Question 1

What percentage of human pre-mRNA is alternatively spliced

Accepted Answer

A)  70 % 
B)  23% 
C)  5% 
D)  2% 
A)  70 % 
B)  23% 
C)  5% 
D)  2%

Question 2

The term ribozyme is given to catalytic RNA molecules.

Accepted Answer

A) True 
 B)False

Question 3

Where does the process of transcription initiate?

Accepted Answer

A)  Promoter 
B)  Terminator 
C)  Regulation sequences 
D)  Transcription factors 
A)  Promoter 
B)  Terminator 
C)  Regulation sequences 
D)  Transcription factors

Question 4

What structural motif is most commonly used by transcription factors in binding to DNA?

Accepted Answer

A)  Zinc-finger 
B)  Helix-turn-helix 
C)  Leucine zipper 
D)  Homeodomain 
A)  Zinc-finger 
B)  Helix-turn-helix 
C)  Leucine zipper 
D)  Homeodomain

Question 5

A main function of TFIID is

Accepted Answer

A)  to recognize the TATA box 
B)  to act as a helicase 
C)  to terminate RNA polymerase II binding 
D)  to phosphorylate the CTD of RNA polymerase II 
A)  to recognize the TATA box 
B)  to act as a helicase 
C)  to terminate RNA polymerase II binding 
D)  to phosphorylate the CTD of RNA polymerase II

Question 6

Prokaryotic genes are colinear with their proteins, but this is not true for most eukaryotic genes

Accepted Answer

A)  True 
B)  False 
C)  It is unknown at this time 
A)  True 
B)  False 
C)  It is unknown at this time

Question 7

RNaseP is not a protein but a ribozyme

Accepted Answer

A) True 
 B)False

Question 8

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

Accepted Answer

A)  In the cytoplasm 
B)  In the nucleolus 
C)  In the endoplasmic reticulum 
D)  In the Golgi body 
E)  Throughout the cell 
A)  In the cytoplasm 
B)  In the nucleolus 
C)  In the endoplasmic reticulum 
D)  In the Golgi body 
E)  Throughout the cell

Question 9

What RNAs do each eukaryotic RNA polymerase produce?

Accepted Answer

A)  RNA pol I - mRNA RNA pol II - tRNA and 5s rRNA
RNA pol III - rRNA 
B)  RNA pol I - rRNA RNA pol II - tRNA and 5s rRNA
RNA pol III - mRNA 
C)  RNA pol I - mRNA RNA pol II - rRNA
RNA pol III - tRNA and 5s rRNA 
D)  RNA pol I - rRNA RNA pol II - mRNA
RNA pol III - tRNA and 5s rRNA 
A)  RNA pol I - mRNA RNA pol II - tRNA and 5s rRNA
RNA pol III - rRNA 
B)  RNA pol I - rRNA RNA pol II - tRNA and 5s rRNA
RNA pol III - mRNA 
C)  RNA pol I - mRNA RNA pol II - rRNA
RNA pol III - tRNA and 5s rRNA 
D)  RNA pol I - rRNA RNA pol II - mRNA
RNA pol III - tRNA and 5s rRNA

Question 10

The process of RNA editing can alter the base sequence of the mRNA following transcription.

Accepted Answer

A) True 
 B)False

Question 11

During the initiation phase of transcription the sigma (σ) factor, which is bound to RNA polymerase, binds into the major groove of DNA and recognizes sequence elements at the promoter. This process forms a closed complex

Accepted Answer

A) True 
 B)False

Question 12

What modification acts to stabilize eukaryotic mRNA?

Accepted Answer

A)  Alternative splicing 
B)  RNA editing 
C)  RNA interference 
D)  Polyadenylation 
E)  Trimming 
A)  Alternative splicing 
B)  RNA editing 
C)  RNA interference 
D)  Polyadenylation 
E)  Trimming

Question 13

What occurs In both prokaryotic and eukaryotic tRNA maturation?

Accepted Answer

A)  The pre tRNA molecule is trimmed by exo and endonucleases 
B)  The pre tRNA is spliced 
C)  The mature tRNA is capped at the 5' end 
D)  There is extensive RNA editing 
A)  The pre tRNA molecule is trimmed by exo and endonucleases 
B)  The pre tRNA is spliced 
C)  The mature tRNA is capped at the 5' end 
D)  There is extensive RNA editing

Question 14

What snRNP holds the exons in place so that they can be connected after the intron is removed?

Accepted Answer

A)  U1 
B)  U2 
C)  U5 
D)  U6 
A)  U1 
B)  U2 
C)  U5 
D)  U6

Question 15

What is the purpose of phosphorylating the carboxy terminal domain (CTD)?

Accepted Answer

A)  Convert from initiation to the elongation stage 
B)  To aid in transcriptional initiation 
C)  Phosphorylate transcription factors 
D)  To aid in promoter recognition 
A)  Convert from initiation to the elongation stage 
B)  To aid in transcriptional initiation 
C)  Phosphorylate transcription factors 
D)  To aid in promoter recognition

Question 16

The Prinbow box contains a CACAAC consensus sequence located in the -100 region of the promoter.

Accepted Answer

A) True 
 B)False

Question 17

The RNA polymerase forms a closed complex during the process of elongation during transcription.

Accepted Answer

A) True 
 B)False

Question 18

What basal transcription factor is a helicase?

Accepted Answer

A)  TFIID 
B)  TFIIH 
C)  TFIIF 
D)  TFIIB 
A)  TFIID 
B)  TFIIH 
C)  TFIIF 
D)  TFIIB

Question 19

What region in eukaryotic genes usually contains the majority of regulatory elements such as GC and CAAT boxes?

Accepted Answer

A)  0 to 50 
B)  -50 to 0 
C)  -50 to -100 
D)  -100 to -150 
A)  0 to 50 
B)  -50 to 0 
C)  -50 to -100 
D)  -100 to -150

Question 20

If a nucleotide in a eukaryotic mRNA coding sequence does not appear in the genomic DNA sequence the most likely modification to have occurred is

Accepted Answer

A)  Alternative splicing 
B)  RNA editing 
C)  5' capping 
D)  Polyadenylation 
E)  Trimming 
A)  Alternative splicing 
B)  RNA editing 
C)  5' capping 
D)  Polyadenylation 
E)  Trimming

Exam 12: Gene Transcription and Rna Modification

What percentage of human pre-mRNA is alternatively spliced

The term ribozyme is given to catalytic RNA molecules.

Where does the process of transcription initiate?

What structural motif is most commonly used by transcription factors in binding to DNA?

A main function of TFIID is

Prokaryotic genes are colinear with their proteins, but this is not true for most eukaryotic genes

RNaseP is not a protein but a ribozyme

In eukaryotic organisms, the processing of the 45S rRNA into 5.8S, 18S, and 28S rRNA occurs where?

What RNAs do each eukaryotic RNA polymerase produce?

The process of RNA editing can alter the base sequence of the mRNA following transcription.

During the initiation phase of transcription the sigma (σ) factor, which is bound to RNA polymerase, binds into the major groove of DNA and recognizes sequence elements at the promoter. This process forms a closed complex

What modification acts to stabilize eukaryotic mRNA?

What occurs In both prokaryotic and eukaryotic tRNA maturation?

What snRNP holds the exons in place so that they can be connected after the intron is removed?

What is the purpose of phosphorylating the carboxy terminal domain (CTD)?

The Prinbow box contains a CACAAC consensus sequence located in the -100 region of the promoter.

The RNA polymerase forms a closed complex during the process of elongation during transcription.

What basal transcription factor is a helicase?

What region in eukaryotic genes usually contains the majority of regulatory elements such as GC and CAAT boxes?

If a nucleotide in a eukaryotic mRNA coding sequence does not appear in the genomic DNA sequence the most likely modification to have occurred is

Overview of Genetics

Mendelian Inheritance

Chromosome Transmission During Cell Division and Sexual Reproduction

Extensions of Mendelian Inheritance

Non-Mendelian Inheritance

Genetic Linkage and Mapping in Eukaryotes

Genetic Transfer and Mapping in Bacteria

Variation in Chromosome Structure and Number

Molecular Structure of Dna and Rna

Chromosome Organization and Molecular Structure

Dna Replication

Translation of Mrna

Gene Regulation in Bacteria

Gene Regulation in Eukaryotes I: Transcriptional and Translation Regulation

Gene Regulation in Eukaryotes Ii: Epigenetics

Non-Coding Rnas

Genetics of Viruses

Gene Mutation and Dna Repair

Recombination, Immunogenetics, and Transposition

Molecular Technologies

Biotechnology

Genomics I: Analysis of Dna

Genomics Ii: Functional Genomics, Proteomics, and Bioinformatics

Medical Genetics and Cancer

Developmental Genetics

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Complex and Quantitative Traits

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