Question 1

The working draft of the human genome reported that the genome contains approximately how many genes?

Accepted Answer

A) less than 1,000 
B) 2,000 
C) 5,000 
D) 10,000 
E) 20,000 
A) less than 1,000 
B) 2,000 
C) 5,000 
D) 10,000 
E) 20,000 E

Question 2

The number of genes in the human genome appears to be a lot less than expected.One way for a cell to express multiple proteins from one gene is by_________________.

Accepted Answer

alternate splicing

Question 3

Using M.genitalium,Ventor and colleagues have shown that the essential gene set for life is the same size as the minimal genome to sustain a cell.

Accepted Answer

A) True 
 B)False  False

Question 4

In the context of genetic mapping,mapping depends on a set of landmarks to which the position of a gene can be related.Sometimes the landmarks are genes but more often they are RFLPs.

Accepted Answer

A) True 
 B)False

Question 5

Which of the following types of genetic markers tend to bunch together at the ends of chromosomes?

Accepted Answer

A) VNTRs 
B) a class of STSs called microsatellites 
C) STSs 
D) RFLPs 
E) none of the above 
A) VNTRs 
B) a class of STSs called microsatellites 
C) STSs 
D) RFLPs 
E) none of the above

Question 6

One of the first steps in the Clone-by-Clone strategy is to map the genome using chromosomal markers.Which of the following is not a marker used to map a genome?

Accepted Answer

A) YACs 
B) RFLPs 
C) VNTRs 
D) STSs 
E) ESTs 
A) YACs 
B) RFLPs 
C) VNTRs 
D) STSs 
E) ESTs

Question 7

Which of the following is not a finding from analysis of the complete DNA sequence of human chromosome 22?

Accepted Answer

A) It contains 679 annotated genes. 
B) It contains local and long range duplications. 
C) It contains orthologs to the mouse chromosome. 
D) It contains very little noncoding DNA. 
E) It contains "poison regions" or gaps that may never get sequenced. 
A) It contains 679 annotated genes. 
B) It contains local and long range duplications. 
C) It contains orthologs to the mouse chromosome. 
D) It contains very little noncoding DNA. 
E) It contains "poison regions" or gaps that may never get sequenced.

Question 8

The estimated total number of genes in the human genome is

Accepted Answer

A) 10,000-15,000. 
B) 20,000-25,000. 
C) 40,000-50,000. 
D) 50,000-75,000. 
E) 100,000-130,000. 
A) 10,000-15,000. 
B) 20,000-25,000. 
C) 40,000-50,000. 
D) 50,000-75,000. 
E) 100,000-130,000.

Question 9

A gene-finding technique exists that takes advantage of the fact that control regions of active human genes tend to be associated with unmethylated CpG sequences,compared to the CpGs in inactive regions that are almost always methylated.

Accepted Answer

A) True 
 B)False

Question 10

A gene's coding region between the start and stop codons is referred to as a(n)___________.

Accepted Answer

The answer of A gene's coding region between the start...

Question 11

BAC vectors are based on the E.coli F plasmid,which is normally used by the bacteria for ________________.

Accepted Answer

The answer of BAC vectors are based on the E.coli...

Question 12

The fact that the genomes of two different individuals will produce fragments of different lengths when cut with restriction enzymes is called____________.

Accepted Answer

restrictio

Question 13

An _____________ is a sequence of bases that,if translated in one reading frame,contains no stop codons for a relatively long distance.

Accepted Answer

open readi

Question 14

The process by which a library of clones with different size inserts is first DNA sequenced and then a computer is used to piece the DNA sequences together is called________.

Accepted Answer

The answer of The process by which a library of...

Question 15

Comparison of the genomes of humans and our closest living relative,the chimpanzee,has identified a few DNA regions that have changed rapidly since the two species diverged.Which statement below accurately depicts the thing that sets humans apart from chimpanzees.

Accepted Answer

A) the few regions that have rapidly changed are all protein-encoding genes 
B) humans have been found to have many more genes than chimpanzees 
C) chimpanzees have been found to have many more non-coding regions in their genome 
D) the control of the genes,rather than the genes themselves are what sets humans apart from chimpanzees 
E) all of the above 
A) the few regions that have rapidly changed are all protein-encoding genes 
B) humans have been found to have many more genes than chimpanzees 
C) chimpanzees have been found to have many more non-coding regions in their genome 
D) the control of the genes,rather than the genes themselves are what sets humans apart from chimpanzees 
E) all of the above

Question 16

Which of the following processes was used to locate the gene responsible for Huntington disease?

Accepted Answer

A) shot-gun cloning 
B) positional cloning 
C) genome sequencing 
D) SAGE 
E) proteomics 
A) shot-gun cloning 
B) positional cloning 
C) genome sequencing 
D) SAGE 
E) proteomics

Question 17

The control regions of actively transcribed genes usually contain methylated CpG islands.

Accepted Answer

A) True 
 B)False

Question 18

In 2010,Venter and colleagues introduced an entirely synthetic M.mycoides genome into M.capricolum cells.The success of this experiment ushered in a new era of ?

Accepted Answer

The answer of In 2010,Venter and colleagues introduced an entirely...

Question 19

Which of the following free living organisms has the smallest genome,containing about only 470 genes?

Accepted Answer

A) Haemophilus influenzae Rd 
B) Mycoplasma genitalium 
C) Methanococcus jannaschii 
D) Saccharomyces cerevisiae 
E) Caenorhabditis elegans 
A) Haemophilus influenzae Rd 
B) Mycoplasma genitalium 
C) Methanococcus jannaschii 
D) Saccharomyces cerevisiae 
E) Caenorhabditis elegans

Question 20

Genome size is a good indication of the number of genes it contains,the larger the genome the greater the number of genes.

Accepted Answer

A) True 
 B)False

Exam 24: Introduction to Genomics: Dna Sequencing on a Genomic Scale

The working draft of the human genome reported that the genome contains approximately how many genes?

The number of genes in the human genome appears to be a lot less than expected.One way for a cell to express multiple proteins from one gene is by_________________.

Using M.genitalium,Ventor and colleagues have shown that the essential gene set for life is the same size as the minimal genome to sustain a cell.

In the context of genetic mapping,mapping depends on a set of landmarks to which the position of a gene can be related.Sometimes the landmarks are genes but more often they are RFLPs.

Which of the following types of genetic markers tend to bunch together at the ends of chromosomes?

One of the first steps in the Clone-by-Clone strategy is to map the genome using chromosomal markers.Which of the following is not a marker used to map a genome?

Which of the following is not a finding from analysis of the complete DNA sequence of human chromosome 22?

The estimated total number of genes in the human genome is

A gene-finding technique exists that takes advantage of the fact that control regions of active human genes tend to be associated with unmethylated CpG sequences,compared to the CpGs in inactive regions that are almost always methylated.

A gene's coding region between the start and stop codons is referred to as a(n)___________.

BAC vectors are based on the E.coli F plasmid,which is normally used by the bacteria for ________________.

The fact that the genomes of two different individuals will produce fragments of different lengths when cut with restriction enzymes is called____________.

An _____________ is a sequence of bases that,if translated in one reading frame,contains no stop codons for a relatively long distance.

The process by which a library of clones with different size inserts is first DNA sequenced and then a computer is used to piece the DNA sequences together is called________.

Comparison of the genomes of humans and our closest living relative,the chimpanzee,has identified a few DNA regions that have changed rapidly since the two species diverged.Which statement below accurately depicts the thing that sets humans apart from chimpanzees.

Which of the following processes was used to locate the gene responsible for Huntington disease?

The control regions of actively transcribed genes usually contain methylated CpG islands.

In 2010,Venter and colleagues introduced an entirely synthetic M.mycoides genome into M.capricolum cells.The success of this experiment ushered in a new era of ?

Which of the following free living organisms has the smallest genome,containing about only 470 genes?

Genome size is a good indication of the number of genes it contains,the larger the genome the greater the number of genes.

A Brief History

The Molecular Nature of Genes

An Introduction to Gene Function

Molecular Cloning Methods

Molecular Tools for Studying Genes and Gene Activity

The Mechanism of Transcription in Bacteria

Operons: Fine Control of Bacterial Transcription

Major Shifts in Bacterial Transcription

Dna-Protein Interactions in Bacteria

Eukaryotic Rna Polymerases and Their Promoters

General Transcription Factors in Eukaryotes

Transcription Activators in Eukaryotes

Chromatin Structure and Its Effect on Transcription

Rna Processing I: Splicing

Rna Processing II: Capping and Polyadenylation

Rna Processing: Other Post-Transcriptional Events

The Mechanism of Translation I: Initiation

The Mechanism of Translation II: Elongation and Termination

Ribosomes and Transfer Rna

Dna Replication,damage and Repair

Dna Replication II: Detailed Mechanism

Homologous Recombination

Transposition

Genomics II: Functional Genomics,proteomics and Bioinformatics

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