Exam 18: Preparation for the Cycle

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -________________ is a large, multi-subunit enzyme complex that links glycolysis and the citric acid cycle under aerobic conditions.

Beriberi symptoms are similar to those of which disease?

E2 of the PDH complex contains a lipoyl group that is covalently attached to a __________________ residue of the enzyme.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -In the presence of oxygen, pyruvate is converted to ________________.

What are the two advantages that are derived from the coordinated actions of the three enzymes in the PDH complex?

How does the term "mad as a hatter" realistically reflect the condition?

What is the key means of regulation of PDH?

Which of the following conditions will activate PDH kinase, which catalyzes the phorphorylation and inactivation of E1 in the PDH complex?

Which of the following vitamins are precursors to coenzymes that are necessary for the formation of acetyl CoA from pyruvate?

Pyruvate dehydrogenase is _______________ when ATP-ADP ratios are high.

The high-energy charge which results in increasing concentration of NADH __________________ the activity of PDH.

Pyruvate is decarboxylated by which subunit of the PDH?

What coenzyme is required for the decarboxylation reaction in PDH and what is the vitamin precursor?

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -________________ provides a flexible linker between active siteswithin the pyruvate dehydrogenase (PDH) complex.

What are the three enzyme subunits in the PDH complex and the reactions they catalyze?

Which enzyme(s) is/are responsible for the following reaction? Pyruvate + CoA + NAD+ → Acetyl CoA + NADH + H+ + CO2

E1 of the PDH complex requires the coenzyme __________________ for proper activity.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The coenzyme ________________ is the prosthetic group in the decarboxylation of pyruvate.

PDH phosphatase deficiency results in which condition?

__________________ inserts the lipoamide arm of the Sulfhydryl (− SH) domain deep into the channel in E1.