDEL sequence near its C-terminus. 
C) has a membrane-spanning domain length equals the thickness of the cis-Golgi membrane. 
D) has a mannose-6-phosphate tag. 
E) is misfolded and being degraded in the cis-Golgi. 
A) was imported directly into the cis-Golgi posttranslationally. 
B) contains a KDEL sequence near its C-terminus. 
C) has a membrane-spanning domain length equals the thickness of the cis-Golgi membrane. 
D) has a mannose-6-phosphate tag. 
E) is misfolded and being degraded in the cis-Golgi.

Question 7

Which of the following is associated with extracellular digestion caused by release of the lysosomes enzymes into the environment?

Accepted Answer

A) Tay-Sachs disease 
B) rheumatoid arthritis 
C) autophagy 
D) Hunter syndrome 
E) Hurler syndrome 
A) Tay-Sachs disease 
B) rheumatoid arthritis 
C) autophagy 
D) Hunter syndrome 
E) Hurler syndrome

Question 8

Each of the following is a component involved in the SNARE hypothesis model mechanism except

Accepted Answer

A) v-SNARE. 
B) Rab GTPase. 
C) tethering complex. 
D) NSF protein. 
E) All are involved. 
A) v-SNARE. 
B) Rab GTPase. 
C) tethering complex. 
D) NSF protein. 
E) All are involved.

Question 9

________ is the triskelion molecule that forms the coats on vesicles associated with receptor-mediated endocytosis.

Accepted Answer

The answer of ________ is the triskelion molecule that forms...

Question 10

The ________ is the organelle involved in the post-translational modification of proteins and sorting of proteins to various intracellular and secretory compartments.

Accepted Answer

The answer of The ________ is the organelle involved in...

Question 11

Describe how low concentrations of Botox can be used as a treatment for wrinkles and muscle spasms.

Accepted Answer

Botulinum toxin (Botox)proteolyzes the S

Question 12

Which of the following cellular processes may be inhibited in tumor cells?

Accepted Answer

A) autophagy 
B) N-linked glycosylation 
C) caveolae uptake 
D) LDL degradation 
E) catalase activity 
A) autophagy 
B) N-linked glycosylation 
C) caveolae uptake 
D) LDL degradation 
E) catalase activity

Question 13

Explain the mechanism by which the fungal toxin brefeldin A affects retrieval of KDEL-tagged proteins from the cis-Golgi network back to the endoplasmic reticulum.

Accepted Answer

KDEL-tagged proteins are bound by recept

Question 14

In receptor-mediated endocytosis,each of the following is a fate for the receptors and/or vesicle contents except

Accepted Answer

A) transcytosis. 
B) digestion in a lysosome. 
C) recycling to the plasma membrane. 
D) release from the vesicle into the nucleus. 
E) All are possible fates. 
A) transcytosis. 
B) digestion in a lysosome. 
C) recycling to the plasma membrane. 
D) release from the vesicle into the nucleus. 
E) All are possible fates.

Question 15

Which of the following cell types would be associated with the greatest concentration of low-density lipoproteins (LDLs)?

Accepted Answer

A) skin 
B) muscle 
C) connective tissue 
D) blood 
E) liver 
A) skin 
B) muscle 
C) connective tissue 
D) blood 
E) liver

Question 16

In which of the following organelles would you expect to first find a protein destined to be secreted from a cell?

Accepted Answer

A) endosome 
B) Golgi apparatus 
C) lysosome 
D) secretory vesicle 
E) endoplasmic reticulum 
A) endosome 
B) Golgi apparatus 
C) lysosome 
D) secretory vesicle 
E) endoplasmic reticulum

Question 17

Each of the following is true about botulinum toxin (Botox)except

Accepted Answer

A) The toxin is one of the most potent toxins known. 
B) Botox is a SNARE protein. 
C) It can be used therapeutically to stop muscle spasms. 
D) It has been used to remove wrinkles caused by muscle contractions. 
E) It has potential use as a migraine headache treatment. 
A) The toxin is one of the most potent toxins known. 
B) Botox is a SNARE protein. 
C) It can be used therapeutically to stop muscle spasms. 
D) It has been used to remove wrinkles caused by muscle contractions. 
E) It has potential use as a migraine headache treatment.

Question 18

Which of the following organelles has the ability to catabolize alkanes found in oil and petroleum products?

Accepted Answer

A) mitochondria 
B) smooth endoplasmic reticulum 
C) peroxisomes 
D) lysosomes 
E) late endosomes 
A) mitochondria 
B) smooth endoplasmic reticulum 
C) peroxisomes 
D) lysosomes 
E) late endosomes

Question 19

Total internal reflection (TIRF)microscopy is best used to visualize fluorescently labeled protein activity

Accepted Answer

A) that is too small to see with regular light microscopy. 
B) on the upper surface of a cell. 
C) in the Golgi. 
D) on the lower surface of a cell. 
E) in the nucleus. 
A) that is too small to see with regular light microscopy. 
B) on the upper surface of a cell. 
C) in the Golgi. 
D) on the lower surface of a cell. 
E) in the nucleus.

Question 20

If you presented two substances-(1)LDL particles and (2)large aggregates of 'foreign' macromolecules-to a mixture of cells,which uptake mechanism would you expect the cells to use to ingest each substance? What distinguishes the uptake mechanisms?

Accepted Answer

(1)LDL: Cells with LDL receptors would u

Exam 12: The Endomembrane System

Uptake of low-density lipoproteins (LDLs)occurs by

The chronic use of the ________ class of drugs can increase liver detoxifying enzymes that decrease the effectiveness of antibiotics,anticoagulants,and steroids.

The movement of proteins and lipids from the ER to their appropriate locations within a cell is known as ________.

The low pH of lysosomes is established by

The vesicles that are anchored to the plasma membrane at a nerve cell presynaptic site are specialized for

When a membrane protein is radioactively labeled during synthesis and followed through the various organelles in the secretory pathway,all the radioactivity is concentrated in the cis-Golgi apparatus six hours after the protein synthesis.This suggests that the protein

Which of the following is associated with extracellular digestion caused by release of the lysosomes enzymes into the environment?

Each of the following is a component involved in the SNARE hypothesis model mechanism except

________ is the triskelion molecule that forms the coats on vesicles associated with receptor-mediated endocytosis.

The ________ is the organelle involved in the post-translational modification of proteins and sorting of proteins to various intracellular and secretory compartments.

Describe how low concentrations of Botox can be used as a treatment for wrinkles and muscle spasms.

Which of the following cellular processes may be inhibited in tumor cells?

Explain the mechanism by which the fungal toxin brefeldin A affects retrieval of KDEL-tagged proteins from the cis-Golgi network back to the endoplasmic reticulum.

In receptor-mediated endocytosis,each of the following is a fate for the receptors and/or vesicle contents except

Which of the following cell types would be associated with the greatest concentration of low-density lipoproteins (LDLs)?

In which of the following organelles would you expect to first find a protein destined to be secreted from a cell?

Each of the following is true about botulinum toxin (Botox)except

Which of the following organelles has the ability to catabolize alkanes found in oil and petroleum products?

Total internal reflection (TIRF)microscopy is best used to visualize fluorescently labeled protein activity

If you presented two substances-(1)LDL particles and (2)large aggregates of 'foreign' macromolecules-to a mixture of cells,which uptake mechanism would you expect the cells to use to ingest each substance? What distinguishes the uptake mechanisms?

A Preview of Cell Biology

The Chemistry of the Cell

The Macromolecules of the Cell

Cells and Organelles

Bioenergetics: the Flow of Energy in the Cell

Enzymes: the Catalysts of Life

Membranes: Their Structure,function,and Chemistry

Transport Across Membranes: Overcoming the Permeability Barrier

Chemotrophic Energy Metabolism: Glycolysis and Fermentation

Chemotrophic Energy Metabolism: Aerobic Respiration

Phototrophic Energy Metabolism: Photosynthesis

Cytoskeletal Systems

Cellular Movement: Motility and Contractility

Beyond the Cell: Cell Adhesions, cell Junctions, and Extracellular Structures

The Structural Basis of Cellular Information: Dna, chromosomes, and the Nucleus

DNA Replication, repair, and Recombination

Gene Expression: Ithe Genetic Code and Transcription

Gene Expression: Iiprotein Synthesis and Sorting

The Regulation of Gene Expression

Molecular Biology Techniques for Cell Biology

Signal Transduction Mechanisms: Ielectrical and Synaptic Signaling in Neurons

Signal Transduction Mechanisms: Iimessengers and Receptors

The Cell Cycle and Mitosis

Sexual Reproduction,meiosis,and Genetic Recombination

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