Exam 12: Gene Structure Expression, and Mutation

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Individuals with the genetic condition sickle cell anemia have hemoglobin coded with the gene that codes for valine instead of glutamic acid. What kind of mutation does this condition result from?

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Describe how exon shuffling could lead to the formation of novel proteins.

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Exon-intron junctions often fall at points that divide major functional regions, or domains, in encoded proteins. Genetic duplications and rearrangements can occasionally cut and paste parts of different genes together. When the cutting and pasting happens within introns, this brings together novel combinations of exons that will produce a new protein. The individual domains generally retain their specific functionality in the new protein. This mechanism can produce changes more quickly and more efficiently than random point mutations that affect only individual amino acids in a protein.

For each item or event, indicate the process it is associated with. -intron

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In which part of the ribosome is the growing polypeptide chain positioned during translation?

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Briefly describe the places where tRNA would be found in a ribosome and what its function is at each place.

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For each item or event, indicate the process it is associated with. -RNA-DNA double helix

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Why do smooth muscle and skeletal muscle have distinct mRNA forms?

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Transcription Diagram Transcription Diagram   -In the transcription diagram, what is the name of item B? -In the transcription diagram, what is the name of item B?

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What is the function of the 3' poly-A sequence in eukaryotic mRNA?

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Which enzyme catalyzes the joining of amino acids during translation?

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In the expression of the gene for insulin, which is secreted outside certain mammalian cells, which of the following steps will occur last?

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Which of the following processes best explains the diversity of human á-tropomyosin proteins?

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Describe the process of transcription in prokaryotes.

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Which enzyme performs the DNA unwinding function during transcription elongation?

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Suppose that two bases are inserted into the coding region of a gene just after the start codon of a gene. What type of mutation has occurred?

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Figure 12-1 Figure 12-1   -What does the structure in Figure 12-1 represent? -What does the structure in Figure 12-1 represent?

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Suppose that a DNA change results in the substitution of one codon for another, and the new codon specifies a different amino acid from the original. What type of mutation has occurred?

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Which molecule provides the energy that the cell requires for protein translation?

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Which sentence describes the routing of proteins to their final destinations in eukaryotic cells?

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How does the "Central Dogma" describe the flow of information of gene expression?

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