Question 1

Which is not an example of a induced mutational mechanism?

Accepted Answer

A) DNA replication errors 
B) Tautomeric shifts of nucleic acid bases 
C) Aberrant recombination 
D) UV light 
E) Transposable elements 
A) DNA replication errors 
B) Tautomeric shifts of nucleic acid bases 
C) Aberrant recombination 
D) UV light 
E) Transposable elements D

Question 2

How does position effect influence gene expression?

Accepted Answer

A)  Point mutations in promoters frequently occur by this mechanism 
B)  Translocations may result in a promoter that is normally used for one gene now controlling an entirely different gene. 
C)  Since this mechanism relies on recombination it relies on the positioning of one allele so that it is under the control of the other allele. 
D)  Translocations always result in a gene being recombined into an area of heterochromatin. 
A)  Point mutations in promoters frequently occur by this mechanism 
B)  Translocations may result in a promoter that is normally used for one gene now controlling an entirely different gene. 
C)  Since this mechanism relies on recombination it relies on the positioning of one allele so that it is under the control of the other allele. 
D)  Translocations always result in a gene being recombined into an area of heterochromatin. B

Question 3

A heritable change in the genetic material is called a mutation.

Accepted Answer

A) True 
 B)False  True

Question 4

TNRE repeats frequently result in the addition of extra histidine amino acids to the protein.

Accepted Answer

A) True 
 B)False

Question 5

The conversion of cytosine to uracil in DNA is an example of _____.

Accepted Answer

A) Depurination 
B) Tautomeric shifts 
C) Deamination 
D) Demethylation 
A) Depurination 
B) Tautomeric shifts 
C) Deamination 
D) Demethylation

Question 6

The most common genotype in a population is called the mutant genotype.

Accepted Answer

A) True 
 B)False

Question 7

Spontaneous mutations include

Accepted Answer

A) Depurination, deamination, errors in DNA replication 
B) UV light, radiation, deamination, depurination 
C) UV light, radiation, deamination, errors in replication 
D) UV light, errors in DNA replication, deamination, depurination 
A) Depurination, deamination, errors in DNA replication 
B) UV light, radiation, deamination, depurination 
C) UV light, radiation, deamination, errors in replication 
D) UV light, errors in DNA replication, deamination, depurination

Question 8

An example of a suppressor mutation would be

Accepted Answer

A) An intragenic mutation that restores the inactive protein's structure 
B) An intergenic mutation that increases the activity of a protein performing a different function as the mutated protein 
C) An intergenic mutation that activates a transcription factor that increases the espression of a normal protein 
D) A mutation that suppresses cell growth 
A) An intragenic mutation that restores the inactive protein's structure 
B) An intergenic mutation that increases the activity of a protein performing a different function as the mutated protein 
C) An intergenic mutation that activates a transcription factor that increases the espression of a normal protein 
D) A mutation that suppresses cell growth

Question 9

A mutation in a promoter region that causes the promoter sequence to more closely resemble the consensus sequence is called an up promoter mutation and results in a decrease in transcription.

Accepted Answer

A) True 
 B)False

Question 10

HRR usually uses a sister chromatid.

Accepted Answer

A) True 
 B)False

Question 11

An example of a base analog would be

Accepted Answer

A) EMS 
B) Nitrous acid 
C) 5BU 
D) Nitrogen mustards 
E) Acridine dyes 
A) EMS 
B) Nitrous acid 
C) 5BU 
D) Nitrogen mustards 
E) Acridine dyes

Question 12

Which types of mutations are least likely to be subjected to natural selection?

Accepted Answer

A) Silent 
B) Missense 
C) Nonsense 
D) Insertion 
A) Silent 
B) Missense 
C) Nonsense 
D) Insertion

Question 13

A sample of water is tested for mutagens. The water is subjected to a process known as high pressure liquid chromatography which can separate compounds based on their different biochemical properties. As material leaves the HPLC column its absorbance is measured at UV light which is used to detect a variety of different compounds. These readings were recorded as a trace on a graph (top chart in the figure). Fractions from the column are collected and then tested in an Ames assay (bottom chart in the figure). In this assay there were 900 colonies with the solvent alone control. Which fractions contain mutagens?

Accepted Answer

A)  7 and 16 
B)  3 and 10 
C)  3, 7, 10, and 16 
D)  None of these fractions appear to contain a mutagen 
A)  7 and 16 
B)  3 and 10 
C)  3, 7, 10, and 16 
D)  None of these fractions appear to contain a mutagen

Question 14

Silent mutations are possible due to the degenerate nature of the genetic code.

Accepted Answer

A) True 
 B)False

Question 15

Which repair mechanism utilizes MutL, MutH, and MutS proteins in

Accepted Answer

A) Recombinational repair 
B) Direct repair 
C) Base excision repair 
D) Mismatch repair 
E) Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A) Recombinational repair 
B) Direct repair 
C) Base excision repair 
D) Mismatch repair 
E) Nucleotide excision repair
F) Nonhomologous end joining (NHEJ)

Question 16

A temporary change in the conformation of a nitrogenous base is called ______.

Accepted Answer

A) Depurination 
B) A tautomeric shift 
C) Deamination 
D) None of the answers are correct 
A) Depurination 
B) A tautomeric shift 
C) Deamination 
D) None of the answers are correct

Question 17

A translocation that moves a gene from an area of euchromatin to heterochromatin would typically cause a(n) _______ in the expression of the gene.

Accepted Answer

A) Reduction 
B) Increase 
C) Gene expression would remain the same 
A) Reduction 
B) Increase 
C) Gene expression would remain the same

Question 18

Breakpoints in chromosome can lead to mutant phenotypes when they occur in the middle of a gene.

Accepted Answer

A) True 
 B)False

Question 19

A change in the chromosome number is called a point mutation.

Accepted Answer

A) True 
 B)False

Question 20

Mutations that change the configuration of a protein at a specific temperature are called ____ mutations.

Accepted Answer

A) Neutral 
B) Beneficial 
C) Deleterious 
D) Conditional 
A) Neutral 
B) Beneficial 
C) Deleterious 
D) Conditional

Exam 18: Gene Mutation and Dna Repair

Which is not an example of a induced mutational mechanism?

How does position effect influence gene expression?

A heritable change in the genetic material is called a mutation.

TNRE repeats frequently result in the addition of extra histidine amino acids to the protein.

The conversion of cytosine to uracil in DNA is an example of _____.

The most common genotype in a population is called the mutant genotype.

Spontaneous mutations include

An example of a suppressor mutation would be

A mutation in a promoter region that causes the promoter sequence to more closely resemble the consensus sequence is called an up promoter mutation and results in a decrease in transcription.

HRR usually uses a sister chromatid.

An example of a base analog would be

Which types of mutations are least likely to be subjected to natural selection?

Silent mutations are possible due to the degenerate nature of the genetic code.

Which repair mechanism utilizes MutL, MutH, and MutS proteins in

A temporary change in the conformation of a nitrogenous base is called ______.

A translocation that moves a gene from an area of euchromatin to heterochromatin would typically cause a(n) _______ in the expression of the gene.

Breakpoints in chromosome can lead to mutant phenotypes when they occur in the middle of a gene.

A change in the chromosome number is called a point mutation.

Mutations that change the configuration of a protein at a specific temperature are called ____ mutations.

Overview of Genetics

Mendelian Inheritance

Chromosome Transmission During Cell Division and Sexual Reproduction

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and Bacteriophages

Variation in Chromosome Structure and Number

Molecular Structure of DNA and RNA

Chromosome Organization and Molecular Structure

DNA Replication

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes I: Transcriptional Regulation

Gene Regulation in Eukaryotes II: Epigenetics and Regulation at the RNA Level

Genetics of Viruses

Recombination and Transposition at the Molecular Level

DNA Technologies

Biotechnology

Genomics I: Analysis of DNA

Genomics II: Functional Genomics, Proteomics, and Bioinformatics

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

Filters