Exam 10: Cell Division and Mitosis

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Vinblastine, a chemotherapeutic drug used to treat breast and testicular cancers, interferes with the assembly of microtubules. Speculate how this drug works to inhibit cancer cell growth. ​

(Multiple Choice)
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    Answer the following questions using the accompanying figure. Figure 10.1 Identify the stage of mitosis shown in panel E. ​   Answer the following questions using the accompanying figure. Figure 10.1 Identify the stage of mitosis shown in panel E. ​

(Multiple Choice)
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Loosely packed regions of DNA associated with histones are called ____. ​

(Multiple Choice)
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Match the cell cycle checkpoint to the correct description. Some choices may be used more than once; some may not be used at all.
Premises:
binding of S cyclin to Cdk2 activates target proteins to overcome the checkpoint for this transition.
Responses:
G1/S checkpoint
G2/M checkpoint
mitotic spindle checkpoint
Correct Answer:
Verified
Premises:
Responses:
binding of S cyclin to Cdk2 activates target proteins to overcome the checkpoint for this transition.
G1/S checkpoint
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The tight packing of chromatin into the chromosomes visible during nuclear division is possible due to links between ____ proteins.

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Comparison of a cancer cell to a normal cell reveals that ____. ​

(Multiple Choice)
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Identify the stage of mitosis at which each of the following activities occurs. Some choices may be used more than once.
Premises:
daughter chromosomes decondense and the nuclear envelope reforms
Responses:
prometaphase
metaphase
anaphase
Correct Answer:
Verified
Premises:
Responses:
daughter chromosomes decondense and the nuclear envelope reforms
prometaphase
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How is cell division different in plants versus animal cells?

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If a given protein's level peaks early in G1, but is absent before the G2 transition, what can be inferred about its possible role in regulating the cell cycle? ​

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A somatic cell divides to form two genetically identical daughter cells during mitosis. Prior to mitosis, what must occur? ​

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Replication of DNA occurs during ____. ​

(Multiple Choice)
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Match the statement to the most appropriate component of cell cycle regulation. Not all choices will be used.
Premises:
activated kinase phosphorylates target proteins, allowing cell division to proceed
Responses:
Cdk/cyclin complex
growth factors
Cdk
Correct Answer:
Verified
Premises:
Responses:
activated kinase phosphorylates target proteins, allowing cell division to proceed
Cdk/cyclin complex
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Humans (which have a chromosome number of 2 n =46)have 92 chromosomes during G2.

(True/False)
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    Answer the following questions using the accompanying figure. Figure 10.1 Identify the stage of mitosis shown in panel A.   Answer the following questions using the accompanying figure. Figure 10.1 Identify the stage of mitosis shown in panel A.

(Multiple Choice)
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Identify the stage of mitosis at which each of the following activities occurs. Some choices may be used more than once.
Premises:
nuclear envelope disappears
Responses:
metaphase
anaphase
prophase
Correct Answer:
Verified
Premises:
Responses:
nuclear envelope disappears
metaphase
(Matching)
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M cyclin binds to Cdk2 in G2, which is required for the progression of the cell through mitosis.

(True/False)
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The microtubule organizing center (MTOC)of an animal cell is an identifiable structure known as the ____.

(Multiple Choice)
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Match the cell cycle checkpoint to the correct description. Some choices may be used more than once; some may not be used at all.
Premises:
Cdk1 phosphorylates target proteins to overcome the checkpoint for this transition
Responses:
mitotic spindle checkpoint
G2/M checkpoint
G1/S checkpoint
Correct Answer:
Verified
Premises:
Responses:
Cdk1 phosphorylates target proteins to overcome the checkpoint for this transition
mitotic spindle checkpoint
(Matching)
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Which external factors influence a cell to divide?

(Essay)
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The evolution of binary fusion solved the mechanical problems associated with distributing long DNA molecules without breakage.

(True/False)
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