Question 1

A lymphocyte exhibits the following markers: CD19,IgM,IgD.What is its likely identity?

Accepted Answer

A)  Double-negative T cell 
B)  Immature B cell 
C)  Double-positive T cell 
D)  Mature B cell 
A)  Double-negative T cell 
B)  Immature B cell 
C)  Double-positive T cell 
D)  Mature B cell

Question 2

Which T-cell surface protein is associated with the T-cell receptor and is involved in signal transduction?

Accepted Answer

A)  CD3 
B)  CD4 
C)  CD8 
D)  CD154 
A)  CD3 
B)  CD4 
C)  CD8 
D)  CD154

Question 3

The function of CD4+ T cells is:

Accepted Answer

A)  to help B cells make antibody. 
B)  to kill virally infected cells. 
C)  phagocytosis. 
D)  production of opsonins. 
A)  to help B cells make antibody. 
B)  to kill virally infected cells. 
C)  phagocytosis. 
D)  production of opsonins.

Question 4

Which marker is found on the group of T cells that assists B cells in making antibody?

Accepted Answer

A)  CD2 
B)  CD19 
C)  CD4 
D)  CD5 
A)  CD2 
B)  CD19 
C)  CD4 
D)  CD5

Question 5

The receptor for antigen on a mature naïve B cell is:

Accepted Answer

A)  class I MHC. 
B)  class II MHC. 
C)  IgG. 
D)  IgM. 
A)  class I MHC. 
B)  class II MHC. 
C)  IgG. 
D)  IgM.

Question 6

A T-independent antibody response:

Accepted Answer

A)  involves memory cells. 
B)  results in the secretion of primarily IgM. 
C)  is usually triggered by haptens. 
D)  requires antigen binding to surface IgD. 
A)  involves memory cells. 
B)  results in the secretion of primarily IgM. 
C)  is usually triggered by haptens. 
D)  requires antigen binding to surface IgD.

Question 7

T cells that respond against self-antigens are inactivated by:

Accepted Answer

A)  binding to immunoglobulin. 
B)  intermediate-strength binding to self MHC. 
C)  apoptosis. 
D)  positive selection. 
A)  binding to immunoglobulin. 
B)  intermediate-strength binding to self MHC. 
C)  apoptosis. 
D)  positive selection.

Question 8

Which statement best describes the specific antigen receptor that is a part of CD3 found on T cells?

Accepted Answer

A)  It appears in the double-negative stage. 
B)  Alpha and beta chains bind antigen. 
C)  It is found only on T helper cells. 
D)  All eight chains are specific for antigen. 
A)  It appears in the double-negative stage. 
B)  Alpha and beta chains bind antigen. 
C)  It is found only on T helper cells. 
D)  All eight chains are specific for antigen.

Question 9

The only cells in the body capable of specifically recognizing and distinguishing different antigenic determinants are:

Accepted Answer

A)  macrophages. 
B)  dendritic cells. 
C)  lymphocytes. 
D)  neutrophils. 
A)  macrophages. 
B)  dendritic cells. 
C)  lymphocytes. 
D)  neutrophils.

Question 10

Which type of leukocyte is identified by an ability to form rosettes with sheep red blood cells?

Accepted Answer

A)  T cell 
B)  B cell 
C)  Natural killer cell 
D)  Plasma cell 
A)  T cell 
B)  B cell 
C)  Natural killer cell 
D)  Plasma cell

Question 11

A T cell that is rarely found in secondary lymphoid organs and recognizes a limited number of native epitopes is known as:

Accepted Answer

A)  a helper T cell. 
B)  a gamma-delta T cell. 
C)  a cytotoxic T cell. 
D)  an alpha-beta T cell. 
A)  a helper T cell. 
B)  a gamma-delta T cell. 
C)  a cytotoxic T cell. 
D)  an alpha-beta T cell.

Question 12

All of the following are found on the surface of a mature naïve B cell EXCEPT:

Accepted Answer

A)  IgD 
B)  Lambda and mu chains 
C)  CD19 
D)  Surrogate light chains 
A)  IgD 
B)  Lambda and mu chains 
C)  CD19 
D)  Surrogate light chains

Question 13

The difference in kinetics between a primary and secondary immune response is caused by the presence of:

Accepted Answer

A)  memory cells in the secondary response. 
B)  suppressor cells in the primary response. 
C)  macrophages in the secondary response. 
D)  T cells in the primary response. 
A)  memory cells in the secondary response. 
B)  suppressor cells in the primary response. 
C)  macrophages in the secondary response. 
D)  T cells in the primary response.

Question 14

When IgM on the surface of an immature B cell binds to a self-antigen,which of the following processes can occur?

Accepted Answer

A)  Class switching 
B)  Affinity maturation 
C)  Apoptosis 
D)  Differentiation 
A)  Class switching 
B)  Affinity maturation 
C)  Apoptosis 
D)  Differentiation

Question 15

A plasma cell differs from a B cell in which way?

Accepted Answer

A)  Plasma cells are only found in peripheral blood. 
B)  Only plasma cells secrete circulating antibody. 
C)  Plasma cells secrete cytokines. 
D)  Plasma cells are an immature form in B-cell development. 
A)  Plasma cells are only found in peripheral blood. 
B)  Only plasma cells secrete circulating antibody. 
C)  Plasma cells secrete cytokines. 
D)  Plasma cells are an immature form in B-cell development.

Question 16

Characteristics of T cells emerging from the thymus include which of the following?

Accepted Answer

A)  MHC restricted 
B)  Self-tolerant 
C)  Antigen specific 
D)  All of the above 
A)  MHC restricted 
B)  Self-tolerant 
C)  Antigen specific 
D)  All of the above

Question 17

How are immunoglobulin and T-cell receptors similar?

Accepted Answer

A)  Both have multiple gene segments encoding the variable region. 
B)  Both have an antigen-binding site that recognizes conformational epitopes. 
C)  Both are required for antigen presentation. 
D)  Both can capture numerous different antigens. 
A)  Both have multiple gene segments encoding the variable region. 
B)  Both have an antigen-binding site that recognizes conformational epitopes. 
C)  Both are required for antigen presentation. 
D)  Both can capture numerous different antigens.

Question 18

The purpose or end result of negative selection of the T cell is to ensure:

Accepted Answer

A)  MHC restriction. 
B)  self-tolerance. 
C)  T-cell receptor expression. 
D)  expression of CD3. 
A)  MHC restriction. 
B)  self-tolerance. 
C)  T-cell receptor expression. 
D)  expression of CD3.

Question 19

How are cytotoxic T cells and natural killer cells similar?

Accepted Answer

A)  Both require antibody to be bound to the target cell. 
B)  Both induce apoptosis in the target cell. 
C)  Both recognize peptide plus MHC class I. 
D)  Both kill target cells lacking MHC class I. 
A)  Both require antibody to be bound to the target cell. 
B)  Both induce apoptosis in the target cell. 
C)  Both recognize peptide plus MHC class I. 
D)  Both kill target cells lacking MHC class I.

Question 20

Mutations causing deficiencies in CD40L expression lead to an inability of helper T cells to:

Accepted Answer

A)  kill tumor cells, resulting in an increased risk of cancer. 
B)  activate macrophages, resulting in an inability to clear extracellular pathogens. 
C)  migrate to the site of an infection by chemotaxis, resulting in a slowed response. 
D)  promote class-switching, resulting in high IgM and low IgA and IgG concentrations. 
A)  kill tumor cells, resulting in an increased risk of cancer. 
B)  activate macrophages, resulting in an inability to clear extracellular pathogens. 
C)  migrate to the site of an infection by chemotaxis, resulting in a slowed response. 
D)  promote class-switching, resulting in high IgM and low IgA and IgG concentrations.

Exam 4: Adaptive Immunity

A lymphocyte exhibits the following markers: CD19,IgM,IgD.What is its likely identity?

Which T-cell surface protein is associated with the T-cell receptor and is involved in signal transduction?

The function of CD4+ T cells is:

Which marker is found on the group of T cells that assists B cells in making antibody?

The receptor for antigen on a mature naïve B cell is:

A T-independent antibody response:

T cells that respond against self-antigens are inactivated by:

Which statement best describes the specific antigen receptor that is a part of CD3 found on T cells?

The only cells in the body capable of specifically recognizing and distinguishing different antigenic determinants are:

Which type of leukocyte is identified by an ability to form rosettes with sheep red blood cells?

A T cell that is rarely found in secondary lymphoid organs and recognizes a limited number of native epitopes is known as:

All of the following are found on the surface of a mature naïve B cell EXCEPT:

The difference in kinetics between a primary and secondary immune response is caused by the presence of:

When IgM on the surface of an immature B cell binds to a self-antigen,which of the following processes can occur?

A plasma cell differs from a B cell in which way?

Characteristics of T cells emerging from the thymus include which of the following?

How are immunoglobulin and T-cell receptors similar?

The purpose or end result of negative selection of the T cell is to ensure:

How are cytotoxic T cells and natural killer cells similar?

Mutations causing deficiencies in CD40L expression lead to an inability of helper T cells to:

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters