Question 1

Which lineage of immune cells constitutes the first line of defense against an infection?

Accepted Answer

A) Lymphoid 
B) Erythroid 
C) Myeloid 
D) All of the answers are correct. 
E) None of the answers are correct. 
A) Lymphoid 
B) Erythroid 
C) Myeloid 
D) All of the answers are correct. 
E) None of the answers are correct.

Question 2

Which of the following cell types secretes IL-17 and may play a role in antifungal responses?

Accepted Answer

A) TH1 
B) TH2 
C) TH17 
D) TFH 
E) Plasma cell 
A) TH1 
B) TH2 
C) TH17 
D) TFH 
E) Plasma cell

Question 3

You have discovered a potentially new leukocyte that appears to share a common progenitor with CD8+ T cells, lack antigen-specific receptors, do not participate in antigen presentation, and have a capacity for ADCC.Using knowledge of hematopoiesis, which cell type MOST closely resembles the potentially new leukocyte?

Accepted Answer

Innate lymphoid cells, which a

Question 4

Which of the following is the pluripotent stem cell that gives rise to all blood cells?

Accepted Answer

A) CLP 
B) CMP 
C) CEP 
D) HSC 
E) None of the answers are correct. 
A) CLP 
B) CMP 
C) CEP 
D) HSC 
E) None of the answers are correct.

Question 5

Which of the following types of effector T lymphocytes is capable of inhibiting an immune response to an antigen recognized with its T-cell receptor (TCR)?

Accepted Answer

A) TH1 
B) TREG 
C) TH2 
D) TH17 
E) None of the answers are correct. 
A) TH1 
B) TREG 
C) TH2 
D) TH17 
E) None of the answers are correct.

Question 6

From which of the following stem cells are helper T cells (TH) derived?

Accepted Answer

A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct. 
A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct.

Question 7

Which properties listed below are shared by both naïve B cells and mature T cells?

Accepted Answer

A) Are derived from lymphoid progenitor cells 
B) Are considered lymphocytes 
C) Contain membrane-bound antigen receptors 
D) All of the answers are correct. 
E) None of the answers are correct. 
A) Are derived from lymphoid progenitor cells 
B) Are considered lymphocytes 
C) Contain membrane-bound antigen receptors 
D) All of the answers are correct. 
E) None of the answers are correct.

Question 8

Contraction of which of the following types of muscles is responsible for propulsion of lymph through the lymphatic system?

Accepted Answer

A) Cardiac 
B) Skeletal 
C) Smooth 
D) Both skeletal and smooth are correct. 
E) None of the answers are correct. 
A) Cardiac 
B) Skeletal 
C) Smooth 
D) Both skeletal and smooth are correct. 
E) None of the answers are correct.

Question 9

If a human were unable to produce lymphoid progenitor cells, predict which part of the immune system would be MOST greatly impacted?

Accepted Answer

A) Innate immunity 
B) Adaptive immunity 
C) Both innate and adaptive would be equally impacted 
D) Neither innate nor adaptive immunity would be impacted 
E) None of the answers would be impacted. 
A) Innate immunity 
B) Adaptive immunity 
C) Both innate and adaptive would be equally impacted 
D) Neither innate nor adaptive immunity would be impacted 
E) None of the answers would be impacted.

Question 10

Which of the following cell types is responsible for the secretion of immunoglobulins?

Accepted Answer

A) TH1 
B) TH2 
C) TH17 
D) TFH 
E) Plasma cell 
A) TH1 
B) TH2 
C) TH17 
D) TFH 
E) Plasma cell

Question 11

In addition to the bone marrow, HSCs have been observed to occur within the blood.How has this observation improved the procedures used to transplant HSCs from donors to recipients that are bone marrow deficient?

Accepted Answer

In some cases, it is now possi

Question 12

A graduate student observes a strain of mice that are impaired in their ability to combat parasitic worms.Given this observation, which arm of hematopoiesis is MOST likely deficient in this strain?

Accepted Answer

The myeloid arm of hematopoies

Question 13

Imagine that you are a thymocyte that has just entered the thymus.Assuming you will survive positive and negative selection, what changes will you experience before developing in a naïve CD4+ T cell?

Accepted Answer

The thymocyte would change fro

Question 14

In your own words, explain how an NKT cell displays properties of both innate and adaptive immunity.

Accepted Answer

NKT cells have TCRs, yet also

Question 15

Using a light microscope, you observe a human blood smear.Among the abundance of erythrocytes, you note a leukocyte that appears to contain a multilobed nucleus.What is the MOST likely identity of the observed leukocyte?

Accepted Answer

A) T lymphocyte 
B) B lymphocyte 
C) Neutrophil 
D) Eosinophil 
E) Both Neutrophil and eosinophil are equally likely. 
A) T lymphocyte 
B) B lymphocyte 
C) Neutrophil 
D) Eosinophil 
E) Both Neutrophil and eosinophil are equally likely.

Question 16

Can you think of two cellular activities occurring within a swelling lymph node that has been exposed to antigen from a pathogen?

Accepted Answer

Immune cells are actively migrating into

Question 17

From which of the following stem cells are DCs derived?

Accepted Answer

A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct. 
A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct.

Question 18

In mammals, T-cell development occurs in the _____, whereas B-cell development occurs predominantly in the _____.

Accepted Answer

A) thymus; bursa of Fabricius 
B) bone marrow; mesenteric lymph nodes 
C) bone marrow; thymus 
D) thymus; bone marrow 
E) None of the answers are correct. 
A) thymus; bursa of Fabricius 
B) bone marrow; mesenteric lymph nodes 
C) bone marrow; thymus 
D) thymus; bone marrow 
E) None of the answers are correct.

Question 19

From which of the following stem cells are platelets derived?

Accepted Answer

A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct. 
A) CLP 
B) CMP 
C) CEP 
D) Both CLP and CMP. 
E) None of the answers are correct.

Question 20

All blood cells in an adult human can trace their ancestry to which compartment within the body?

Accepted Answer

A) Thymus 
B) Bone marrow 
C) Lymph node 
D) Peyer's patch 
E) None of the answers are correct. 
A) Thymus 
B) Bone marrow 
C) Lymph node 
D) Peyer's patch 
E) None of the answers are correct.

Which lineage of immune cells constitutes the first line of defense against an infection?

Which of the following cell types secretes IL-17 and may play a role in antifungal responses?

Which of the following is the pluripotent stem cell that gives rise to all blood cells?

Which of the following types of effector T lymphocytes is capable of inhibiting an immune response to an antigen recognized with its T-cell receptor (TCR)?

From which of the following stem cells are helper T cells (T_H) derived?

Which properties listed below are shared by both naïve B cells and mature T cells?

Contraction of which of the following types of muscles is responsible for propulsion of lymph through the lymphatic system?

If a human were unable to produce lymphoid progenitor cells, predict which part of the immune system would be MOST greatly impacted?

Which of the following cell types is responsible for the secretion of immunoglobulins?

In addition to the bone marrow, HSCs have been observed to occur within the blood.How has this observation improved the procedures used to transplant HSCs from donors to recipients that are bone marrow deficient?

A graduate student observes a strain of mice that are impaired in their ability to combat parasitic worms.Given this observation, which arm of hematopoiesis is MOST likely deficient in this strain?

Imagine that you are a thymocyte that has just entered the thymus.Assuming you will survive positive and negative selection, what changes will you experience before developing in a naïve CD4⁺ T cell?

In your own words, explain how an NKT cell displays properties of both innate and adaptive immunity.

Using a light microscope, you observe a human blood smear.Among the abundance of erythrocytes, you note a leukocyte that appears to contain a multilobed nucleus.What is the MOST likely identity of the observed leukocyte?

Can you think of two cellular activities occurring within a swelling lymph node that has been exposed to antigen from a pathogen?

From which of the following stem cells are DCs derived?

In mammals, T-cell development occurs in the _, whereas B-cell development occurs predominantly in the _.

From which of the following stem cells are platelets derived?

All blood cells in an adult human can trace their ancestry to which compartment within the body?

Overview of the Immune System

Recognition and Response

Innate Immunity

The Complement System

The Organization and Expression of Lymphocyte Receptor Genes

The Major Histocompatibility Complex and Antigen Presentation

T-Cell Development

B-Cell Development

T-Cell Activation, Differentiation, and Memory

B-Cell Activation, Differentiation, and Memory

Effector Responses: Cell- and Antibody-Mediated Immunity

Mucosal Immunity and the Microbiome

The Immune Response in Time and Space

Allergy, Hypersensitivities, and Chronic Inflammation

Tolerance, Autoimmunity, and Transplantation

Infectious Diseases and Vaccines

Immunodeficiency Disorders

Cancer and the Immune System

Experimental Methods and Systems

Filters

Exam 2: Cells, Organs, and Microenvironments of the Immune System

Which lineage of immune cells constitutes the first line of defense against an infection?

Which of the following cell types secretes IL-17 and may play a role in antifungal responses?

Which of the following is the pluripotent stem cell that gives rise to all blood cells?

Which of the following types of effector T lymphocytes is capable of inhibiting an immune response to an antigen recognized with its T-cell receptor (TCR)?

From which of the following stem cells are helper T cells (TH) derived?

Which properties listed below are shared by both naïve B cells and mature T cells?

Contraction of which of the following types of muscles is responsible for propulsion of lymph through the lymphatic system?

If a human were unable to produce lymphoid progenitor cells, predict which part of the immune system would be MOST greatly impacted?

Which of the following cell types is responsible for the secretion of immunoglobulins?

In addition to the bone marrow, HSCs have been observed to occur within the blood.How has this observation improved the procedures used to transplant HSCs from donors to recipients that are bone marrow deficient?

A graduate student observes a strain of mice that are impaired in their ability to combat parasitic worms.Given this observation, which arm of hematopoiesis is MOST likely deficient in this strain?

Imagine that you are a thymocyte that has just entered the thymus.Assuming you will survive positive and negative selection, what changes will you experience before developing in a naïve CD4+ T cell?

In your own words, explain how an NKT cell displays properties of both innate and adaptive immunity.

Using a light microscope, you observe a human blood smear.Among the abundance of erythrocytes, you note a leukocyte that appears to contain a multilobed nucleus.What is the MOST likely identity of the observed leukocyte?

Can you think of two cellular activities occurring within a swelling lymph node that has been exposed to antigen from a pathogen?

From which of the following stem cells are DCs derived?

In mammals, T-cell development occurs in the _____, whereas B-cell development occurs predominantly in the _____.

From which of the following stem cells are platelets derived?

All blood cells in an adult human can trace their ancestry to which compartment within the body?

Overview of the Immune System

Recognition and Response

Innate Immunity

The Complement System

The Organization and Expression of Lymphocyte Receptor Genes

The Major Histocompatibility Complex and Antigen Presentation

T-Cell Development

B-Cell Development

T-Cell Activation, Differentiation, and Memory

B-Cell Activation, Differentiation, and Memory

Effector Responses: Cell- and Antibody-Mediated Immunity

Mucosal Immunity and the Microbiome

The Immune Response in Time and Space

Allergy, Hypersensitivities, and Chronic Inflammation

Tolerance, Autoimmunity, and Transplantation

Infectious Diseases and Vaccines

Immunodeficiency Disorders

Cancer and the Immune System

Experimental Methods and Systems

Filters

From which of the following stem cells are helper T cells (T_H) derived?

Imagine that you are a thymocyte that has just entered the thymus.Assuming you will survive positive and negative selection, what changes will you experience before developing in a naïve CD4⁺ T cell?

In mammals, T-cell development occurs in the _, whereas B-cell development occurs predominantly in the _.