Question 1

An individual that is a genetic mosaic would be the result of a germ cell mutation.

Accepted Answer

A) True 
 B)False

Question 2

Somatic cells are those that give rise to sperm and egg cells.

Accepted Answer

A) True 
 B)False

Question 3

What would be a set of anticipated results from a "Lederberg" experiment?

Accepted Answer

A)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 150 
B)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 1500 
C)  Total number of colonies on a plate: 500 Total number of resistant colonies on replica plate with T1: 1500 
D)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 0 
A)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 150 
B)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 1500 
C)  Total number of colonies on a plate: 500 Total number of resistant colonies on replica plate with T1: 1500 
D)  Total number of colonies on a plate: 1500 Total number of resistant colonies on replica plate with T1: 0

Question 4

Translocations and inversions may result in

Accepted Answer

A) TNRE 
B) Anticipation 
C) Position effect 
D) Genome mutations 
A) TNRE 
B) Anticipation 
C) Position effect 
D) Genome mutations

Question 5

The mutation frequency would be the same for all genes in a given culture.

Accepted Answer

A) True 
 B)False

Question 6

The Ames test may be used to determine if an agent is a mutagen.

Accepted Answer

A) True 
 B)False

Question 7

Which DNA repair mechanism uses DNA-N-glycolases?

Accepted Answer

A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Direct repair 
C)  Base excision repair 
D)  Mismatch repair 
E)  Nucleotide excision repair
F) Nonhomologous end joining (NHEJ)

Question 8

A mutagen is

Accepted Answer

A) an agent that can alter the structure of DNA and cause mutations. 
B) a depurinated base. 
C) a DNA polymerase without a 5' to 3' exonuclease. 
D) a deaminated base. 
A) an agent that can alter the structure of DNA and cause mutations. 
B) a depurinated base. 
C) a DNA polymerase without a 5' to 3' exonuclease. 
D) a deaminated base.

Question 9

The difference between the polymerases used in translesion syntheis repair and general DAN replication is

Accepted Answer

A)  The polymerase used in translesion synthesis has a pocket that can accommodate the lesions while DNA pol III's pocket cannot 
B)  There is no real difference between the polymerases except that the translesional polymerase is not part of the replication complex 
C)  The polymerase used in translesion synthesis has a pocket that cannot accommodate the lesions, that is part of the mechanism by which the lesions are removed. 
D)  The polymerase used to remove the lesion has a mdofied nucleotide binding pocket allowing for mispairing of nucleotides. 
A)  The polymerase used in translesion synthesis has a pocket that can accommodate the lesions while DNA pol III's pocket cannot 
B)  There is no real difference between the polymerases except that the translesional polymerase is not part of the replication complex 
C)  The polymerase used in translesion synthesis has a pocket that cannot accommodate the lesions, that is part of the mechanism by which the lesions are removed. 
D)  The polymerase used to remove the lesion has a mdofied nucleotide binding pocket allowing for mispairing of nucleotides.

Question 10

A mutation in one gene that compensates for a mutation in another gene to result in the wild-type phenotype is called an intergenic suppressor mutation.

Accepted Answer

A) True 
 B)False

Question 11

Evolution is the result of selecting only those mutations that result in an increased reproductive success.

Accepted Answer

A) True 
 B)False

Question 12

Beechdrops is a parasitic plant that cannot perform photosynthesis but relies on its host the Beech tree. However, Beechdrops still retains many if not all of the genes for photosynthesis. Snapdragons and gladiolas are common garden flowers that rely on their ability to perform photosynthesis. If you were to compare the gene sequences for these three plants for ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) a protein necessary for photosynthesis what would you predict?

Accepted Answer

A)  The differences between gladiolas and snapdragons would most likely be silent mutations while those in beechdrops may be silent or missense 
B)  Since these three plants are not highly related the sequences for RuBisCO would be very different between them 
C)  The differences between gladiolas and snapdragons would most likely be in the second nucleotide of codons while beechdrops would have a higher number of mutations in the third nucleotide of the diffferent codons 
D)  The differences between gladiolas and snapdragons would most likely be missense mutations while those in beechdrops may be silent or missense 
A)  The differences between gladiolas and snapdragons would most likely be silent mutations while those in beechdrops may be silent or missense 
B)  Since these three plants are not highly related the sequences for RuBisCO would be very different between them 
C)  The differences between gladiolas and snapdragons would most likely be in the second nucleotide of codons while beechdrops would have a higher number of mutations in the third nucleotide of the diffferent codons 
D)  The differences between gladiolas and snapdragons would most likely be missense mutations while those in beechdrops may be silent or missense

Question 13

The process of replica plating was designed to test if mutations occurred in response to a selective agent or if mutations were naturally present in the population before selection.

Accepted Answer

A) True 
 B)False

Question 14

Select the correct satement regarding the rate of mutation?

Accepted Answer

A) Rates of mutation per cell generation typically range from 10-5 to 10-9 
B) Mutation rates are consistent across species 
C) Mutation rates are not influenced by environmental conditions 
D) Mutation rates are constant 
A) Rates of mutation per cell generation typically range from 10-5 to 10-9 
B) Mutation rates are consistent across species 
C) Mutation rates are not influenced by environmental conditions 
D) Mutation rates are constant

Question 15

What is the difference between a forward and reverse mutation?

Accepted Answer

A)  A forward mutation is beneficial to the organism, while a reverse mutation is harmful to the organism. 
B)  A forward mutation changes the genotype to the wild-type genotype, while a reverse mutation changes the genotype to a mutant genotype. 
C)  A forward mutation changes the wild-type genotype to some new genetic combination, while a reverse mutation changes a genotype to the wild-type genotype. 
D)  None of the answers are correct 
A)  A forward mutation is beneficial to the organism, while a reverse mutation is harmful to the organism. 
B)  A forward mutation changes the genotype to the wild-type genotype, while a reverse mutation changes the genotype to a mutant genotype. 
C)  A forward mutation changes the wild-type genotype to some new genetic combination, while a reverse mutation changes a genotype to the wild-type genotype. 
D)  None of the answers are correct

Question 16

The term polarity is associated with mutations in eukaryotic cells.

Accepted Answer

A) True 
 B)False

Question 17

Which repair mechanism is responsible for repairing damage from UV radiation?

Accepted Answer

A)  Recombinational repair 
B)  Base excision repair 
C)  Mismatch repair 
D)  Nucleotide excision repair 
E)  Nonhomologous end joining (NHEJ) 
A)  Recombinational repair 
B)  Base excision repair 
C)  Mismatch repair 
D)  Nucleotide excision repair 
E)  Nonhomologous end joining (NHEJ)

Question 18

A culture of

Accepted Answer

A)  Physiological adaptation theory 
B)  Random mutation theory 
C)  Both theories 
D)  Neither theory 
E) coli bacteria is used to establish several subcultures.Each subculture is then plated and individulal colonies that grow on the agar plates are then tested for their sensitivity to the bacteriophage T1. There is a spectrum of sensitivities where some plates have a high number of resistant colonies and some plates had very few. This data supports which theory? 
A)  Physiological adaptation theory 
B)  Random mutation theory 
C)  Both theories 
D)  Neither theory 
E) coli bacteria is used to establish several subcultures.Each subculture is then plated and individulal colonies that grow on the agar plates are then tested for their sensitivity to the bacteriophage T1. There is a spectrum of sensitivities where some plates have a high number of resistant colonies and some plates had very few. This data supports which theory?

Question 19

Darwin's theory of natural selection supported the physical adaptation theory.

Accepted Answer

A) True 
 B)False

Question 20

Ethyl methanesulfonate (EMS) is an example of a deaminating agent.

Accepted Answer

A) True 
 B)False

Exam 18: Gene Mutation and Dna Repair

An individual that is a genetic mosaic would be the result of a germ cell mutation.

Somatic cells are those that give rise to sperm and egg cells.

What would be a set of anticipated results from a "Lederberg" experiment?

Translocations and inversions may result in

The mutation frequency would be the same for all genes in a given culture.

The Ames test may be used to determine if an agent is a mutagen.

Which DNA repair mechanism uses DNA-N-glycolases?

A mutagen is

The difference between the polymerases used in translesion syntheis repair and general DAN replication is

A mutation in one gene that compensates for a mutation in another gene to result in the wild-type phenotype is called an intergenic suppressor mutation.

Evolution is the result of selecting only those mutations that result in an increased reproductive success.

The process of replica plating was designed to test if mutations occurred in response to a selective agent or if mutations were naturally present in the population before selection.

Select the correct satement regarding the rate of mutation?

What is the difference between a forward and reverse mutation?

The term polarity is associated with mutations in eukaryotic cells.

Which repair mechanism is responsible for repairing damage from UV radiation?

A culture of

Darwin's theory of natural selection supported the physical adaptation theory.

Ethyl methanesulfonate (EMS) is an example of a deaminating agent.

Overview of Genetics

Mendelian Inheritance

Chromosome Transmission During Cell Division and Sexual Reproduction

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria and Bacteriophages

Variation in Chromosome Structure and Number

Molecular Structure of DNA and RNA

Chromosome Organization and Molecular Structure

DNA Replication

Gene Transcription and RNA Modification

Translation of MRNA

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes I: Transcriptional Regulation

Gene Regulation in Eukaryotes II: Epigenetics and Regulation at the RNA Level

Genetics of Viruses

Recombination and Transposition at the Molecular Level

DNA Technologies

Biotechnology

Genomics I: Analysis of DNA

Genomics II: Functional Genomics, Proteomics, and Bioinformatics

Medical Genetics and Cancer

Developmental Genetics

Population Genetics

Quantitative Genetics

Evolutionary Genetics

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