Exam 10: Genetic Linkage, Sex-Linkage, and Other Non-Mendelian Inheritance Mechanisms

Which phrase best describes chromosomal nondisjunction?

What typically leads to cancers associated with mammalian insulin growth factor 2 (Igf2)?

Which of the following most likely describes an individual who is a "carrier" of a genetically inherited disease?

Consider the following genetic study involving two autosomal genes. One of these, eye colour, has the dominant allele (R) for red eye colour and the recessive allele (r) for yellow eye colour. The other has the dominant allele (T) leading to paws with thumbs, while the recessive allele (t) codes for paws without thumbs. Presuming no linkage between the genes, what should be the phenotype ratio of the offspring produced by a testcross (RrTt × rrtt)?

Suppose that you examine a vial of 100 flies that are all offspring from a single genetic cross, and you find only red-eyed females and red-eyed males present. You allow these flies to interbreed, and in the next generation you find all the females are red-eyed, but you find both red-eyed and white-eyed males. The allele for red eye colour (X^w+) is dominant over the allele for white eye colour (X^w). Which of the following best describes the genotypes of the original parents?

A mutation in the human gene for a fibroblast growth factor receptor (FGFR) is related to cartilage formation. Which disorder does this mutation appear to be responsible for?

Figure 10-2 -In Figure 10-2, what type of change in the chromosomes is depicted?

Suppose that you are a genetic counsellor, and a couple comes to you with concerns that if they have a child together, it could have hemophilia. Suppose also that neither one of them has hemophilia, but the woman's biological father did have an X-linked recessive form of hemophilia. Which of the following is the best advice you could give them?

Which process is generally the cause for the production of recombinant offspring for two genes on the same chromosome?

About 10% to 15% of African Americans are carriers of an autosomal recessive genetic disorder in which a defective version of hemoglobin is produced. What is the name of this disorder?

Suppose that in Drosophila melanogaster, the allele for red eyes is dominant over the allele for purple eyes, and the allele for a grey body is dominant over the allele for a black body. Also suppose that a testcross was done to check for genetic linkage between the genes for these traits, with the following results for the offspring: 478 flies with red eyes and a black body 27 flies with red eyes and a grey body 462 flies with purple eyes and a grey body 33 flies with purple eyes and a black body Which of the following best represents the map distance between the genes for these two traits?

Match each of the following genetic conditions with its mode of inheritance. A mode of inheritance may be used once, more than once, or not at all. -cystic fibrosis

Suppose that a woman with normal blood clotting mates with a man who has X-linked hemophilia. Given that the woman is heterozygous for the trait, which statement best predicts the outcomes of their mating?