Question 1

Which genetic disease has been linked to a mutation of the tumor-suppressor gene?

Accepted Answer

A) Hemochromatosis 
B) Retinoblastoma 
C) Familial breast cancer 
D) Hemophilia A 
A) Hemochromatosis 
B) Retinoblastoma 
C) Familial breast cancer 
D) Hemophilia A B

Question 2

Chromosome abnormalities are the leading cause of mental retardation and miscarriage.

Accepted Answer

A) True 
 B)False  True

Question 3

Match the genetic terms with the corresponding diseases. Terms may be used more than once.
-Hemophilia

Accepted Answer

A) Autosomal dominant 
B) Autosomal recessive 
C) X-linked dominant 
D) X-linked recessive 
A) Autosomal dominant 
B) Autosomal recessive 
C) X-linked dominant 
D) X-linked recessive D

Question 4

A person with XXXY has the genetic disorder called __________ syndrome.

Accepted Answer

A) Turner 
B) Klinefelter 
C) Down 
D) Fragile X 
A) Turner 
B) Klinefelter 
C) Down 
D) Fragile X

Question 5

Inserting bone marrow cells into an individual who produces abnormal erythrocytes is an example of _____ therapy.

Accepted Answer

A) somatic cell 
B) germ cell 
C) genetic engineering 
D) recombinant DNA 
A) somatic cell 
B) germ cell 
C) genetic engineering 
D) recombinant DNA

Question 6

Match the disease with its chromosomal abnormality.
-An additional chromosome joining the normal homologous pair

Accepted Answer

A) Down syndrome 
B) Klinefelter syndrome 
C) Turner syndrome 
D) Cri du chat 
A) Down syndrome 
B) Klinefelter syndrome 
C) Turner syndrome 
D) Cri du chat

Question 7

Which of the following disorders has a mode of inheritance similar to hemophilia A?

Accepted Answer

A) Cri du chat syndrome 
B) Duchenne muscular dystrophy (DM
D)  
C) Polycystic kidney disease 
D) Down syndrome 
A) Cri du chat syndrome 
B) Duchenne muscular dystrophy (DM
D)  
C) Polycystic kidney disease 
D) Down syndrome

Question 8

RNA polymerase is the most important protein in DNA replication.

Accepted Answer

A) True 
 B)False

Question 9

Match the disease with its chromosomal abnormality.
-Single X chromosome with no homologous X or Y chromosome

Accepted Answer

A) Down syndrome 
B) Klinefelter syndrome 
C) Turner syndrome 
D) Cri du chat 
A) Down syndrome 
B) Klinefelter syndrome 
C) Turner syndrome 
D) Cri du chat

Question 10

In most cases of recessive disease, both parents of affected individuals are heterozygous carriers.

Accepted Answer

A) True 
 B)False

Question 11

What is the diagnosis of a 13-year-old female who has a karyotype that reveals an absent homologous X chromosome with only a single X chromosome present with features that include a short stature, widely spaced nipples, reduced carrying angle at the elbow, and sparse body hair?

Accepted Answer

A) Down syndrome 
B) Cri du chat syndrome 
C) Turner syndrome 
D) Klinefelter syndrome 
A) Down syndrome 
B) Cri du chat syndrome 
C) Turner syndrome 
D) Klinefelter syndrome

Question 12

Match the genetic terms with the corresponding diseases. Terms may be used more than once.
-Cystic fibrosis

Accepted Answer

A) Autosomal dominant 
B) Autosomal recessive 
C) X-linked dominant 
D) X-linked recessive 
A) Autosomal dominant 
B) Autosomal recessive 
C) X-linked dominant 
D) X-linked recessive

Question 13

DNA formation and protein synthesis occur in the cell nucleus.

Accepted Answer

A) True 
 B)False

Question 14

Which is an important criterion for discerning autosomal recessive inheritance?

Accepted Answer

A) Consanguinity is often present. 
B) Females are affected more than males. 
C) The disease is seen in the parents and in the siblings. 
D) On average, one half of the offspring of the carrier will be affected. 
A) Consanguinity is often present. 
B) Females are affected more than males. 
C) The disease is seen in the parents and in the siblings. 
D) On average, one half of the offspring of the carrier will be affected.

Question 15

What is the second most commonly recognized genetic cause of mental retardation?

Accepted Answer

A) Down syndrome 
B) Fragile X syndrome 
C) Klinefelter syndrome 
D) Turner syndrome 
A) Down syndrome 
B) Fragile X syndrome 
C) Klinefelter syndrome 
D) Turner syndrome

Question 16

A couple has two children with a genetic disease.What is the probability that the next child will have the same genetic disease?

Accepted Answer

A) One sixth 
B) One fourth 
C) One third 
D) One half 
A) One sixth 
B) One fourth 
C) One third 
D) One half

Question 17

The purpose of a staining technique of chromosomes such as Giemsa is to:

Accepted Answer

A) allow the mitotic process to be followed and monitored for variations. 
B) allow the numbering of chromosomes and identification of variations. 
C) identify new somatic cells formed through mitosis and cytokinesis. 
D) distinguish the sex chromosome from the homologous chromosomes. 
A) allow the mitotic process to be followed and monitored for variations. 
B) allow the numbering of chromosomes and identification of variations. 
C) identify new somatic cells formed through mitosis and cytokinesis. 
D) distinguish the sex chromosome from the homologous chromosomes.

Question 18

A genetically normal male is always _____________ for genes on the X chromosome.

Accepted Answer

A) homozygous 
B) heterozygous 
C) hemizygous 
D) ambizygous 
A) homozygous 
B) heterozygous 
C) hemizygous 
D) ambizygous

Question 19

The key to accurate DNA replication is complementary base pairing.

Accepted Answer

A) True 
 B)False

Question 20

A boy, 9 years of age, is admitted to the pediatric ward with hemophilia A.He inherited this condition through a ___________ trait.

Accepted Answer

A) sex-linked dominant 
B) sex-influenced 
C) sex-linked 
D) sex-linked recessive 
A) sex-linked dominant 
B) sex-influenced 
C) sex-linked 
D) sex-linked recessive

Exam 4: Genes and Genetic Diseases

Which genetic disease has been linked to a mutation of the tumor-suppressor gene?

Chromosome abnormalities are the leading cause of mental retardation and miscarriage.

Match the genetic terms with the corresponding diseases. Terms may be used more than once. -Hemophilia

A person with XXXY has the genetic disorder called __________ syndrome.

Inserting bone marrow cells into an individual who produces abnormal erythrocytes is an example of _____ therapy.

Match the disease with its chromosomal abnormality. -An additional chromosome joining the normal homologous pair

Which of the following disorders has a mode of inheritance similar to hemophilia A?

RNA polymerase is the most important protein in DNA replication.

Match the disease with its chromosomal abnormality. -Single X chromosome with no homologous X or Y chromosome

In most cases of recessive disease, both parents of affected individuals are heterozygous carriers.

What is the diagnosis of a 13-year-old female who has a karyotype that reveals an absent homologous X chromosome with only a single X chromosome present with features that include a short stature, widely spaced nipples, reduced carrying angle at the elbow, and sparse body hair?

Match the genetic terms with the corresponding diseases. Terms may be used more than once. -Cystic fibrosis

DNA formation and protein synthesis occur in the cell nucleus.

Which is an important criterion for discerning autosomal recessive inheritance?

What is the second most commonly recognized genetic cause of mental retardation?

A couple has two children with a genetic disease.What is the probability that the next child will have the same genetic disease?

The purpose of a staining technique of chromosomes such as Giemsa is to:

A genetically normal male is always _____________ for genes on the X chromosome.

The key to accurate DNA replication is complementary base pairing.

A boy, 9 years of age, is admitted to the pediatric ward with hemophilia A.He inherited this condition through a ___________ trait.

Cellular Biology

Altered Cellular and Tissue Biology

The Cellular Environment: Fluids and Electrolytes, Acids and Bases

Genes, Environment, and Common Diseases

Innate Immunity: Inflammation

Adaptive Immunity

Alterations in Immunity and Inflammation

Infection

Stress and Disease

Biology, Clinical Manifestations, and Treatment of Cancer

Cancer Epidemiology

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function

Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Reproductive System

Alterations of the Reproductive Systems

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocyte Function

Alterations of Leukocyte, Lymphoid, and Hemostatic Function

Alterations of Hematologic Function in Children

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Alterations of Pulmonary Function in Children

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adult

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

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