Question 1

Which of the following represents C3 convertase?

Accepted Answer

A)  C4b2a3b 
B)  C3bBbP 
C)  C1qrs 
D)  BbH 
A)  C4b2a3b 
B)  C3bBbP 
C)  C1qrs 
D)  BbH

Question 2

Which of the following acts as an opsonin?

Accepted Answer

A)  IgD 
B)  C3b 
C)  C5a 
D)  IL-2 
A)  IgD 
B)  C3b 
C)  C5a 
D)  IL-2

Question 3

What reagent is present in a CH50 assay and absent in an AH50 assay?

Accepted Answer

A)  Calcium 
B)  Red blood cells 
C)  Ethylene glycol 
D)  Magnesium 
A)  Calcium 
B)  Red blood cells 
C)  Ethylene glycol 
D)  Magnesium

Question 4

Formation of the membrane attack complex (C5b-C9)is stopped by which factor?

Accepted Answer

A)  Factor H 
B)  Factor I 
C)  C1INH 
D)  S protein 
A)  Factor H 
B)  Factor I 
C)  C1INH 
D)  S protein

Question 5

Which statement about complement components is most accurate?

Accepted Answer

A)  They all are active enzymes. 
B)  They are synthesized only when antigen is present. 
C)  They play a major part in the inflammatory response. 
D)  They are mainly produced in lymphoid tissue. 
A)  They all are active enzymes. 
B)  They are synthesized only when antigen is present. 
C)  They play a major part in the inflammatory response. 
D)  They are mainly produced in lymphoid tissue.

Question 6

Binding of a lectin to a sugar found in bacteria and fungi occurs in which complement pathway?

Accepted Answer

A)  Alternative pathway 
B)  Classical pathway 
C)  MBL pathway 
D)  All of the above 
A)  Alternative pathway 
B)  Classical pathway 
C)  MBL pathway 
D)  All of the above

Question 7

Kidney glomeruli can become obstructed with immune complexes as a result of:

Accepted Answer

A)  properdin deficiency. 
B)  inadequate C3b-mediated opsonization. 
C)  membrane attack complex formation. 
D)  autoantibodies that bind C3bBb. 
A)  properdin deficiency. 
B)  inadequate C3b-mediated opsonization. 
C)  membrane attack complex formation. 
D)  autoantibodies that bind C3bBb.

Question 8

The lectin pathway is initiated by the presence of which of the following?

Accepted Answer

A)  Antibody 
B)  C3 
C)  Mannose 
D)  C1qrs 
A)  Antibody 
B)  C3 
C)  Mannose 
D)  C1qrs

Question 9

Which of the following is a characteristic of complement?

Accepted Answer

A)  It is activated by IgE in the classical pathway. 
B)  It cannot be activated by molecules other than antigen-antibody complexes. 
C)  It plays a role in the lysis of target cells coated with specific antibodies. 
D)  It is enhanced by decay-accelerating factor. 
A)  It is activated by IgE in the classical pathway. 
B)  It cannot be activated by molecules other than antigen-antibody complexes. 
C)  It plays a role in the lysis of target cells coated with specific antibodies. 
D)  It is enhanced by decay-accelerating factor.

Question 10

Identify the condition that would result from a deficiency in complement component C2.

Accepted Answer

A)  Increased vascular permeability 
B)  Hereditary angioedema 
C)  Severe infections with encapsulated bacteria 
D)  Immune complex disease 
A)  Increased vascular permeability 
B)  Hereditary angioedema 
C)  Severe infections with encapsulated bacteria 
D)  Immune complex disease

Question 11

In the alternate pathway,factor B must bind to which of the following to initiate the cascade?

Accepted Answer

A)  Factor I 
B)  C3b 
C)  C4b 
D)  Properdin 
A)  Factor I 
B)  C3b 
C)  C4b 
D)  Properdin

Question 12

C4 binding protein (C4BP)acts in association with which factor to inactivate C4b?

Accepted Answer

A)  Factor B 
B)  Factor D 
C)  Factor I 
D)  C1INH 
A)  Factor B 
B)  Factor D 
C)  Factor I 
D)  C1INH

Question 13

Lack of the complement inhibitor C1INH results in which disease?

Accepted Answer

A)  Hereditary angioedema 
B)  Paroxysmal nocturnal hemoglobinuria 
C)  Immune complex disease 
D)  Meningitis 
A)  Hereditary angioedema 
B)  Paroxysmal nocturnal hemoglobinuria 
C)  Immune complex disease 
D)  Meningitis

Question 14

Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

Accepted Answer

A)  C2 
B)  C3 
C)  C4 
D)  Factor B 
A)  C2 
B)  C3 
C)  C4 
D)  Factor B

Question 15

Which of the following is the correct order of activation of complement in the lectin activation pathway?

Accepted Answer

A)  C1, C4, C2, C3 
B)  MBL, C4, C2, C3 
C)  C3, factor B, C3 
D)  MBL, C2, C3, C4 
A)  C1, C4, C2, C3 
B)  MBL, C4, C2, C3 
C)  C3, factor B, C3 
D)  MBL, C2, C3, C4

Question 16

Which factors are found in all three pathways?

Accepted Answer

A)  Factors B and D 
B)  C4, C2, and C3 
C)  C5 through C9 
D)  C1qrs, C3, and C5 
A)  Factors B and D 
B)  C4, C2, and C3 
C)  C5 through C9 
D)  C1qrs, C3, and C5

Question 17

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

Accepted Answer

A)  C3bBb3b 
B)  C4b2a 
C)  C5b6789 
D)  C3b 
A)  C3bBb3b 
B)  C4b2a 
C)  C5b6789 
D)  C3b

Question 18

Lack of the complement components C5 through C9 may result in which condition?

Accepted Answer

A)  Neisseria infection 
B)  Paroxysmal nocturnal hemoglobinuria 
C)  Atherosclerosis 
D)  Meningitis 
A)  Neisseria infection 
B)  Paroxysmal nocturnal hemoglobinuria 
C)  Atherosclerosis 
D)  Meningitis

Question 19

Which of the following immunoglobulins is able to activate complement?

Accepted Answer

A)  IgA 
B)  IgD 
C)  IgE 
D)  IgM 
A)  IgA 
B)  IgD 
C)  IgE 
D)  IgM

Question 20

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Accepted Answer

A)  C1q, C1r, and C1s. 
B)  C4 and C2. 
C)  C5 and C3. 
D)  C5, C6, C7, and C8 
A)  C1q, C1r, and C1s. 
B)  C4 and C2. 
C)  C5 and C3. 
D)  C5, C6, C7, and C8

Exam 7: Complement System

Which of the following represents C3 convertase?

Which of the following acts as an opsonin?

What reagent is present in a CH50 assay and absent in an AH50 assay?

Formation of the membrane attack complex (C5b-C9)is stopped by which factor?

Which statement about complement components is most accurate?

Binding of a lectin to a sugar found in bacteria and fungi occurs in which complement pathway?

Kidney glomeruli can become obstructed with immune complexes as a result of:

The lectin pathway is initiated by the presence of which of the following?

Which of the following is a characteristic of complement?

Identify the condition that would result from a deficiency in complement component C2.

In the alternate pathway,factor B must bind to which of the following to initiate the cascade?

C4 binding protein (C4BP)acts in association with which factor to inactivate C4b?

Lack of the complement inhibitor C1INH results in which disease?

Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

Which of the following is the correct order of activation of complement in the lectin activation pathway?

Which factors are found in all three pathways?

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

Lack of the complement components C5 through C9 may result in which condition?

Which of the following immunoglobulins is able to activate complement?

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunoproliferative Diseases

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters