Question 1

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Accepted Answer

PRPP

Question 2

Choose the correct answer from the list below. Not all of the answers will be used.
-The methyl donor to make TMP is _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage F

Question 3

Choose the correct answer from the list below. Not all of the answers will be used.
-CTP is formed by the amination of _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage E

Question 4

How is ATCase, a key enzyme in pyrimidine biosynthesis, inhibited?

Accepted Answer

ATCase is inhibited by CTP, th

Question 5

The synthesis of CTP from UTP requires UTP and:

Accepted Answer

A)  glutamine and ATP. 
B)  glycine and ATP. 
C)  glutamine, ATP, and NADH. 
D)  All of the above. 
E)  None of the above. 
A)  glutamine and ATP. 
B)  glycine and ATP. 
C)  glutamine, ATP, and NADH. 
D)  All of the above. 
E)  None of the above.

Question 6

Allopurinol is used to treat gout and is an inhibitor of the enzyme(s):

Accepted Answer

A)  xanthine oxidase. 
B)  xanthine hydrolase. 
C)  hypoxanthine-guanine phosphoribosyltransferase. 
D)  All of the above. 
E)  None of the above. 
A)  xanthine oxidase. 
B)  xanthine hydrolase. 
C)  hypoxanthine-guanine phosphoribosyltransferase. 
D)  All of the above. 
E)  None of the above.

Question 7

The displacing nucleophile in pyrimidine synthesis is typically:

Accepted Answer

A)  ammonia or an amino group. 
B)  a metal ion. 
C)  coenzyme A. 
D)  All of the above. 
E)  None of the above. 
A)  ammonia or an amino group. 
B)  a metal ion. 
C)  coenzyme A. 
D)  All of the above. 
E)  None of the above.

Question 8

The ultimate reductant in synthesis of deoxyribonucleotides is:

Accepted Answer

A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  quinone. 
E)  None of the above. 
A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  quinone. 
E)  None of the above.

Question 9

Fluorouracil acts as an analog of __________________.

Accepted Answer

The answer of Fluorouracil acts as an analog of __________________....

Question 10

How is pyrimidine biosynthesis regulated?

Accepted Answer

Pyrimidine biosynthesis is regulated by

Question 11

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Accepted Answer

severe com

Question 12

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Accepted Answer

The answer of Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate...

Question 13

Inosinate can be converted to:

Accepted Answer

A)  AMP. 
B)  GMP. 
C)  UMP. 
D)  A or B. 
E)  A, B, or C. 
A)  AMP. 
B)  GMP. 
C)  UMP. 
D)  A or B. 
E)  A, B, or C.

Question 14

What are advantages of high urate levels?

Accepted Answer

Urate is a highly ef

Question 15

What reaction actually forms the six-member ring found in pyrimidines?

Accepted Answer

The reaction between carbamoyl phosphate

Question 16

Choose the correct answer from the list below. Not all of the answers will be used.
-A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n) _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 17

Which amino acid side chain in thymidylate synthase activates the ring of dUMP, making C-5 a good nucleophile?

Accepted Answer

A)  cysteine 
B)  aspartate 
C)  glutamine 
D)  tyrosine 
E)  serine 
A)  cysteine 
B)  aspartate 
C)  glutamine 
D)  tyrosine 
E)  serine

Question 18

The competitive inhibitor(s) of dihydrofolate reductase is/are:

Accepted Answer

A)  aminopterin 
B)  methotrexate 
C)  fluorouracil 
D)  A and B 
E)  B and C 
A)  aminopterin 
B)  methotrexate 
C)  fluorouracil 
D)  A and B 
E)  B and C

Question 19

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

Accepted Answer

The answer of __________________ disease is caused by a genetic...

Question 20

Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Exam 32: Nucleotide Metabolism

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Choose the correct answer from the list below. Not all of the answers will be used. -The methyl donor to make TMP is _________________.

Choose the correct answer from the list below. Not all of the answers will be used. -CTP is formed by the amination of _________________.

How is ATCase, a key enzyme in pyrimidine biosynthesis, inhibited?

The synthesis of CTP from UTP requires UTP and:

Allopurinol is used to treat gout and is an inhibitor of the enzyme(s):

The displacing nucleophile in pyrimidine synthesis is typically:

The ultimate reductant in synthesis of deoxyribonucleotides is:

Fluorouracil acts as an analog of __________________.

How is pyrimidine biosynthesis regulated?

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Inosinate can be converted to:

What are advantages of high urate levels?

What reaction actually forms the six-member ring found in pyrimidines?

Choose the correct answer from the list below. Not all of the answers will be used. -A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n) _________________.

Which amino acid side chain in thymidylate synthase activates the ring of dUMP, making C-5 a good nucleophile?

The competitive inhibitor(s) of dihydrofolate reductase is/are:

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Biochemistry and the Unity of Life

Water, Weak Bonds, and the Generation of Order Out of Chaos

Amino Acids

Protein Three-Dimensional Structure

Techniques in Protein Biochemistry

Basic Concepts of Enzyme Action

Kinetics and Regulation

Mechanisms and Inhibitors

Hemoglobin: an Allosteric Protein

Carbohydrates

Lipids

Membrane Structure and Function

Signal Transduction Pathways

Digestion: Turning a Meal Into Cellular Biochemicals

Metabolism: Basic Concepts and Design

Glycolysis

Gluconeogenesis

Preparation for the Cycle

Harvesting Electrons From the Cycle

The Electron Transport Chain

The Proton-Motive Force

The Light Reactions

The Calvin Cycle

Glycogen Degradation

Glycogen Synthesis

The Pentose Phosphate Pathway

Fatty Acid Degredation

Fatty Acid Synthesis

Lipid Synthesis

Amino Acid Degradation and the Urea Cycle

Amino Acids Synthesis

The Structure of Informational Macromolecules: Dna and Rna

DNA Replication

DNA Repair and Recombination

RNA Synthesis and Regulation in Prokaryotes

Gene Expression in Eukaryotes

RNA Processing in Eukaryotes

The Genetic Code

The Mechanism of Protein Synthesis

Recombinant DNA Techniques

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