Question 1

The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they

Accepted Answer

A) are inherently repetitive. 
B) contain large numbers of LINEs, which interfere with sequence annotation. 
C) interfere with BLAST analysis. 
D) are often found in areas of constitutive heterochromatin. 
A) are inherently repetitive. 
B) contain large numbers of LINEs, which interfere with sequence annotation. 
C) interfere with BLAST analysis. 
D) are often found in areas of constitutive heterochromatin. A

Question 2

When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

Accepted Answer

A) eukaryotic genomes are larger than prokaryotic genomes. 
B) eukaryotic genomes are smaller than prokaryotic genomes. 
C) the size of the organism determines the size of the genome. 
D) larger and more complex organisms have more genes than smaller, less complex organisms. 
A) eukaryotic genomes are larger than prokaryotic genomes. 
B) eukaryotic genomes are smaller than prokaryotic genomes. 
C) the size of the organism determines the size of the genome. 
D) larger and more complex organisms have more genes than smaller, less complex organisms. A

Question 3

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Accepted Answer

A) synteny. 
B) exosymbiosis. 
C) endosymbiosis. 
D) draft sequencing by the nucleosome. 
A) synteny. 
B) exosymbiosis. 
C) endosymbiosis. 
D) draft sequencing by the nucleosome. C

Question 4

Using actual landmarks within DNA sequences, scientists can generate a _______ map.

Accepted Answer

A) genetic 
B) DNA 
C) physical 
D) chromosomal 
A) genetic 
B) DNA 
C) physical 
D) chromosomal

Question 5

How did the rice genome project influence other genome projects?

Accepted Answer

A) It was the first genome sequenced, so it proved it could be done. 
B) It sped up the genome analysis of other cereal crops, due to synteny. 
C) It sped up the analysis of the human genome, since rice has even more genes. 
D) It helped analysis of all genomes, since it was the basis of the ENCODE algorithms. 
A) It was the first genome sequenced, so it proved it could be done. 
B) It sped up the genome analysis of other cereal crops, due to synteny. 
C) It sped up the analysis of the human genome, since rice has even more genes. 
D) It helped analysis of all genomes, since it was the basis of the ENCODE algorithms.

Question 6

Linkage disequilibrium is the tendency for

Accepted Answer

A) be totally randomized during meiosis. 
B) be non-randomly associated during meiosis. 
C) to be rearranged during meiosis because of crossing over. 
D) link together within certain blocks along the chromosome. 
A) be totally randomized during meiosis. 
B) be non-randomly associated during meiosis. 
C) to be rearranged during meiosis because of crossing over. 
D) link together within certain blocks along the chromosome.

Question 7

Distances on a genetic map are measured in _____ units.

Accepted Answer

A) centromere 
B) DNA 
C) dalton 
D) centimorgan 
A) centromere 
B) DNA 
C) dalton 
D) centimorgan

Question 8

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation, which involves

Accepted Answer

A) shotgun cloning. 
B) the alignment of contigs. 
C) the identification of open reading frames. 
D) the construction of a genetic map. 
A) shotgun cloning. 
B) the alignment of contigs. 
C) the identification of open reading frames. 
D) the construction of a genetic map.

Question 9

In vertebrates, the family of myogenic regulatory factors (MRFs) plays a major role in muscle development.This family consists of four related genes which have distinct but overlapping functions.This gene family is represented by only a single gene in Drosophila, called nautilus.You want to know whether nautilus plays a role like all of the MRFs put together, or more like one in particular.What is a quick and easy way to begin to address this question?

Accepted Answer

A) Compare the DNA and protein sequences of all the genes to determine if nautilus is more similar to one MRF than another. 
B) Use a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) Compare the proteome of a cell expressing nautilus to the those of cells expressing each of the MRFs in turn. 
D) Generate four transgenic Drosophila strains that express the MRFs in a mutant nautilus background. 
A) Compare the DNA and protein sequences of all the genes to determine if nautilus is more similar to one MRF than another. 
B) Use a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) Compare the proteome of a cell expressing nautilus to the those of cells expressing each of the MRFs in turn. 
D) Generate four transgenic Drosophila strains that express the MRFs in a mutant nautilus background.

Question 10

The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.

Accepted Answer

A) DNA 
B) genetic 
C) chromosomal 
D) physical 
A) DNA 
B) genetic 
C) chromosomal 
D) physical

Question 11

The best technique for detecting chromosomal abnormalities is

Accepted Answer

A) EST 
B) FISH 
C) STS 
D) SNP 
A) EST 
B) FISH 
C) STS 
D) SNP

Question 12

Given a sequencing reaction length of approximately 500 successive nucleotides, what is the absolute minimum number of sequencing reactions needed to determine the complete human genome, excluding overlap and redundancy?

Accepted Answer

A) 3.1 billion 
B) 6200 
C) 12.4 million 
D) 6.2 million 
A) 3.1 billion 
B) 6200 
C) 12.4 million 
D) 6.2 million

Question 13

The majority of DNA in a human can be described as

Accepted Answer

A) composed of short interspersed elements. 
B) non-coding. 
C) simple sequence repeats. 
D) segmental duplications. 
A) composed of short interspersed elements. 
B) non-coding. 
C) simple sequence repeats. 
D) segmental duplications.

Question 14

The organism with the largest relative genome size is

Accepted Answer

A) rice. 
B) human. 
C) fruit fly. 
D) yeast. 
A) rice. 
B) human. 
C) fruit fly. 
D) yeast.

Question 15

Recombination frequency between genes can be used to generate a

Accepted Answer

A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map. 
A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map.

Question 16

The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called

Accepted Answer

A) shotgun sequencing. 
B) clone-by-clone sequencing. 
C) RFLP sequencing. 
D) consensus sequencing. 
A) shotgun sequencing. 
B) clone-by-clone sequencing. 
C) RFLP sequencing. 
D) consensus sequencing.

Question 17

The inclusive term that describes all of the DNA in the nucleus of a cell is its

Accepted Answer

A) genome. 
B) chromosome. 
C) gene. 
D) proteome. 
A) genome. 
B) chromosome. 
C) gene. 
D) proteome.

Question 18

Non-coding DNA regions within a gene are referred to as

Accepted Answer

A) introns. 
B) exons. 
C) templates. 
D) transposons. 
A) introns. 
B) exons. 
C) templates. 
D) transposons.

Question 19

Silent copies of genes that have been inactivated by mutations are called

Accepted Answer

A) pseudogenes. 
B) clones. 
C) exons. 
D) introns. 
A) pseudogenes. 
B) clones. 
C) exons. 
D) introns.

Question 20

When comparing the actual number of genes, the organism with the highest number is

Accepted Answer

A) rice. 
B) human. 
C) fruit fly. 
D) yeast. 
A) rice. 
B) human. 
C) fruit fly. 
D) yeast.

Exam 18: Genomics

The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they

When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Using actual landmarks within DNA sequences, scientists can generate a _______ map.

How did the rice genome project influence other genome projects?

Linkage disequilibrium is the tendency for

Distances on a genetic map are measured in _____ units.

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation, which involves

The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.

The best technique for detecting chromosomal abnormalities is

Given a sequencing reaction length of approximately 500 successive nucleotides, what is the absolute minimum number of sequencing reactions needed to determine the complete human genome, excluding overlap and redundancy?

The majority of DNA in a human can be described as

The organism with the largest relative genome size is

Recombination frequency between genes can be used to generate a

The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called

The inclusive term that describes all of the DNA in the nucleus of a cell is its

Non-coding DNA regions within a gene are referred to as

Silent copies of genes that have been inactivated by mutations are called

When comparing the actual number of genes, the organism with the highest number is

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