Exam 26: The Pentose Phosphate Pathway

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Which biosynthetic pathway requires NADH?

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D

What are the reactions in the oxidative phase of the pentose phosphate pathway?

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The first reaction is the oxidation of C1 of glucose 6-phosphate to 6-phosphoglucono-δ-lactone by the enzyme glucose 6-phosphate dehydrogenase. The lactone product is hydrolyzed to 6-phosphogluconate by the enzyme lactonase. Finally, 6-phosphogluconate is further oxidized and decarboxylated to ribulose 5-phosphate and CO2 by 6-phosphogluconate dehydrogenase.

_________________ is the committed step of the pentose phosphate pathway.

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glucose 6-phosphate dehydrogenase

What is the net reaction of the transketolase and transaldolase steps?

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The currency of reducing power is:

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What is a primary difference between the oxidation of glucose to CO2 by glycolysis and the citric acid cycle versus the oxidation via the pentose phosphate pathway?

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The manifestation of the disease is actually caused by a defect in _________________.

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Choose the correct answer from the list below. Not all of the answers will be used. -Two molecules of ____________ are formed in phase II of the pentose phosphate pathway.

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In mode two:

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Choose the correct answer from the list below. Not all of the answers will be used. -____________ is the key source of biosynthetic reducing equivalents.

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The enzyme transketolase transfers a _________________-carbon fragment from a ketose to an aldose.

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Hemolytic anemia is caused by a deficiency of the enzyme _________________.

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How can a deficiency of glucose 6-phosphate confer a physiological advantage?

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Which enzyme controls the pentose phosphate pathway?

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NADPH is required for which of the following detoxification reactions or enzymes?

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Which sugar(s) is/are converted into ribulose 5-phosphate by a single enzymatic step?

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How does NADPH protect red blood cells from hemolysis?

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Choose the correct answer from the list below. Not all of the answers will be used. -Ribulose 5-phosphate is the result of the ____________ phase.

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NADPH is required by the liver and adipose for synthesis of _________________.

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Choose the correct answer from the list below. Not all of the answers will be used. -The prosthetic group ____________ is tightly bound to the enzyme transketolase.

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