Exam 7: The Major Histocompatibility Complex and Antigen Presentation

Examine Figure 7-4.(in the text) Can you summarize, in two sentences maximum, what this figure demonstrates about MHC I-peptide antigen interactions?

A mutation in which part of a viral protein might allow the virus to evade the adaptive immune response because of its MHC binding?

Of the antigen receptors listed here - T-cell receptor, B-cell receptor, MHC I, and MHC II - which would you describe as "promiscuous" in their ligand-binding activity?

Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I.

Which of the following is an example of cross presentation?

In your own words, explain how the immune system can activate CD8⁺ T-cells to eliminate intracellular pathogens (i.e., viruses) unless a dendritic cell happens to become infected.

Name the primary factor contributing to the observation that human genes found within the MHC locus are inherited as a set, which is described by geneticists as a linkage disequilibrium pattern of inheritance.

Which of the following would be the MOST likely source of a peptide bound to an MHC class I molecule?

Your chances of having the same MHC haplotype as your sibling are

MHC polymorphisms tend to cluster

How many different MHC classical class I proteins does each nucleated cell in a human heterozygous at the MHC locus express?

Name an advantage of presenting viral antigens by both the endogenous and exogenous pathways.

Place the class I processing pathway in the correct order:

A mutation that renders the MHC class II molecule DM nonfunctional would likely lead to

Suppose an individual is deficient in TAP (transporter associated with antigen processing).Is the deficiency MORE likely to produce symptoms of immune deficiency or autoimmunity in the person?

One way a developing fetus is protected from attack by the maternal immune system is

Which of the following is the BEST example of self-MHC restriction of T cells?

T-cell activation can be inhibited by treating antigen-presenting cells with chloroquine.What is chloroquine's mechanism of action?

MHC diversity ultimately affects the