Question 1

Describe the reaction by which carbamoyl phosphate synthetase acquires an ammonia to make carbamoyl phosphate.

Accepted Answer

A component of the e

Question 2

How is the reciprocal use of nucleotides useful in purine synthesis?

Accepted Answer

AMP synthesis requires GTP, wh

Question 3

Tetrahydrofolate is generated from dihydrofolate by dihydrofolate reductase and uses the reductant:

Accepted Answer

A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  riboflavin. 
E)  None of the above. 
A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  riboflavin. 
E)  None of the above.

Question 4

Choose the correct answer from the list below. Not all of the answers will be used.
-High levels of urate cause the disease _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 5

In __________________ biosynthesis, the base is assembled first and then attached to ribose.

Accepted Answer

The answer of In __________________ biosynthesis, the base is assembled...

Question 6

Choose the correct answer from the list below. Not all of the answers will be used.
-The intermediate between inosinate and guanylate is _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 7

Why is nucleotide synthesis an important pathway for medical intervention? What types of disease could be treated using this information?

Accepted Answer

Interference of nucleotide synthesis cou

Question 8

Why do purine salvage pathways save the cell energy?

Accepted Answer

Free purines can be

Question 9

TMP is made from:

Accepted Answer

A)  dTMP. 
B)  dUMP. 
C)  CTP. 
D)  ATP. 
E)  None of the above. 
A)  dTMP. 
B)  dUMP. 
C)  CTP. 
D)  ATP. 
E)  None of the above.

Question 10

The source(s) of NH2 groups in the synthesis of nucleotides is/are:

Accepted Answer

A)  aspartate 
B)  glutamine 
C)  glycine 
D)  A and B 
E)  A, B, and C 
A)  aspartate 
B)  glutamine 
C)  glycine 
D)  A and B 
E)  A, B, and C

Question 11

What is the advantage of channeling intermediates by carbamoyl phosphate synthetase?

Accepted Answer

There are three distinct sites in the en

Question 12

Which enzyme carries out this reaction: XDP + YTP ↔ XTP + YDP

Accepted Answer

A)  nucleoside triphosphate kinase 
B)  nucleoside diphosphate kinase 
C)  nucleoside diphosphate phosphorylase 
D)  nucleoside triphosphate phosphorylase 
E)  None of the above. 
A)  nucleoside triphosphate kinase 
B)  nucleoside diphosphate kinase 
C)  nucleoside diphosphate phosphorylase 
D)  nucleoside triphosphate phosphorylase 
E)  None of the above.

Question 13

DNA is built from __________________.

Accepted Answer

deoxyribon

Question 14

Choose the correct answer from the list below. Not all of the answers will be used.
-The final product of purine degradation is _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 15

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

Accepted Answer

ribonucleo

Question 16

Dihydrofolate reductase is an excellent target for anticancer drugs because it is critical in the synthesis of __________________.

Accepted Answer

The answer of Dihydrofolate reductase is an excellent target for...

Question 17

Given the function of nucleotides, would you expect their synthesis to be simple or complex and diverse?

Accepted Answer

Simple, as these molecules were importan

Question 18

Choose the correct answer from the list below. Not all of the answers will be used.
-Purines and pyrimidines are derived from _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 19

What is a general theme in purine ring synthesis, in terms of reaction logic and mechanism?

Accepted Answer

The first six steps are similar in that

Question 20

Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Exam 32: Nucleotide Metabolism

Describe the reaction by which carbamoyl phosphate synthetase acquires an ammonia to make carbamoyl phosphate.

How is the reciprocal use of nucleotides useful in purine synthesis?

Tetrahydrofolate is generated from dihydrofolate by dihydrofolate reductase and uses the reductant:

Choose the correct answer from the list below. Not all of the answers will be used. -High levels of urate cause the disease _________________.

In __________________ biosynthesis, the base is assembled first and then attached to ribose.

Choose the correct answer from the list below. Not all of the answers will be used. -The intermediate between inosinate and guanylate is _________________.

Why is nucleotide synthesis an important pathway for medical intervention? What types of disease could be treated using this information?

Why do purine salvage pathways save the cell energy?

TMP is made from:

The source(s) of NH2 groups in the synthesis of nucleotides is/are:

What is the advantage of channeling intermediates by carbamoyl phosphate synthetase?

Which enzyme carries out this reaction: XDP + YTP ↔ XTP + YDP

DNA is built from __________________.

Choose the correct answer from the list below. Not all of the answers will be used. -The final product of purine degradation is _________________.

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

Dihydrofolate reductase is an excellent target for anticancer drugs because it is critical in the synthesis of __________________.

Given the function of nucleotides, would you expect their synthesis to be simple or complex and diverse?

Choose the correct answer from the list below. Not all of the answers will be used. -Purines and pyrimidines are derived from _________________.

What is a general theme in purine ring synthesis, in terms of reaction logic and mechanism?

Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

Biochemistry and the Unity of Life

Water, Weak Bonds, and the Generation of Order Out of Chaos

Amino Acids

Protein Three-Dimensional Structure

Techniques in Protein Biochemistry

Basic Concepts of Enzyme Action

Kinetics and Regulation

Mechanisms and Inhibitors

Hemoglobin: an Allosteric Protein

Carbohydrates

Lipids

Membrane Structure and Function

Signal Transduction Pathways

Digestion: Turning a Meal Into Cellular Biochemicals

Metabolism: Basic Concepts and Design

Glycolysis

Gluconeogenesis

Preparation for the Cycle

Harvesting Electrons From the Cycle

The Electron Transport Chain

The Proton-Motive Force

The Light Reactions

The Calvin Cycle

Glycogen Degradation

Glycogen Synthesis

The Pentose Phosphate Pathway

Fatty Acid Degredation

Fatty Acid Synthesis

Lipid Synthesis

Amino Acid Degradation and the Urea Cycle

Amino Acids Synthesis

The Structure of Informational Macromolecules: Dna and Rna

DNA Replication

DNA Repair and Recombination

RNA Synthesis and Regulation in Prokaryotes

Gene Expression in Eukaryotes

RNA Processing in Eukaryotes

The Genetic Code

The Mechanism of Protein Synthesis

Recombinant DNA Techniques

Filters

The source(s) of NH₂ groups in the synthesis of nucleotides is/are: