Question 1

At the center of a glycogen molecule is:

Accepted Answer

A)  glucose. 
B)  glycogenin. 
C)  UDP-glucose. 
D)  glycogen synthase. 
E)  glycogen phosphorylase. 
A)  glucose. 
B)  glycogenin. 
C)  UDP-glucose. 
D)  glycogen synthase. 
E)  glycogen phosphorylase. B

Question 2

Hydrolysis of _______________ drives the formation of UDP-glucose.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease J

Question 3

_______________ is the storage disease in which light exercise results in cramps.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease L

Question 4

Glycogen synthase catalyzes the transfer of a glucose residue from UDP-glucose to one of the __________________ ends of glycogen.

Accepted Answer

The answer of Glycogen synthase catalyzes the transfer of a...

Question 5

Explain why patients with McArdle disease do not accumulate lactate during light exercise.

Accepted Answer

Their glycolytic rate is lower

Question 6

Glycogenin:

Accepted Answer

A)  consists of dimmer proteins. 
B)  self-assembles eight glycosyl units. 
C)  is the primer for glycogen synthase. 
D)  B and C. 
E)  All of the above. 
A)  consists of dimmer proteins. 
B)  self-assembles eight glycosyl units. 
C)  is the primer for glycogen synthase. 
D)  B and C. 
E)  All of the above.

Question 7

Glucosyl units are added to the _______________ end, or terminal, of glycogen.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 8

_______________ is the activated form of glucose that is required for glycogen synthesis.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 9

Type I diabetes leads to ______________ in the liver.

Accepted Answer

A)  increased glucose transport 
B)  increased glycogen synthesis 
C)  a decrease in fructose 2,6-phosphate 
D)  a decrease in gluconeogenesis 
E)  All of the above. 
A)  increased glucose transport 
B)  increased glycogen synthesis 
C)  a decrease in fructose 2,6-phosphate 
D)  a decrease in gluconeogenesis 
E)  All of the above.

Question 10

Synthesis of glycogen starts with the phosphate group transfer from UTP to _______________.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 11

The protein _______________ serves as the primer used by glycogen synthase.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 12

______________ results from a loss or inactivation of insulin receptors.

Accepted Answer

A)  Hypoglycemia 
B)  Hyperinsulinemia 
C)  Type I diabetes 
D)  Type II diabetes 
E)  None of the above. 
A)  Hypoglycemia 
B)  Hyperinsulinemia 
C)  Type I diabetes 
D)  Type II diabetes 
E)  None of the above.

Question 13

There is rare disease in which a critical serine in muscle glycogenin is mutated to alanine, which results in what biochemical outcome?

Accepted Answer

The muscle isoform of glycogen will not

Question 14

Explain the conversion between both a and b, and R and T forms of phosphorylase.

Accepted Answer

Phosphorylase b is converted to phosphor

Question 15

_______________ dissociates from phosphorylase a in the T state.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 16

The glycogen branching enzyme moves a block of __________________ (or so) glucose residues to from a branch point at least four residues from a preexisting branch.

Accepted Answer

The answer of The glycogen branching enzyme moves a block...

Question 17

Glycogen _______________ is inhibited by phosphorylase kinase.

Accepted Answer

A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease 
A) UDP-glucose 
B) nonreducing 
C) synthesis 
D) glucose 
E) glycogenin
F)Von Gierke disease
G)glycogen synthase
H)UTP-glucose
I)protein phosphatase 1 (PP1)
J)PPi
K)glycogen phosphate
L)McArdle disease

Question 18

Which enzyme(s) is/are required to synthesize ɑ-1,4-glycosidic bonds in glycogen?

Accepted Answer

A)  glycogen synthase 
B)  UDP-glucose phosphorylase 
C)  branching enzyme 
D)  A and B 
E)  B and C 
A)  glycogen synthase 
B)  UDP-glucose phosphorylase 
C)  branching enzyme 
D)  A and B 
E)  B and C

Question 19

Insulin binds to its receptor and causes what protein to be activated in the cytoplasm?

Accepted Answer

Insulin re

Question 20

What did Carl and Gerti Cori discover about the cause of von Gierke disease? Briefly explain how this information helps to explain the symptoms of the disease.

Accepted Answer

They discovered that the cause of von Gi

Exam 25: Glycogen Synthesis

At the center of a glycogen molecule is:

Hydrolysis of _______________ drives the formation of UDP-glucose.

_______________ is the storage disease in which light exercise results in cramps.

Glycogen synthase catalyzes the transfer of a glucose residue from UDP-glucose to one of the __________________ ends of glycogen.

Explain why patients with McArdle disease do not accumulate lactate during light exercise.

Glycogenin:

Glucosyl units are added to the _______________ end, or terminal, of glycogen.

_______________ is the activated form of glucose that is required for glycogen synthesis.

Type I diabetes leads to ______________ in the liver.

Synthesis of glycogen starts with the phosphate group transfer from UTP to _______________.

The protein _______________ serves as the primer used by glycogen synthase.

______________ results from a loss or inactivation of insulin receptors.

There is rare disease in which a critical serine in muscle glycogenin is mutated to alanine, which results in what biochemical outcome?

Explain the conversion between both a and b, and R and T forms of phosphorylase.

_______________ dissociates from phosphorylase a in the T state.

The glycogen branching enzyme moves a block of __________________ (or so) glucose residues to from a branch point at least four residues from a preexisting branch.

Glycogen _______________ is inhibited by phosphorylase kinase.

Which enzyme(s) is/are required to synthesize ɑ-1,4-glycosidic bonds in glycogen?

Insulin binds to its receptor and causes what protein to be activated in the cytoplasm?

What did Carl and Gerti Cori discover about the cause of von Gierke disease? Briefly explain how this information helps to explain the symptoms of the disease.

Biochemistry and the Unity of Life

Water, Weak Bonds, and the Generation of Order Out of Chaos

Amino Acids

Protein Three-Dimensional Structure

Techniques in Protein Biochemistry

Basic Concepts of Enzyme Action

Kinetics and Regulation

Mechanisms and Inhibitors

Hemoglobin: an Allosteric Protein

Carbohydrates

Lipids

Membrane Structure and Function

Signal Transduction Pathways

Digestion: Turning a Meal Into Cellular Biochemicals

Metabolism: Basic Concepts and Design

Glycolysis

Gluconeogenesis

Preparation for the Cycle

Harvesting Electrons From the Cycle

The Electron Transport Chain

The Proton-Motive Force

The Light Reactions

The Calvin Cycle

Glycogen Degradation

The Pentose Phosphate Pathway

Fatty Acid Degredation

Fatty Acid Synthesis

Lipid Synthesis

Amino Acid Degradation and the Urea Cycle

Amino Acids Synthesis

Nucleotide Metabolism

The Structure of Informational Macromolecules: Dna and Rna

DNA Replication

DNA Repair and Recombination

RNA Synthesis and Regulation in Prokaryotes

Gene Expression in Eukaryotes

RNA Processing in Eukaryotes

The Genetic Code

The Mechanism of Protein Synthesis

Recombinant Dna Techniques

Filters