Question 1

B lymphocytes are made in the

Accepted Answer

A) blood stream. 
B) bone marrow. 
C) liver. 
D) thymus. 
E) totipotent cell. 
A) blood stream. 
B) bone marrow. 
C) liver. 
D) thymus. 
E) totipotent cell.

Question 2

Which of the following statements regarding HSCs is/are TRUE?
I.HSCs are not self-renewing.
II.HSCs can make copies of themselves.
III.HSCs give rise to one cell lineage.
IV.HSCs are multipotent.
V.HSCs express both RAG1 and RAG2 surface markers.

Accepted Answer

A) Statement I only 
B) Statements I and III only 
C) Statements II and III only 
D) Statements II and IV only 
E) Statements III and V only 
A) Statement I only 
B) Statements I and III only 
C) Statements II and III only 
D) Statements II and IV only 
E) Statements III and V only

Question 3

Recent experiments have focused on identifying differences between signal transduction events leading to B-cell activation versus B-cell anergy.As a new tutor for immunology, how would you summarize these recent experiments to a student client?

Accepted Answer

Anergic B cells show less antigen-induce

Question 4

All of the following are true regarding B-cell development EXCEPT

Accepted Answer

A) B cells complete maturation in the spleen. 
B) B cells are mostly developed when they leave the bone marrow. 
C) B cells, like T cells, are MHC class restricted. 
D) Self-reactive B cells may be eliminated though apoptosis. 
E) Self-reactive B cells may be rendered unreactive (anergic). 
A) B cells complete maturation in the spleen. 
B) B cells are mostly developed when they leave the bone marrow. 
C) B cells, like T cells, are MHC class restricted. 
D) Self-reactive B cells may be eliminated though apoptosis. 
E) Self-reactive B cells may be rendered unreactive (anergic).

Question 5

Transgenic animals that fail to express a BCR during the immature B-cell stages lose the capacity to produce any B cells at all.What does this observation indicate?

Accepted Answer

The observation indicates that

Question 6

What is the initial location of B-cell and T-cell development?

Accepted Answer

A) Blood for B cell and thymus for T cell 
B) Bone marrow for both B cell and T cell 
C) Bone marrow for B cell and thymus for T cell 
D) Secondary lymphoid organs for B cell and thymus for T cell 
E) Thymus for both B cell and T cell 
A) Blood for B cell and thymus for T cell 
B) Bone marrow for both B cell and T cell 
C) Bone marrow for B cell and thymus for T cell 
D) Secondary lymphoid organs for B cell and thymus for T cell 
E) Thymus for both B cell and T cell

Question 7

Of the cells listed below, which one represents the MOST developed B cell?

Accepted Answer

A) Pre-pro-B cell 
B) Pro-B cell 
C) Pre-B cell 
D) T1 B cells 
E) T2 B cells 
A) Pre-pro-B cell 
B) Pro-B cell 
C) Pre-B cell 
D) T1 B cells 
E) T2 B cells

Question 8

V-DJ recombination occurs during which phase of a B cell's development?

Accepted Answer

A) Activated B cell 
B) Mature B cell 
C) Naïve B cell 
D) Pro-B cell 
E) Immature B cell 
A) Activated B cell 
B) Mature B cell 
C) Naïve B cell 
D) Pro-B cell 
E) Immature B cell

Question 9

Mature naïve B cells express high levels of _____ on their cell surfaces.

Accepted Answer

A) IgA 
B) IgD 
C) IgE 
D) IgG 
E) IgM 
A) IgA 
B) IgD 
C) IgE 
D) IgG 
E) IgM

Question 10

Which cell type is found in both B- and T-cell lineages?

Accepted Answer

A) Common lymphoid progenitors 
B) Common pro-B-T cells 
C) Immature B cell 
D) Naïve lymphoid progenitor 
E) Pro-B-T cell 
A) Common lymphoid progenitors 
B) Common pro-B-T cells 
C) Immature B cell 
D) Naïve lymphoid progenitor 
E) Pro-B-T cell

Question 11

This type of cell will leave the bone marrow and complete maturation in the spleen.

Accepted Answer

A) Common lymphoid progenitor cell 
B) Hematopoietic stem cell 
C) Immature B cell 
D) Pro-B cell 
E) Pro-T cell 
A) Common lymphoid progenitor cell 
B) Hematopoietic stem cell 
C) Immature B cell 
D) Pro-B cell 
E) Pro-T cell

Question 12

Individuals of retirement age or older show lower antibody mediate immune responses due to all the following reasons EXCEPT

Accepted Answer

A) increased likelihood of autoimmune disorders. 
B) limited HSC production of pro-B cells. 
C) poor antibody response to vaccination. 
D) reduced-memory B-cell generation. 
E) smaller thymus. 
A) increased likelihood of autoimmune disorders. 
B) limited HSC production of pro-B cells. 
C) poor antibody response to vaccination. 
D) reduced-memory B-cell generation. 
E) smaller thymus.

Question 13

Mature B-2 or follicular B cells are most commonly found in the

Accepted Answer

A) bone marrow. 
B) lymph node. 
C) marginal zones of the spleen. 
D) peritoneal. 
E) secondary lymphoid organs. 
A) bone marrow. 
B) lymph node. 
C) marginal zones of the spleen. 
D) peritoneal. 
E) secondary lymphoid organs.

Question 14

At what site(s) can mature HSCs be found by day 11 in the mouse model?

Accepted Answer

A) AGM 
B) Fetal liver 
C) Placenta 
D) Yolk 
E) All of the answers are correct. 
A) AGM 
B) Fetal liver 
C) Placenta 
D) Yolk 
E) All of the answers are correct.

Question 15

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Accepted Answer

A) Pre-pro-B cell 
B) Early pro-B cell 
C) Late pro-B cell 
D) Late pre-B cell 
E) Immature B cell 
A) Pre-pro-B cell 
B) Early pro-B cell 
C) Late pro-B cell 
D) Late pre-B cell 
E) Immature B cell

Question 16

Marginal-zone B cells express

Accepted Answer

A) IgD. 
B) IgG. 
C) IgM. 
D) IgE. 
E) Both IgG and IgM are correct. 
A) IgD. 
B) IgG. 
C) IgM. 
D) IgE. 
E) Both IgG and IgM are correct.

Question 17

Which molecule listed below appears to play a critical role in trafficking B cells from the bone marrow to the spleen to complete cellular maturation?

Accepted Answer

A) SCF 
B) S1P 
C) IL-7 
D) BIM 
E) Both SCF and S1P are correct. 
A) SCF 
B) S1P 
C) IL-7 
D) BIM 
E) Both SCF and S1P are correct.

Question 18

Immature B cells in the bone marrow that are found to bear self-antigen reactive BCRs undergo which of the following?

Accepted Answer

A) Clonal deletion 
B) Light chain receptor editing 
C) Development of anergy 
D) All of the answers are correct. 
E) None of the answers are correct. 
A) Clonal deletion 
B) Light chain receptor editing 
C) Development of anergy 
D) All of the answers are correct. 
E) None of the answers are correct.

Question 19

Hematopoiesis begins at around day 7 after fertilization in mice.What is the site of precursor cells at this stage of fetal development?

Accepted Answer

A) Bone marrow 
B) Fetal liver 
C) Placenta 
D) Primitive organ 
E) Yolk sac 
A) Bone marrow 
B) Fetal liver 
C) Placenta 
D) Primitive organ 
E) Yolk sac

Question 20

The common lymphoid progenitor cell gives rise to all the following cell lines EXCEPT

Accepted Answer

A) dendritic cells. 
B) megakaryocytes. 
C) natural killer cells. 
D) pre-pro B cells. 
E) T-cell progenitor. 
A) dendritic cells. 
B) megakaryocytes. 
C) natural killer cells. 
D) pre-pro B cells. 
E) T-cell progenitor.

B lymphocytes are made in the

Which of the following statements regarding HSCs is/are TRUE? I.HSCs are not self-renewing. II.HSCs can make copies of themselves. III.HSCs give rise to one cell lineage. IV.HSCs are multipotent. V.HSCs express both RAG1 and RAG2 surface markers.

Recent experiments have focused on identifying differences between signal transduction events leading to B-cell activation versus B-cell anergy.As a new tutor for immunology, how would you summarize these recent experiments to a student client?

All of the following are true regarding B-cell development EXCEPT

Transgenic animals that fail to express a BCR during the immature B-cell stages lose the capacity to produce any B cells at all.What does this observation indicate?

What is the initial location of B-cell and T-cell development?

Of the cells listed below, which one represents the MOST developed B cell?

V-DJ recombination occurs during which phase of a B cell's development?

Mature naïve B cells express high levels of _____ on their cell surfaces.

Which cell type is found in both B- and T-cell lineages?

This type of cell will leave the bone marrow and complete maturation in the spleen.

Individuals of retirement age or older show lower antibody mediate immune responses due to all the following reasons EXCEPT

Mature B-2 or follicular B cells are most commonly found in the

At what site(s) can mature HSCs be found by day 11 in the mouse model?

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful V_H-DJ_H combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Marginal-zone B cells express

Which molecule listed below appears to play a critical role in trafficking B cells from the bone marrow to the spleen to complete cellular maturation?

Immature B cells in the bone marrow that are found to bear self-antigen reactive BCRs undergo which of the following?

Hematopoiesis begins at around day 7 after fertilization in mice.What is the site of precursor cells at this stage of fetal development?

The common lymphoid progenitor cell gives rise to all the following cell lines EXCEPT

Overview of the Immune System

Cells, Organs, and Microenvironments of the Immune System

Recognition and Response

Innate Immunity

The Complement System

The Organization and Expression of Lymphocyte Receptor Genes

The Major Histocompatibility Complex and Antigen Presentation

T-Cell Development

T-Cell Activation, Differentiation, and Memory

B-Cell Activation, Differentiation, and Memory

Effector Responses: Cell- and Antibody-Mediated Immunity

Mucosal Immunity and the Microbiome

The Immune Response in Time and Space

Allergy, Hypersensitivities, and Chronic Inflammation

Tolerance, Autoimmunity, and Transplantation

Infectious Diseases and Vaccines

Immunodeficiency Disorders

Cancer and the Immune System

Experimental Methods and Systems

Filters

Exam 9: B-Cell Development

B lymphocytes are made in the

Which of the following statements regarding HSCs is/are TRUE? I.HSCs are not self-renewing. II.HSCs can make copies of themselves. III.HSCs give rise to one cell lineage. IV.HSCs are multipotent. V.HSCs express both RAG1 and RAG2 surface markers.

Recent experiments have focused on identifying differences between signal transduction events leading to B-cell activation versus B-cell anergy.As a new tutor for immunology, how would you summarize these recent experiments to a student client?

All of the following are true regarding B-cell development EXCEPT

Transgenic animals that fail to express a BCR during the immature B-cell stages lose the capacity to produce any B cells at all.What does this observation indicate?

What is the initial location of B-cell and T-cell development?

Of the cells listed below, which one represents the MOST developed B cell?

V-DJ recombination occurs during which phase of a B cell's development?

Mature naïve B cells express high levels of _____ on their cell surfaces.

Which cell type is found in both B- and T-cell lineages?

This type of cell will leave the bone marrow and complete maturation in the spleen.

Individuals of retirement age or older show lower antibody mediate immune responses due to all the following reasons EXCEPT

Mature B-2 or follicular B cells are most commonly found in the

At what site(s) can mature HSCs be found by day 11 in the mouse model?

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?

Marginal-zone B cells express

Which molecule listed below appears to play a critical role in trafficking B cells from the bone marrow to the spleen to complete cellular maturation?

Immature B cells in the bone marrow that are found to bear self-antigen reactive BCRs undergo which of the following?

Hematopoiesis begins at around day 7 after fertilization in mice.What is the site of precursor cells at this stage of fetal development?

The common lymphoid progenitor cell gives rise to all the following cell lines EXCEPT

Overview of the Immune System

Cells, Organs, and Microenvironments of the Immune System

Recognition and Response

Innate Immunity

The Complement System

The Organization and Expression of Lymphocyte Receptor Genes

The Major Histocompatibility Complex and Antigen Presentation

T-Cell Development

T-Cell Activation, Differentiation, and Memory

B-Cell Activation, Differentiation, and Memory

Effector Responses: Cell- and Antibody-Mediated Immunity

Mucosal Immunity and the Microbiome

The Immune Response in Time and Space

Allergy, Hypersensitivities, and Chronic Inflammation

Tolerance, Autoimmunity, and Transplantation

Infectious Diseases and Vaccines

Immunodeficiency Disorders

Cancer and the Immune System

Experimental Methods and Systems

Filters

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful V_H-DJ_H combination that does not recognize self.If no successful combination is produced, then the B cell will undergo apoptosis.At what point of B-cell development does this checkpoint occur?