Exam 24: Introduction to Genomics: Dna Sequencing on a Genomic Scale

Geneticists have discovered a class of STSs called ____________ that are highly polymorphic and useful as genetic markers in genetic mapping.

Transposons don't appear to have played a role in the evolution of the human genome.

BAC cloning vectors are much more useful than the pUC cloning vectors for genome sequencing because they can accept larger DNA fragments.

Which of the following enzymes is used to search for CpG islands?

Using RFLP geneticists were able to map the gene for Huntington disease to a region near the end of human chromosome ________.

_________ are homologous genes that have evolved from gene duplication within a species.

Positional cloning begins with mapping studies to pin down the location of the gene of interest to a reasonable small region of DNA.

Radiation hybrid mapping involves irradiation of human cells to break the chromosomes,then fusion of the dead cells with hamster cells to form hybrid cells.The further apart two markers are on a chromosome the more likely they will be found in two different hybrids.

Huntington disease is controlled by a single gene having a mutated dominant allele.