Question 1

The invariant amino acids in each peptide motif bound by MHC proteins are called

Accepted Answer

A) anchor residues. 
B) MHC peptides. 
C) antigen-binding immunoglobulins. 
D) TCR peptides. 
A) anchor residues. 
B) MHC peptides. 
C) antigen-binding immunoglobulins. 
D) TCR peptides.

Question 2

Predict the consequence for an individual of a deleterious genetic mutation in the gene for TLR-4.

Accepted Answer

A mutation that changes TLR-4 would hamp

Question 3

Each immunoglobulin or TCR interacts with a single antigen,but MHC proteins can interact with more than one antigen.

Accepted Answer

A) True 
 B)False

Question 4

Which of the following biomolecules interact with toll-like receptors (TLRs)?

Accepted Answer

A) bacterial LPS 
B) immunoglobulins 
C) major histocompatibility complex proteins 
D) none of these 
A) bacterial LPS 
B) immunoglobulins 
C) major histocompatibility complex proteins 
D) none of these

Question 5

B cells react with antigens through TCR antigen receptors.

Accepted Answer

A) True 
 B)False

Question 6

Clonal anergy is a state of

Accepted Answer

A) antibody production. 
B) high energy. 
C) unresponsiveness. 
D) high energy and antibody production. 
A) antibody production. 
B) high energy. 
C) unresponsiveness. 
D) high energy and antibody production.

Question 7

Design five amino acid peptides that could be bound by a single hypothetical class I MHC protein.The MHC proteins binds peptides that are 10 amino acids long and have two anchor residues,tyrosine and isoleucine,at positions 2 and 5.

Accepted Answer

Answers will vary because diff

Question 8

A patient is waiting for a kidney transplant.In order for the transplant to be successful,the donated kidney (the graft)must "match" with the recipient.What has to "match" between the donor and the recipient? Why is matching tissue more difficult than matching blood types?

Accepted Answer

The immune system uses major histocompat

Question 9

Affinity maturation is one of the factors responsible for a stronger secondary immune response.

Accepted Answer

A) True 
 B)False

Question 10

What role does the C domain play in cell surface proteins that interact directly with antigens?

Accepted Answer

C domains provide structural integrity f

Question 11

Why is the secondary immune response stronger in regard to antibodies?

Accepted Answer

Somatic hypermutation creates B cells be

Question 12

Some immature B cells are reactive to self-antigens but do not become activated even when exposed to high concentrations of self-antigens.

Accepted Answer

A) True 
 B)False

Question 13

Antibodies are insoluble proteins.

Accepted Answer

A) True 
 B)False

Question 14

Somatic hypermutation mechanisms generate TCR diversity.

Accepted Answer

A) True 
 B)False

Question 15

Which of the following are proteins that interact directly with antigens during the adaptive immune response?

Accepted Answer

A) immunoglobins 
B) major histocompatibility complex 
C) T cell receptors 
D) all of these 
A) immunoglobins 
B) major histocompatibility complex 
C) T cell receptors 
D) all of these

Question 16

All TLR can react with only one specific PAMP.

Accepted Answer

A) True 
 B)False

Question 17

Assuming that each heavy and light chain has an equal chance to be expressed in each cell,approximately how many possible antibodies can be expressed?

Accepted Answer

A) 192 
B) 1,920 
C) 19,200 
D) 1,920,000 
A) 192 
B) 1,920 
C) 19,200 
D) 1,920,000

Question 18

Selection against self-reactive clones results in the development of tolerance.

Accepted Answer

A) True 
 B)False

Question 19

The occurrence of multiple alleles at a specific locus is called

Accepted Answer

A) signal transduction. 
B) the variable domain. 
C) polymorphism. 
D) allelic exclusion. 
A) signal transduction. 
B) the variable domain. 
C) polymorphism. 
D) allelic exclusion.

Question 20

In B cell selection and tolerance,if no signal is generated from ________ cells,the B cells remain unresponsive.

Accepted Answer

A) TC 
B) TH 
C) B₇ 
D) CD₂₈ 
A) TC 
B) TH 
C) B₇ 
D) CD₂₈

Exam 26: Molecular Immunology

The invariant amino acids in each peptide motif bound by MHC proteins are called

Predict the consequence for an individual of a deleterious genetic mutation in the gene for TLR-4.

Each immunoglobulin or TCR interacts with a single antigen,but MHC proteins can interact with more than one antigen.

Which of the following biomolecules interact with toll-like receptors (TLRs)?

B cells react with antigens through TCR antigen receptors.

Clonal anergy is a state of

Design five amino acid peptides that could be bound by a single hypothetical class I MHC protein.The MHC proteins binds peptides that are 10 amino acids long and have two anchor residues,tyrosine and isoleucine,at positions 2 and 5.

A patient is waiting for a kidney transplant.In order for the transplant to be successful,the donated kidney (the graft)must "match" with the recipient.What has to "match" between the donor and the recipient? Why is matching tissue more difficult than matching blood types?

Affinity maturation is one of the factors responsible for a stronger secondary immune response.

What role does the C domain play in cell surface proteins that interact directly with antigens?

Why is the secondary immune response stronger in regard to antibodies?

Some immature B cells are reactive to self-antigens but do not become activated even when exposed to high concentrations of self-antigens.

Antibodies are insoluble proteins.

Somatic hypermutation mechanisms generate TCR diversity.

Which of the following are proteins that interact directly with antigens during the adaptive immune response?

All TLR can react with only one specific PAMP.

Assuming that each heavy and light chain has an equal chance to be expressed in each cell,approximately how many possible antibodies can be expressed?

Selection against self-reactive clones results in the development of tolerance.

The occurrence of multiple alleles at a specific locus is called

In B cell selection and tolerance,if no signal is generated from ________ cells,the B cells remain unresponsive.

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